Publications

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2012 Publications
RESEARCH
Moon SL, Barnhart MD, Wilusz J. Inhibition and avoidance of mRNA degradation by RNA viruses. Curr Opin Microbiol. 2012;15:500-5. doi:10.1016/j.mib.2012.04.009. PubMed PMID: 22626865; PubMed Central PMCID: PMC3424362.
PREVIEW Wilusz CJ, Wilusz J. HuR and Translation-The Missing Linc(RNA). Mol Cell. 2012,  47(4):495-6. PubMed PMID: 22920290
RESEARCH Dickson AM, Anderson JR, Barnhart MD, Sokoloski KJ, Oko L, Opyrchal M, Galanis E, Wilusz CJ, Morrison TE, Wilusz J. Dephosphorylation of HuR Protein During Alphavirus Infection Is Associated with HuR Relocalization to the Cytoplasm. J Biol Chem. 2012 Aug 22. [Epub ahead of print] PubMed PMID: 22915590
RESEARCH Lee JE, Lee JY, Trembly J, Wilusz J, Tian B, Wilusz CJ. The PARN Deadenylase Targets a Discrete Set of mRNAs for Decay and Regulates Cell Motility in Mouse Myoblasts. PLoS Genet. 2012  8(8):e1002901. PubMed PMID: 22956911; PubMed Central PMCID: PMC3431312
RESEARCH Moon SL, Anderson JR, Kumagai Y, Wilusz CJ, Akira S, Khromykh AA, Wilusz J. A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability. RNA. 2012 Sep 24. [Epub ahead of print] PubMed PMID: 23006624
METHOD Moon SL, Wilusz J. In Vitro Transcription of Modified RNAs. Methods Mol Biol. 2012;941:171-80. doi: 10.1007/978-1-62703-113-4_13. PubMed PMID: 23065561
RESEARCH Palusa S, Ndaluka C, Bowen RA, Wilusz CJ, Wilusz J. The 3' Untranslated Region of the Rabies Virus Glycoprotein mRNA Specifically Interacts with Cellular PCBP2 Protein and Promotes Transcript Stability. PLoS One. 2012;7(3):e33561. Epub 2012 Mar 16. PubMed PMID: 22438951; PubMed Central PMCID: PMC3306424.
RESEARCH Neff, AT,Lee, JY, Wilusz, J, Tian, B, Wilusz CJ. Global analysis reveals multiple pathways for unique regulation of mRNA decay in induced pluripotent stem cells. Genome Res. 22(8):1457-67.
2011 Publications
RESEARCH Sagawa F, Ibrahim H, Morrison AL, Wilusz CJ, Wilusz J. Nucleophosmin deposition during mRNA 3' end processing influences poly(A) tail length. EMBO J. 2011 30(19):3994-4005. doi: 10.1038/emboj.2011.272. PubMed PMID: 21822216.
RESEARCH Dickson AM, Wilusz J. Strategies for viral RNA stability: live long and prosper. Trends Genet. 2011 27(7):286-93. PubMed PMID: 21640425; PubMed Central PMCID: PMC3123725.
RESEARCH Bellofatto V, Wilusz J. Transcription and mRNA stability: parental guidance suggested. Cell. 2011 Dec 23;147(7):1438-9. PubMed PMID: 22196721.
2010 Publications
PREVIEW Wilusz CJ, Wilusz J. Consequences of mRNA wardrobe malfunctions. Cell. 2010 Dec 10;143(6):863-5. PubMed PMID: 21145451.
RESEARCH Brackney DE, Scott JC, Sagawa F, Woodward JE, Miller NA, Schilkey FD, Mudge J, Wilusz J, Olson KE, Blair CD, Ebel GD. C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS Negl Trop Dis. 2010 4(10):e856. PubMed PMID: 21049065; PubMed Central PMCID: PMC2964293.
EDITORIAL Wilusz J. RNA in the classroom: beyond the "RN-ABCs". Wiley Interdiscip Rev RNA. 2010 1(2):201. doi: 10.1002/wrna.38. PubMed PMID: 21935884.
