Room: B325 Microbiology
I am interested in mechanisms of viral evasion from eukaryotic host RNA decay machinery, a potential host mechanism for the removal of non-self (viral) RNA. Viruses of the family Flaviviridae have co-evolved with host eukaryotic cells, and create some interesting RNA species that may prove to interact with host RNA decay machinery to the benefit of the virus.
I am also interested in looking at RNA decay as a mechanism for the control of short-lived, potent immunomodulators in cells that communicate with and react to leukocytes during wound healing or infection. Aberrations in RNA decay or sequestration of gene products crucial for normal wound repair processes may prove to play a major role in pathogenesis of autoimmune disease and other chronic diseases with mysterious etiologies.