Mary Anna Thrall
Professor

Phone: 491-7508
Fax: 491-0603
Email: MaryAnna.Thrall@colostate.edu
Office: 316 Pathology Building
Lab: Clinical Pathology Laboratory, VTH

 

Degrees

• BA, University of Evansville, 1966
• DVM, Purdue University, 1970
• MS, Colorado State University, 1977

Board Certifications

• Diplomate, American College of Veterinary Pathologists, Clinical Pathology

Research Interests

• Dr. Thrall's research interests include:
  –Pathophysiology and experimental treatment, specifically bone marrow transplantation in feline models of lysosomal storage diseases. A feline model of Nieman Pick C has been established, and is currently utilized to study pathophysiology and therapy of NPC
  –Pathophysiology and therapy of ethylene glycol toxicoses
  –Clinical hematology and cytology

Selected Publications

Pub Med for Thrall MA.

• Gasper PW, Thrall MA, Wenger DA, Macy DW, Ham L, Dornsife RE, Quackenbush SL, Kesel ML, Gillette EL, and Hoover EA: Correction of feline arylsulfatase B deficiency (mucopolysaccharidosis VI) by bone marrow transplantation. Nature 312:467-469, 1984.
• Thrall MA, Dial SM, and Winder DR: Identification of calcium oxalate monohydrate crystals by x-ray diffraction in urine of ethylene glycol intoxicated dogs. Vet Pathol 22:625-628, 1985.
• Dial SM, Thrall MA, and Hamar DW: The use of 4-methylpyrazole as treatment for ethylene glycol intoxication in the dog. J Am Vet Med Assoc 195:73-76, 1989.
• Colgan SP, Thrall MA, Gasper PW, Gould DH, Rose BJ, Fulton R, Blancquaert AMB, and Bruyninckx WJ: Reversal of neutrophil mobility defect and platelet pool deficiency in feline Chediak-Higashi Syndrome with bone marrow transplantation. Bone Marrow Transplant 7:101-110, 1991.
• Jain NC, Blue JT, Grindem CB, Harvey JW, Kociba GJ, Krehbiel JD, Latimer KS, Raskin RE, Thrall MA, and Zinkl JG: Proposed criteria for classification of acute myeloid leukemias in dogs and cats - a report of the animal leukemia study group. Vet Clin Pathol 20:63-82, 1991.
• Colgan SP, Blancquaert AMB, Bruyninckx WJ, Thrall MA, and Gasper PW: Defective in vitro motility of polymorphonuclear leukocytes of homozygote and heterozygote Chediak-Higashi cats. Vet Immunol Immunopathol 31:205-227, 1992.
• Walkley SU, Thrall MA, Dobrenis K, Huang M, March PA, Siegel DA, and Wurzelman S: Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage disease. Proc Natl Acad Sci USA 91:2970-2974, 1994.
• Brown DE, Thrall MA, Walkley SU, Mitchell TW, Wenger DA, Smith MO, Royals KL, and March P: Animal model of human disease: Feline Niemann-Pick Type C. Am J Pathol 144:1412-1415, 1994.
• Connally HE, Thrall MA, Forney SD, Grauer GF, and Hamar DW: Safety and efficacy of 4-methylpyrazole as treatment for suspected or confirmed ethylene glycol intoxication in dogs: 107 cases (1983-1995). J Am Vet Med Assoc 209:1880-1883, 1996.
• Walkley SU, Thrall MA, and Dobrenis K: Targeting gene products to the brain and neurons using bone marrow transplantation: A cell-mediated delivery system for therapy of inherited metabolic human disease. In: Gene transfer into neurons: Towards gene therapy of neurological disorders. Lowenstein P, Enquist L, (eds). John Wiley & Sons, Sussex, England, pp 275-302, 1996.
• Dial SM, Byrne T, Gasper PW, Rose BJ, Haskins ME, Wenger DA, and Thrall MA: Urine glycosaminoglycans concentrations in mucopolysaccharidosis VI affected cats following bone marrow transplantation or leukocyte infusion. Clin Chim Acta 263:1-14, 1997.