RESEARCH Sokoloski KJ, Dickson AM, Chaskey EL, Garneau NL, Wilusz CJ, Wilusz J. (2010) Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells. Cell Host Microbe 8:196-207. PMID: 20709296.
RESEARCHLee JE, Lee JY, Wilusz J, Tian B, Wilusz CJ. (2010) Systematic analysis of cis-elements in unstable mRNAs demonstrates that CUGBP1 is a key regulator of mRNA decay in muscle cells. PLoS One 5:e11201. PMID: 20574513
REVIEWDickson, AM, Wilusz CJ. (2010) Repeat expansion diseases: When a good RNA turns bad.  WIREs RNA 1:173-192
PREVIEWLee JE, Wilusz J. (2010) Translational symphony in (hnRNP) C major for APP. Nat Struct Mol Biol. 17:675-6. PMID: 20520660
PREVIEWDickson AM, Wilusz J. (2010) Polyadenylation: alternative lifestyles of the A-rich (and famous?). EMBO J. 29:1473-4.  PMID: 20442727;
PREVIEWWilusz CJ, Wilusz J. (2010) trans Regulation: do mRNAs have a herd mentality? Dev Cell. 18:333-4  PMID: 20230739.
2009 Publications
REVIEWSokoloski KJ, Chaskey EL, Wilusz J. (2009) Virus-mediated mRNA decay by hyperadenylation. Genome Biol. 10:234. PMID: 19678916
METHOD

Garneau NL, Wilusz CJ, Wilusz J. (2008) Chapter 5. In vivo analysis of the decay of transcripts generated by cytoplasmic RNA viruses. Methods Enzymol. 449:97-123. PMID: 19215755
METHODSokoloski KJ, Wilusz J, Wilusz CJ. (2008) The preparation and applications of cytoplasmic extracts from mammalian cells for studying aspects of mRNA decay. Methods Enzymol.448:139-63. PMID: 19111175
RESEARCHSánchez-Vargas I, Scott JC, Poole-Smith BK, Franz AW, Barbosa-Solomieu V, Wilusz J, Olson KE, Blair CD. (2009) Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway. PLoS Pathog. 5:e1000299. PMID: 19214215
PREVIEWWilusz J. (2009) RNA stability: is it the endo' the world as we know it? Nat Struct

Mol Biol. 16:9-10. PMID: 19125167
2008 Publications
RESEARCHZhang L, Lee JE, Wilusz J, Wilusz CJ. (2008) The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy. J Biol Chem. 283:22457-63. PMID: 18559347
RESEARCHKhaladkar M, Patel V, Bellofatto V, Wilusz J, Wang JT. (2008) Detecting conserved secondary structures in RNA molecules using constrained structural alignment. Comput Biol Chem. 32:264-72. PMID: 18472302
METHODSokoloski K, Anderson JR, Wilusz J. (2008) Development of an in vitro mRNA decay system in insect cells. Methods Mol Biol.419:277-88. PMID: 18369990
RESEARCHCampbell CL, Keene KM, Brackney DE, Olson KE, Blair CD, Wilusz J, Foy BD.(2008)  Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC Microbiol. 8:47. PMID: 18366655
PREVIEWWilusz CJ, Wilusz J. (2008) New ways to meet your (3') end oligouridylation as a step on the path to destruction. Genes Dev. 22:1-7 PMID: 18172159
REVIEWIbrahim H, Wilusz J, Wilusz CJ. (2008) RNA recognition by 3'-to-5' exonucleases: the substrate perspective. Biochim Biophys Acta.1779:256-65. PMID: 18078842
RESEARCHGarneau NL, Sokoloski KJ, Opyrchal M, Neff CP, Wilusz CJ, Wilusz J. (2008) The 3' untranslated region of Sindbis virus represses deadenylation of viral transcripts in mosquito and mammalian cells. J Virol. 82:880-92. PMID: 17977976
2007 Publications
RESEARCH Bergman N, Moraes KC, Anderson JR, Zaric B, Kambach C, Schneider RJ, Wilusz CJ, Wilusz J. (2007) Lsm proteins bind and stabilize RNAs containing 5' poly(A) tracts. Nat Struct Mol Biol. 14(9):824-831 
RESEARCH Kurt TD, Perrott MR, Wilusz CJ, Wilusz J, Supattapone S, Telling GC, Zabel MD, Hoover EA. (2007) Efficient in vitro amplification of chronic wasting disease PrPRES. J Virol. 81(17):9605-8 
REVIEW Garneau NL, Wilusz J, Wilusz CJ. (2007) The highways and byways of mRNA decay. Nat Rev Mol Cell Biol. 8(2):113-26 
REVIEW Wilusz CJ, Wilusz J. (2007) HuR-SIRT: the hairy world of posttranscriptional control. Mol Cell. 25(4):485-7. 
