Nicole Garneau

Graduate Student

Phone: 970-491-4881
Fax: 970-491-4941
Email: nicole.garneau@colostate.edu

Degrees

• B.A.- Genetics and Microbiology- Rutgers College, New Brunswick NJ

Research Interests

The genomic RNAs of viruses, such as Sindbis virus (SINV), a single-stranded positive sense prototypic Alphavirus, have many of the same features as cellular mRNA, including the presence of a 5' cap structure and a 3' poly(A) tail. This in part explains how RNA viruses have adapted to take advantage of a number of cellular factors and processes to gain entry into cells and to maximize their gene expression and replication. My goal is to better understand the interaction between the viral RNA and the mRNA decay machinery by examining the mechanism of stabilization and decay of Sindbis virus RNAs.

Publications

Garneau N.L., Wilusz J, Wilusz C.J. (2007). The highways and byways of mRNA decay. Nat Rev Mol Cell Biol. 2:113-26.

Vasudevan S, Garneau N, Tu Khounh D, and Peltz S.W. (2005) p38 Mitogen-Activated Protein Kinase/Hog1p Regulates Trnslation of the AU-Rich-Element-Bearing MFA2 Transcript. Molecular and Cellular Biology. (22):9753-63.