Microbiology, Immunology & Pathology
Effective July 1, the ‘special appointment’ faculty positions of Drs. Anne Lenaerts and Dean Crick have been converted to ‘regular appointment’ tenure track positions. Congratulations to Anne and Dean for this well-deserved change in status. Oh and by the way, MIP still thinks you're both ‘special’, even though CSU doesn't anymore!
Sacré bleu! Congratulations to Dr. Christine Olver who has been awarded a Fulbright Scholarship. The Fulbright Program is the US government's flagship international exchange program designed to increase mutual understanding between the peoples of US and other countries. Fulbright Scholars are chosen for their academic merit and leadership potential. Christine and her savior-faire will be going to the Universite de Montpellier in Montpellier, France (which is situated in the southern part of the country on the Mediterranean Coast). We'll be saying au revoir to her for ~ 7 months on January 1, 2010.
"Every year in the United States, more than two thousand children are born with an intersex condition or disorder of sex development. What makes someone a boy or a girl? Is it external genitalia, chromosomes, DNA, environment, or some combination of these factors? Not even doctors or scientists are entirely clear. What is clear is that sex is not an either-or proposition: not girl/boy, XX/XY, switching between two poles like an on-off switch on a radio. Rather, sex is like the bass and treble knobs on that radio."
MIP's Gerry Callahan has just published through Chicago Review Press his latest book entitled Between XX and XY: Intersexuality and the Myth of Two Sexes The book provides an absorbing analysis of what makes people male or female and why those who do not fit into society's preconceived notions about sex often face a difficult path in life. Dr. Callahan also examines our obsession with sex and sexual intercourse through the ages.
Gerry Callahan will be at the Reader's Cove Bookstore on Thursday, July 23, 6:30pm for a book reading/signing.
"Lisa: Dad, don't you think you're overreacting?
Homer: Don't you think you're *under*reacting? "
Localized Immunosuppressive Environment in the Foreign Body Response to Implanted Biomaterials
David Higgins, Randy Basaraba, April Hohnbaum, Eric Lee, David Grainger and Mercedes Gonzalez-Juarrero
The American Journal of Pathology 175: 161-170
Among most medical specialists, including dentists, orthopaedic surgeons and ‘nip and tuck’ physicians, the implantation of medical devices is fairly common. With the development of stem cell tissue rebuilding technologies on the horizon, this trend is very likely to increase. A key factor related to the success of medical implants is how the body responds to it. Major problems to date include the encapsulation of the implant in fibrous deposits or degradation of the implant by a variety of secreted enzymes. Thus predicting/manipulating how a patient will react to an implant is of major medical importance. In their spare time when they aren't unraveling the intricacies of how the human immune system reacts to Mycobacterium tuberculosis, an MIP research team led by Mercedes Gonzalez-Juarrero has started a foray into this area of medical research which is commonly called the ‘Foreign Body Response’.
In this study, Dave Higgins, Mercedes and the rest of the gang implanted a 4 x5 mm nylon mesh into the back of C57BL/6 mice to establish an experimentally tractable in vivo system to observe the temporal and spatial patterns of cell migration, cytokine gene expression and encapsulation responses to this mesh over a 10 week period. Their data supported three major conclusions. First, they confirmed what has been observed in numerous in vitro and in vivo studies over the years thus supporting the validity of their mouse-mesh model system. Basically there was the expected initial inflammatory response to the nylon mesh after two weeks that subsided fairly quickly thereafter. In terms of a cellular response, there was a focal distribution of macrophages and granulocytes readily observed around the mesh by 4 weeks. About 30% of these macrophages fused to form multinucleated giant cells. The second major conclusion they made was that the Foreign Body Response is primarily a macrophage response. The macrophages that accumulate around the nylon mesh appear to be the key cells in terms of producing lysozyme and cytokines (particularly IL4, IL10, IL13 and TGF-B. Dendritic cells don't appear to be recruited and there was no data to support a role for the handful of lymphocytes in the area in cytokine production. The third and final major conclusion of the study is that the cytokines appear to be acting in combinations (rather than on their own) to contribute to aspects of the foreign body response. These data provide valuable in vivo confirmation for previous work done in tissue culture model systems and extend our understanding of immune cell-implant relationships. The next key steps in the study will likely be to assess how the mice react to a range of biomaterials and understand the potential contribution of the immunosuppressive cytokines (IL-10 and TGF-B) that are produced to opportunistic infections of implants.
