Alan R. Schenkel
Assistant Professor

Phone: 491-2926
Fax: 491-1815
Email: Alan.Schenkel@colostate.edu
Office: B207 Microbiology Building
Lab: B227 Microbiology Building
Website: http://www.cvmbs.colostate.edu/mip/leukocytomics/

 

Degrees

• BA, University of Colorado , Boulder , 1993
• PhD, University of Wisconsin , Madison , 1998

Postdoctoral Training

• Weill Medical School of Cornell University, New York, NY

Research Interests

• Dr. Schenkel studies the roles of adhesion molecules in leukocyte extravasation (exit from blood into tissues) in response to inflammation. Many of these molecules control how different populations of leukocytes, such as monocytes or lymphocytes, can respond spatially and temporally to infection and disease.

Selected Publications

Pub Med for Schenkel AR.

• Gregg AJ, Schenkel AR. Cloning and structural analysis of equine Platelet Endothelial Cell Adhesion Molecule (PECAM, CD31) and Vascular Cell Adhesion Molecule-1 (VCAM-1, CD106). Veterinary Immunology and Immunopathology 122 (2008) 295-308.
• Schenkel AR, Dufour EM, Chew TW, Sorg E, Muller WA. The Murine CD99-Related Molecule CD99-Like 2 (CD99L2) Is an Adhesion Molecule Involved in the Inflammatory Response. Cell Commun Adhes. 14:227-37. 2007
• Alan R. Schenkel and Minsoo Kim Lymphocyte Function-Associated antigen-1 (LFA-1) and Macrophage antigen-1 (Mac-1): Cooperative Partners in Leukocyte Emigration and Function. In Progress in Inflamation Research - Adhesion Molecules: Function and Inhibition. Klaus Ley (Editor) Birkhauser Verlag AG (2007)
• Alan R. Schenkel, Eric M. Dufour, