Microbiology, Immunology & Pathology
MIP Graduate Students that will participate in the May 15th Ph.D. Graduation Ceremony...
MIP Graduate Students that will participate in the May 15th M.S. Graduation Ceremony...
MIP Undergraduates that will participate in the May 15th B.S. Graduation Ceremony...
Congratulations to Robert Jones on his election to Faculty Council as the MIP Department Representative for a three year term starting July 1.
Congratulations to Mark Zabel on his appointment as a CVMBS Representative on the Faculty Council Standing Committee on Scholarship, Research And Graduate Education for a three year term starting July 1.
As always, a big thanks to all of these MIPers who make valuable contributions to the shared governance of our institution.
Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay
Nicholas Haley, Davis Seelig, Mark Zabel, Glenn Telling and Ed Hoover
Chronic Wasting Disease (CWD), a neurological disease caused by infectious proteins called prions, is very prevalent in Colorado cervids. That means that up to 30% of deer and elk can be affected by the disease in our neck of the woods (and that Walden CO might also be called the CWD-affected moose viewing capital). The high incidence of the disease implies that it is readily transmitted between animals - but precisely how this transmission occurs is unclear. In a high profile Science paper in 2006, the Hoover lab and collaborators showed by oral inoculation in deer that saliva and blood of affected animals contained infectious CWD prions. To date, however, there has been no evidence for CWD prions in the major animal byproducts, namely urine or feces. That's where this study comes in.
Nick, Davis, Mark and Ed dove head first into this excrement (figuratively speaking of course) to search for evidence for CWD prions. Instead of the more cumbersome oral inoculation in deer assay that was used in the 2006 study, they used direct intracerebral inoculations into transgenic mice that were specifically engineered to contain the cervid precursor protein (called PrP) so that they would be susceptible to the disease. The idea was that this assay may very well be faster and more sensitive. Concentrated urine and saliva samples were inoculated and one year (yes a full 13 full moons) later, the animals were checked for disease. Not surprisingly based on previous results, none of the control came down with disease and 8/9 saliva-inoculated animals showed clear evidence of CWD. What makes this study very significant is that when the urine samples were tested, ~ one third of the animals were positive for CWD - the first evidence ever reported for CWD prions in the urine of white tailed deer.
So why did we choose this manuscript to highlight this month. First and foremost, it obviously adds a very important clue to unraveling the puzzle of CWD transmissibility by finding evidence for prions in deer urine. Second, the study establishes the value of the mouse bioassay as well as a test tube-based amplification technique for detecting what are likely low concentrations of CWD prions in biological samples. This increase in assay speed and sensitivity should prove very useful in future studies. Finally, the article uses one of our favorite words, 'portend', in the abstract - which is clearly a harbinger of more good things to come..
MIP Publications Late March - Early April 2009
The following MIP employees are being recognized for their dedicated service to CSU as follows:
40 Years of Service
35 Years of Service
25 Years of Service
20 Years of Service
15 Years Of Service
10 Years Of Service
Graduation Ceremony Information
Fall Semester MIP Topics (MIP700)
Title: Biological Alchemy: Induced Pluripotent Stem Cells
Instructor: Jeff Wilusz
The Fall 2009 iteration of our MIP700 Topics course will be at the cutting-edge of cell biology (and [given the interests of the instructor] surprisingly will have nothing to do with RNA biology!). Using a very simple cocktail of four transcription factors, dramatic advances have recently been made in cellular reprogramming. In this form of cell biology ‘alchemy’, fully differentiated mature cells can be de-differentiated back into stem cells – which can then (in theory anyway) be differentiated into any cell type you desire. This groundbreaking technology (Science magazine named it as the ‘Breakthrough of the Year’ for 2008) has the potential to develop new tools to study disease, create designer cell lines to treat/cure diseases using a patient’s own cells, provide dramatic new insights into the processes underlying cellular development and fate determination, etc., etc. etc.
In February, Pathology Veterinary Residents had dinner with Veterinary Students of the Pathology Club. The students were able to discuss their interests, how to get into a residency program and what it was like being a resident at CSU. It was well attended by both the residents and the vet student club members and a lot of valuable information was shared.
See the Photo Gallery from the dinner.
MIP Takes You Out to the Ballgame
MIP has reserved a block of tickets in section 117 to see the Colorado Rockies take on the Chicago Cubs on Saturday, August 8th at 6:10PM at Coors Field in Denver. The price per ticket is $40 – a $10 savings over the face value. All members of the MIP family are invited - so bring the spouse, bring the kiddies, etc. Tickets are going fast - so please email Jeff Wilusz ASAP if you'd like to reserve some tickets to this ‘can't-be-missed’ Departmental outing.
“Comedy is like a frog – you can dissect it, you learn how it works, but it will die in the process.”
Dr. Gary Mason helps to put some of the finishing touches on the new Diagnostic Medical Center Building
Monfort Professor, RCE Director, and Rockies Relief Pitcher?
Who will serve as a role model for our profession’s youth?
Where have all the heroes gone?
Look no further
We proudly present to you Episode 4 of "Captain Justice."
New Grant Awards Awards
Mary Jackson, "PimA Assay Development and Preparation of Biological Reagents", European Union
Ric Slayden, "FtsZ Inhibitors for Anti-TB Chemotherapy Novel Antimicrobials Targeting Cell Division", State Univer. of New York at Stonybrook
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|MIP Newsletter Volume 6, Issue 4, April 2009||MIP Home CVMBS Home CSU Home|