• March PA, Thrall MA, Brown DE, Mitchell TW, Lowenthal AC, and Walkley SU: GABAergic neuroaxonal dystrophy and other cytopathological alterations in feline Niemann-Pick disease type C. Acta Neuropathol 94:164-172, 1997.
• Thrall MA, and Haskins ME: Bone marrow transplantation. In: Consultations in feline internal medicine, 3rd volume. August JR (ed). WB Saunders Company, Orlando, pp 514-524, 1997.
• Walton RM, Brown DE, Hamar DW, Meador VP, Horn JW, Thrall MA: Mechanisms of echinocytosis induced by Crotalus atrox venom. Vet Path 34:442-449, 1997.
• Haskins, M., Abkowitz, J., Aguirre, G., Casal, M., Evans, S.M., Hasson, C.,Just, C., Lexa, F., Miranda, S., Schuchman, E., Simonaro, C., Thrall, M.A.,Wang, P., Weil, M., Weimelt, S., Wolfe, J., and Patterson, D. Bone marrow transplantation in animal models of lysosomal storage diseases. In Correction of Genetic Diseases by Transplantation IV. O. Ringden, J. R. Hobbs, and C. G. Steward (eds). COGENT press, Middlesex, G. B. 1-11, 1997.
• Thrall MA, Connally HE, Dial SM, Grauer GF: Advances in Therapy for Antifreeze Poisoning. California Veterinarian 52: 18-22, 1998
• Somers KL, Royals MA, Connally HE, Kelly T, Kimball R, Carstea ED, Wenger DA, Thrall MA: Complementation studies in human and feline Niemann-Pick Type C Disease. Molecular Genetics and Metabolism 66: 117-121, 1999.
• Connally HE, Hamar DW, Thrall MA: Inhibition of canine and feline alcohol dehydrogenase activity by fomepizole. Am J Vet Res 61:450-455, 2000.
• Schultheis P, Gardner SA, Owens JM, Wenger DA, Thrall MA: Mucopolysaccharidosis VII in a cat. Vet Pathol 37:502-505, 2000.
• Somers KL, Brown DE, Allison RA, Fulton R, Just C, Connally HE, Mitchell TW, Schultheiss P, Hamar D, Wenger DA, Thrall MA: Effects of dietary cholesterol restriction in a feline model of Niemann-Pick type C disease. J Inherited Metabolic Disease 24: 427-436, 2001
• Zervas M, Somers K, Thrall MA, Walkley SU: Critical Role for glycospingolipids in Niemann-Pick Disease type Current Biology 11: 1283-1287, 2001
• Garver WS, Somers K, Krishnan K,Heidenreich RA, Mitchell TW, Thrall MA: The Niemann-Pick C1 Protein in Feline Fibroblasts. Molecular Genetics and Metabolism. 2002 76:31-36.
• Somers KL, Royals MA, Carstea ED, Rafi MA, Wenger DA, Thrall MA. Mutation analysis of feline Niemann-Pick C1 disease. Mol Genet Metab 2003;79:99-103.
• Thrall MA, Grauer GF, Dial SM: Ethylene Glycol Toxicosis. In The 5 MinuteVeterinary Consult, Second Edition,ed Tilley LP, Smith FWK. Lippincott, Williams & Wilkins, 2000
• Thrall MA: Mucopolysaccharidosis. In The 5 MinuteVeterinary Consult,Second Edition, ed Tilley LP, Smith FWK. Lippincott, Williams & Wilkins, 2000
• Thrall MA: Mucopolysaccharidosis. In Consultations in Feline Internal Medicine, Fourth Edition. JR August, editor. WB Saunders Company, Philadelphia, 2000, pages 450-459.
• Thrall MA, Grauer GF, Connally HE, Hamar D: Ethylene Glycol. Small Animal Toxicology. Edited by P Talcott and M Peterson. WB Saunders, Philadelphia, 2000, pages 484-504.
• Gasper PW, Thrall MA: Hematopoietic Stem Cell Transplantation in Schalm's Veterinary Hematology, 5th edition, BF Feldman, JG Zinkl, NC Jain editors, Lippincot, Williams, and Wilkins, Baltimore, 2000, pages 97-107.
• Thrall MA, Weiser MG: Hematology. In Laboratory Procedures for Veterinary Technicians. 4th edition, edited by Charles Hendrix. Mosby-Year Book, Inc., 2002
• Thrall MA, Baker D. Campbell T, DeNicola D, Fettman M, Lassen D, Rebar A Weiser G: Veterinary Hematology and Clinical Chemistry. In press, Lippincott, Williams, & Wilkins, 2003.