2006 Publications
REVIEW Sokoloski KJ, Wilusz CJ, Wilusz J. (2006) Viruses: overturning RNA turnover. RNA Biol. 3(4):140-4. 
RESEARCH Anderson JR, Mukherjee D, Muthukumaraswamy K, Moraes KC, Wilusz CJ, Wilusz J. (2006) Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. RNA. 12(10):1810-6.
RESEARCH Moraes K, Wilusz CJ, Wilusz J. (2006) CUG-BP binds to RNA substrates and recruits PARN deadenylase. RNA 12:1084-1091
RESEARCH Palaniswamy V, Moraes K, Wilusz CJ, Wilusz J. (2006) Nucleophosmin is selectively deposited on mRNA during polyadenylation. Nat. Struct. Mol. Biol. 13:429-435
2005 Publications
RESEARCH Hu J, Lutz CS, Wilusz J, Tian B. (2005) Bioinformatic identification of candidate cis-regulatory elements involved in human mRNA polyadenylation.
RNA. 11:1485-93.
REVIEW Wilusz CJ, Wilusz J (2005) Eukaryotic Lsm Proteins: lessons from bacteria. Nat. Struct. Mol. Biol. 12:1031-1036
RESEARCH
Opyrchal, M., Anderson, J.T., Sokoloski, K.J., Wilusz, C.J. and Wilusz, J. (2005) A cell-free mRNA stability assay reveals conservation of the enzymes and mechanisms of mRNA decay between mosquito and mammalian cell lines. Insect Biochemistry & Molecular Biology 35(12):1321-34
RESEARCH Sachchithananthan M, Stasinopoulos SJ, Wilusz J, Medcalf RL. (2005) The relationship between the prothrombin upstream sequence element and the G20210A polymorphism: the influence of a competitive environment for mRNA 3'-end formation.
Nucleic Acids Res 33(3):1010-20.
RESEARCH Seal R, Temperley R, Wilusz J, Lightowlers RN, Chrzanowska-Lightowlers ZM. (2005) Serum-deprivation stimulates cap-binding by PARN at the expense of eIF4E, consistent with the observed decrease in mRNA stability. Nucleic Acids Res 33(1):376-87.
2004 Publications
REVIEW Fritz DT, Bergman N, Kilpatrick WJ, Wilusz CJ, Wilusz J. (2004) Messenger RNA decay in Mammalian cells: the exonuclease perspective. Cell Biochem Biophys 41(2):265-78.
REVIEW Wilusz CJ, Wilusz J. (2004) Bringing the role of mRNA decay in the control of gene expression into focus. Trends Genet 20(10):491-7.
RESEARCH Milone J, Wilusz J, Bellofatto V. (2004) Characterization of deadenylation in trypanosome extracts and its inhibition by poly(A)-binding protein Pab1p. RNA 10(3):448-57.
RESEARCH Mukherjee D, Fritz DT, Kilpatrick WJ, Gao M, Wilusz J. (2004) Analysis of RNA exonucleolytic activities in cellular extracts. Methods Mol Biol 257:193-212.
RESEARCH Bergman N, Milone J, Bates EJ, Opyrchal M, Bellofatto V, Wilusz J. (2004) Assessing messenger RNA decapping in cellular extracts. Methods Mol Biol 257:181-92.
