Mark D. Zabel
Assistant Professor

Phone: 491-1455
Fax: 491-0603
Email: Mark.Zabel@ColoState.EDU
Office: 227 Pathology Building
Lab: 218 Pathology Building

 

Degrees

• BA, Loyola University of Chicago, 1990
• MS, Southern Illinois University, 1995
• PhD, University of Utah, 2001

Postdoctoral Training

• Neuropathology Institute, University Hospital of Zürich, Switzerland

Research Interests

• My main area of interest lies in prion immunology. This includes deciphering the cellular and molecular mechanisms of prion accumulation and replication in lymphoid organs, with the ultimate goal of developing therapeutic strategies to ablate subsequent neuroinvasion and disease transmission. Precisely, I will extend my current work investigating the role of Complement in peripheral prion pathogenesis of mouse scrapie by developing mouse models suitable for studying Chronic Wasting Disease. I will also explore further the molecular mechanisms of prion accumulation and replication in mouse scrapie using established murine models.

Selected Publications

Pub Med for Zabel MD.

• Jouvin-Marche E, Attuil-Audenis V, Aude-Garcia C, Rachidi W, Zabel M, Podevin-Dimster V, Siret C, Huber C, Martinic M, Riondel J, Villiers CL, Favier A, Naquet P, Cesbron JY, Marche PN. (2006) Overexpression of Cellular Prion Protein Induces an Antioxidant Environment Altering T Cell Development in the Thymus. Journal of Immunology 176(60):3490-97.
• Mark D. Zabel, Isabelle Arrighi, Jan Kranich, Petra Schwarz, Adriana von Teichman, Karen M. Haas, Christian Dumpitak, Nicolas Zeller, Mathias Heikenwalder, Tom F. Tedder, John H. Weis and Adriano Aguzzi: The Complement Receptor, CD21/35, Is The Lymphoid Prion Receptor. Manuscript in preparation.
• Mark Zabel, Christoph Huber, Marianne Martinic, Adriana von Teichman, Sei-ichi Yusa, Adriano Aguzzi: Overexpression Of The Cellular Prion Protein On T Cells Decreases Thymus Size And Cellularity. Manuscript in preparation.
• Karen M. Haas, Minoura Hasegawa, Douglas A. Steebler. Johnathan C. Poe, Mark D. Zabel, Cheryl B. Brock, David R. Karp, David E. Briles, John H. Weis and Thomas F. Tedder: Complement Receptors CD21/35 Link Innate And Protective Immunity During Streptococcus Pneumoniae Infection By Regulating Igg3 Antibody Responses Immunity (2002) 17: 713-723.
• Mark D. Zabel, Wells Wheeler, Janis J. Weis and John H. Weis: YY1, Oct–1 and NFAT–4 Form Repeating, Cyclosporin–Sensitive Modules Within the Murine CD21 Intronic Control Region Journal of Immunology (2002) 168: 3341–3350
• Leena Chakravarty, Mark D. Zabel, Janis J. Weis and John H. Weis: Depletion of Lyn Kinase from the BCR Complex and Inhibition of B Cell Activation by Excess CD21 Ligation. International Immunology (2001) 14(2):139-46.
• Mark D. Zabel and John H. Weis: Cell Specific Regulation of the CD21 Gene (2000) International Immunopharmacology (review)(1): 473-483
• Mark D. Zabel, Burke L. Byrne, Janis J. Weis and John H. Weis: Cell-Specific Expression Of The Murine CD21 Gene Depends On Accessibility Of Promoter And Intronic Elements Journal of Immunology (2000) Oct 15;165(8):4437-45.