Alan Godwin

Alan Godwin

Research Scientist

Room: B325 Microbiology
Phone: 970-491-4881
Fax:970-491-1815
Email:

Degrees

  • B.A., Chemistry & Biology, Pomona College, Claremont, CA
  • Ph.D., Genetics, Yale University, New Haven, CT

Research Interests

Alan has worked extensively on the mosquito RNA decay project and mentored many undergraduate students. He is now working on the nucleophosmin project to understand how nucleophosmin interacts with the 3 end formation machinery to regulate poly(A) tail length.

Recent Publications

In vivo Electroporation of Morpholinos into the Regenerating Adult Zebrafish Tail Fin. Hyde DR, Godwin AR, Thummel R. J Vis Exp. 2012 Mar 29;(61). pii: 3632. doi: 10.3791/3632.

The nude mutant gene Foxn1 is a HOXC13 regulatory target during hair follicle and nail differentiation. Potter CS, Pruett ND, Kern MJ, Baybo MA, Godwin AR, Potter KA, Peterson RL, Sundberg JP, Awgulewitsch A. J Invest Dermatol. 2011 Apr;131(4):828-37. Epub 2010 Dec 30.

Thummel R, Ju M, Sarras MP Jr, Godwin AR. Both Hoxc13 orthologs are functionally important for zebrafish tail fin regeneration. Dev Genes Evol. 2007 Jun;217(6):413-20. Epub 2007 Apr 17. PubMed PMID: 17437127.

Alam SM, Konno T, Dai G, Lu L, Wang D, Dunmore JH, Godwin AR, Soares MJ. A uterine decidual cell cytokine ensures pregnancy-dependent adaptations to a physiological stressor. Development. 2007 Jan;134(2):407-15. Epub 2006 Dec 13. PubMed PMID: 17166917.

Thummel R, Bai S, Sarras MP Jr, Song P, McDermott J, Brewer J, Perry M, Zhang X, Hyde DR, Godwin AR. Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Dev Dyn. 2006 Feb;235(2):336-46. PubMed PMID: 16273523.

Thummel R, Burket CT, Brewer JL, Sarras MP Jr, Li L, Perry M, McDermott JP, Sauer B, Hyde DR, Godwin AR. Cre-mediated site-specific recombination in zebrafish embryos. Dev Dyn. 2005 Aug;233(4):1366-77. PubMed PMID: 15977183.

Bai S, Thummel R, Godwin AR, Nagase H, Itoh Y, Li L, Evans R, McDermott J, Seiki M, Sarras MP Jr. Matrix metalloproteinase expression and function during fin regeneration in zebrafish: analysis of MT1-MMP, MMP2 and TIMP2. Matrix Biol. 2005 Jun;24(4):247-60. PubMed PMID: 15935631.

Steenhard BM, Isom KS, Cazcarro P, Dunmore JH, Godwin AR, St John PL, Abrahamson DR. Integration of embryonic stem cells in metanephric kidney organ culture. J Am Soc Nephrol. 2005 Jun;16(6):1623-31. Epub 2005 May 4. PubMed PMID: 15872079.

Ain R, Dai G, Dunmore JH, Godwin AR, Soares MJ. A prolactin family paralog regulates reproductive adaptations to a physiological stressor. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16543-8. Epub 2004 Nov 15. PubMed PMID: 15545614; PubMed Central PMCID: PMC534510.

Thummel R, Li L, Tanase C, Sarras MP Jr, Godwin AR. Differences in expression pattern and function between zebrafish hoxc13 orthologs: recruitment of Hoxc13b into an early embryonic role. Dev Biol. 2004 Oct 15;274(2):318-33. PubMed PMID: 15385162.

Godwin AR, Capecchi MR. Hair defects in Hoxc13 mutant mice. J Investig Dermatol Symp Proc. 1999 Dec;4(3):244-7. Review. PubMed PMID: 10674376.

Godwin AR, Stadler HS, Nakamura K, Capecchi MR. Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13042-7. PubMed PMID: 9789037; PubMed Central PMCID: PMC23702.

Godwin AR, Capecchi MR. Hoxc13 mutant mice lack external hair. Genes Dev. 1998 Jan 1;12(1):11-20. PubMed PMID: 9420327; PubMed Central PMCID: PMC316401.

Godwin AR, Bollag RJ, Christie DM, Liskay RM. Spontaneous and restriction enzyme-induced chromosomal recombination in mammalian cells. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12554-8. PubMed PMID: 7809076; PubMed Central PMCID: PMC45477.

Godwin AR, Liskay RM. The effects of insertions on mammalian intrachromosomal recombination. Genetics. 1994 Feb;136(2):607-17. PubMed PMID: 8150287; PubMed Central PMCID: PMC1205812.

Bollag RJ, Elwood DR, Tobin ED, Godwin AR, Liskay RM. Formation of heteroduplex DNA during mammalian intrachromosomal gene conversion. Mol Cell Biol. 1992 Apr;12(4):1546-52. PubMed PMID: 1549110; PubMed Central PMCID: PMC369596.

Tsujimura T, Maher VM, Godwin AR, Liskay RM, McCormick JJ. Frequency of intrachromosomal homologous recombination induced by UV radiation in normally repairing and excision repair-deficient human cells. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1566-70. PubMed PMID: 2154752; PubMed Central PMCID: PMC53516.