Publications from work completed prior to joining Colorado State University in 2003
RESEARCHDuttagupta R, Tian B, Wilusz CJ, Khounh DT, Soteropoulos P, Ouyang M, Dougherty JP, Peltz SW. (2005) Global analysis of Pub1p targets reveals a coordinate control of gene expression through modulation of binding and stability. Mol Cell Biol. 25:5499-513. PMID: 15964806
RESEARCHDuttagupta R, Vasudevan S, Wilusz CJ, Peltz SW. (2003) A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated region. Mol Cell Biol. 23:2623-32. PMID:12665566
RESEARCH Kash JC, Cunningham DM, Smit MW, Park Y, Fritz DT, Wilusz J, Katze MG. (2002) Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis. J Virol. 76(20):10417-26.
RESEARCH Milone J, Wilusz J, Bellofatto V. (2002) Identification of mRNA decapping activities and an ARE-regulated 3' to 5' exonuclease activity in trypanosome extracts. Nucleic Acids Res. 30(18):4040-50.
RESEARCH Natalizio BJ, Muniz LC, Arhin GK, Wilusz J, Lutz CS. (2002) Upstream elements present in the 3'-untranslated region of collagen genes influence the processing efficiency of overlapping polyadenylation signals. J Biol Chem. 277(45):42733-40. Epub 2002 Aug 27.
METHOD/RESEARCH Bergman N, Opyrchal M, Bates EJ, Wilusz J. (2002) Analysis of the products of mRNA decapping and 3'-to-5' decay by denaturing gel electrophoresis. RNA.;8(7):959-65.
RESEARCH Arhin GK, Boots M, Bagga PS, Milcarek C, Wilusz J. (2002) Downstream sequence elements with different affinities for the hnRNP H/H' protein influence the processing efficiency of mammalian polyadenylation signals. Nucleic Acids Res. 30(8):1842-50.
RESEARCH Mukherjee D, Gao M, O'Connor JP, Raijmakers R, Pruijn G, Lutz CS, Wilusz J. (2002) The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J. 21(1-2):165-74.
LETTER Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donze O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M Jr, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N,Tahara SM, Thomas AA, Toulme JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. (2001) New ways of initiating translation in eukaryotes. Mol Cell Biol. 21(23):8238-46.
RESEARCH Wilusz CJ, Gao M, Jones CL, Wilusz J, Peltz SW. (2001) Poly(A)-binding proteins regulate both mRNA deadenylation and decapping in yeast cytoplasmic extracts. RNA.7(10):1416-24.
RESEARCH Veraldi KL, Arhin GK, Martincic K, Chung-Ganster LH, Wilusz J, Milcarek C. (2001) hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells. Mol Cell Biol. 21(4):1228-38.
RESEARCH Evans D, Perez I, MacMorris M, Leake D, Wilusz CJ, Blumenthal T. (2001) A complex containing CstF-64 and the SL2 snRNP connects mRNA 3' end formation and trans-splicing in C. elegans operons. Genes Dev. 15(19):2562-71.
RESEARCH Gao M, Fritz DT, Ford LP, Wilusz J. (2000) Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro. Mol Cell.
5(3):479-88.
METHOD/REVIEW Fritz DT, Ford LP, Wilusz J. (2000) An in vitro assay to study regulated mRNA stability.
Sci STKE. 2000(61):PL1.
METHOD/RESEARCH Bagga PS, Wilusz J. (1999) Northwestern screening of expression libraries. Methods Mol Biol. 118:245-56.
RESEARCH Park YW, Wilusz J, Katze MG. (1999) Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1. Proc Natl Acad Sci U S A. 96(12):6694-9.
METHOD Ford LP, Wilusz J. (1999) An in vitro system using HeLa cytoplasmic extracts that reproduces regulated mRNA stability. Methods. 17(1):21-7.
RESEARCH Ford LP, Wilusz J. (1999) 3'-Terminal RNA structures and poly(U) tracts inhibit initiation by a 3'-->5' exonuclease in vitro. Nucleic Acids Res. 27(4):1159-67.
RESEARCH Ford LP, Watson J, Keene JD, Wilusz J. (1999) ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev. 13(2):188-201.
