Scott Earley, PhD
I have extensive research experience in cardiovascular physiology and I maintain a strong interest in regulation of vasomotor activity by ion channels expressed by arterial smooth muscle cells. I'm also interested in how factors produced by the vascular endothelium influence blood vessel function. I use a number of experimental approaches for these studies, including patch clamp and intracellular electrophysiology, molecular biology, antisense-mediated suppression of ion channel expression in intact arteries, high-speed laser scanning confocal imaging of dynamic intracellular Ca2+ events, and video microscopy recordings of changes diameter and smooth muscle cell Ca2+ in pressurized resistance arteries. My research focuses on the role of transient receptor potential (TRP) channels expressed by cerebral artery smooth muscle in vascular function. TRP channels are a ubiquitously expressed superfamily of cation channels that are important in sensory transduction, osmotic regulation, and other physiological and pathophysiological responses.
Reading SA, Earley S, Waldron BJ, Welsh DG, Brayden JE. 2004. TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral artery. Am J Physiol Heart Circ Physiol [Epub ahead of print].
Naik JS, Earley S, Resta TC, Walker BR. 2005. Pressure-induced smooth muscle cell depolarization in pulmonary arteris from control and chronically hypoxic rats does not cause myogenic vasoconstriction. J Appl Physiol 98:1119-1124.
Earley S, Waldron BJ, Brayden JE. 2004. Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ Res 95:922-929.