We picked this study for our coveted ‘highlight of the month’ for three reasons. First, it establishes what may be a valuable new in vivo model system to study a very important aspect of human medicine. Second, it nicely shows the awesome power of MIP immunologists and pathologists when they get together in a collaborative effort to tackle a research question. Finally, it begs the question as to whether or not Mercedes’ future research direction will involve ‘TB or not TB’ ...
MIP Publications Late June - Early July 2009
MIP sends its collective condolences to Dwayne Hamar who lost his grandson in a tragic rodeo accident on June 28th
“We won't be dancing together on the high wire
Hanging from the trapeze
~from ‘the last carnival’
A Memorial Fund has been set up at the Yuma County Federal Credit Union
A big “Thank you” goes out to the hard working MIP Administrative Staff who have once again put in a bunch of hard days’ nights and closed the books for fiscal year end and are busy now getting the department ready for FY ‘10 (which began on July 1). Please take a moment out of your busy day this week, visit your facility office and thank the hardest working staff at the institution for their efforts in making MIP truly work.
The Bacteriologist Search Committee will be interviewing Dr. Tung Hoang on August 10 & 11. Interview details will be sent to the department listservs as they develop.
The IDSC-IDRC Director Search Committee will be interviewing;
If you've recently walked through the Pathology Building you probably noticed a lack of Veterinary Pathologists. With the opening of the new Diagnostic Medicine Center many MIP Faculty and the Veterinary Residents have been migrating to their new posh diggs located just north of the Veterinary Teaching Hospital. Some MIP Faculty have moved from the VTH, some from the old D-Lab, and some from the Pathology Building. Take our DMC Virtual Tour and check the listing below to find where you might now locate your favorite Diagnostic Faculty and Students:
316 - Tawfik Aboellail
The 6th Annual Biosafety and Biosecurity Training Course, directed by our own Dr. Bob Ellis (CSU Director of Biosafety) was held July 8-15, 2009 at the Hilton Hotel, Fort Collins. Topics included biosafety and biosecurity in veterinary clinics, animal/plant research and diagnostics. Please visit the course website for more information.
This year's meeting of the Rocky Mountain Virology Club will be held at Pingree Park on Oct 2-4 (Friday evening to Sunday noon).
The Wilusz Lab was featured in Radiation Contol Office's quarterly publication of ‘E-News’ in an article entitled, "What's Hot in the Wilusz Lab". Read the publication.
“If you enter this world knowing you are loved and you leave this world knowing the same, then everything that happens in between can be dealt with. ”
~ Michael Joseph Jackson 1958-2009
Ever notice that a good sized chunk of the name plate that hangs over Dr. Roxann Karkhoff-Schweizer's office has been blacked out?
A little speculation on why the black patch is up there..
Wouldn't this Coveted
Looking for something to spice up your Monday nights? Why not consider getting a team together to compete in the CSU Bowling league at Chipper's Lanes. It's a handicapped league so you can bowl Obama-esque and still be competitive and have a great time. The MIP Dept already has one team in the league - so a little inter-lab, inter-office, or inter-MIP facility competition could be fun.
75 members of the extended MIP family will be watching from behind first base as the red hot Colorado Rockies take on the Chicago Cubs on Saturday, August 8th at 6:10PM at Coors Field in Denver. If you'll be attending the game, a few helpful hints:
New Grant Awards
John Belisle, "RP-018 Vascular Stabilization as a Broad Therapeutic Platform for Biodefense", HHS-NIH-NIAID
Dean Crick, "Global Alliance for TB Drug Development", Global Alliance for TB Drug Development
Lars Eisen, "ARRA Vector Surveillance Ontology and Vector Management Ontology", HHS-NIH-NIAID
Anne Lenaerts, "Evaluation of Experimental Compounds in a Macrophage Model for M. tuberculosis", Vertex Pharmaceuticals Incorporated
Jeffrey Wilusz, "Mechanism of Regulation fo mRNA Stability", HHS-NIH-National Inst of General Medical Science
Mark Zabel, "Evaluation of Biological and Environmental Materials for Chronic Wasting Disease Prions using Protein Misfoldi....", USDA-APHIS
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