RESEARCH Bagga PS, Arhin GK, Wilusz J. (1998) DSEF-1 is a member of the hnRNP H family of RNA-binding proteins and stimulates pre-mRNA cleavage and polyadenylation in vitro. Nucleic Acids Res. 26(23):5343-50.
RESEARCH Chen F, Wilusz J. (1998) Auxiliary downstream elements are required for efficient polyadenylation of mammalian pre-mRNAs. Nucleic Acids Res. 26(12):2891-8.
RESEARCH Ford LP, Bagga PS, Wilusz J. (1997) The poly(A) tail inhibits the assembly of a 3'-to-5' exonuclease in an in vitro RNA stability system. Mol Cell Biol. 17(1):398-406.
RESEARCH Banga SS, Ozer HL, Wilusz J. (1996) Assignment of GRSF1 encoding a poly(A)+ mRNA binding protein to human chromosome 4q13. Cytogenet Cell Genet. (4):295-6.
RESEARCH Chen F, MacDonald CC, Wilusz J. (1995) Cleavage site determinants in the mammalian polyadenylation signal. Nucleic Acids Res. 23(14):2614-20
RESEARCH Bagga PS, Ford LP, Chen F, Wilusz J. (1995) The G-rich auxiliary downstream element has distinct sequence and position requirements and mediates efficient 3' end pre-mRNA processing through a trans-acting factor. Nucleic Acids Res. 23(9):1625-31.
RESEARCH Hubbard K, Dhanaraj SN, Sethi KA, Rhodes J, Wilusz J, Small MB, Ozer HL. (1995) Alteration of DNA and RNA binding activity of human telomere binding proteins occurs during cellular senescence. Exp Cell Res. 218(1):241-7.
RESEARCH MacDonald CC, Wilusz J, Shenk T. (1994) The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location. Mol Cell Biol. 14(10):6647-54.
RESEARCH Chou ZF, Chen F, Wilusz J. (1994) Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals. Nucleic Acids Res. 22(13):2525-31.
RESEARCH Qian Z, Wilusz J. (1994) GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element. Nucleic Acids Res. 22(12):2334-43.
RESEARCH Qian Z, Wilusz J. (1993) Cloning of a cDNA encoding an RNA binding protein by screening expression libraries using a northwestern strategy. Anal Biochem. 212(2):547-54.
RESEARCH Qian ZW, Wilusz J. (1991) An RNA-binding protein specifically interacts with a functionally important domain of the downstream element of the simian virus 40 late polyadenylation signal. Mol Cell Biol. 11(10):5312-20.
RESEARCH Takagaki Y, Manley JL, MacDonald CC, Wilusz J, Shenk T. (1990) A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs. Genes Dev.
4(12A):2112-20.
RESEARCH Wilusz J, Shenk T. (1990) A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal. Mol Cell Biol. 10(12):6397-407.
RESEARCH Wilusz J, Shenk T, Takagaki Y, Manley JL. (1990) A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates. Mol Cell Biol. 10(3):1244-8.
RESEARCH Wilusz J, Pettine SM, Shenk T. (1989) Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signal. Nucleic Acids Res. 17(10):3899-908.
RESEARCH Wilusz J, Feig DI, Shenk T. (1988) The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites. Mol Cell Biol. 8(10):4477-83.
RESEARCH Wilusz J, Shenk T. (1988) A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif. Cell. 52(2):221-8.
RESEARCH Wilusz J, Keene JD. (1986) Autoantibodies specific for U1 RNA and initiator methionine tRNA. J Biol Chem. 261(12):5467-72.
RESEARCH Kiley MP, Wilusz J, McCormick JB, Keene JD. (1986) Conservation of the 3' terminal nucleotide sequences of Ebola and Marburg virus. Virology. 149(2):251-4.
RESEARCH Wilusz J, Youngner JS, Keene JD. (1985) Base mutations in the terminal noncoding regions of the genome of vesicular stomatitis virus isolated from persistent infections of L cells. Virology. 140(2):249-56.
RESEARCH Wilusz J, Keene JD. (1984) Interactions of plus and minus strand leader RNAs of the New Jersey serotype of vesicular stomatitis virus with the cellular La protein. Virology.
135(1):65-73.