Alexa Dickson, PhD
Post Doctoral Fellow
Room: B429 Microbiology
Alexa is interested in understanding how changes in mRNA stability may contribute to pathogenesis in myotonic dystrophy. She is also working to discover how the HuR RNA binding protein is induced to relocalize during alphavirus infections.
Alexa's research is funded by the Myotonic Dystrophy Foundation
Sokoloski KJ, Dickson AM, Chaskey EL, Garneau NL, Wilusz CJ, Wilusz J. (2010) Sindbis virus usurps the cellular HuR protein to stabilize its transcripts and promote productive infections in mammalian and mosquito cells. Cell Host Microbe 8:196-207. PMID: 20709296
Dickson, AM, Wilusz CJ. (2010) Repeat expansion diseases: When a good RNA turns bad. WIREs RNA 1:173-192
Dickson AM, Wilusz J. (2010) Polyadenylation: alternative lifestyles of the A-rich (and famous?). EMBO J. 29:1473-4. PMID: 20442727
Dickson A, Osman E, Lorson CL. A negatively acting bifunctional RNA increases survival motor neuron both in vitro and in vivo. Hum Gene Ther. 2008 Nov;19(11):1307-15. PubMed PMID: 19848583.
Baughan TD, Dickson A, Osman EY, Lorson CL. Delivery of bifunctional RNAs that target an intronic repressor and increase SMN levels in an animal model of spinal muscular atrophy. Hum Mol Genet. 2009 May 1;18(9):1600-11. Epub 2009 Feb 19. PubMed PMID: 19228773; PubMed Central PMCID: PMC2667287.
Lorson MA, Dickson AM, Shaw DJ, Todd AG, Young EC, Morse R, Wolstencroft C, Lorson CL, Young PJ. Identification and characterisation of a nuclear localisation signal in the SMN associated protein, Gemin4. Biochem Biophys Res Commun. 2008 Oct 10;375(1):33-7. Epub 2008 Jul 31. PubMed PMID: 18675250.
Baughan T, Shababi M, Coady TH, Dickson AM, Tullis GE, Lorson CL. Stimulating full-length SMN2 expression by delivering bifunctional RNAs via a viral vector. Mol Ther. 2006 Jul;14(1):54-62. Epub 2006 Mar 31. PubMed PMID: 16580882.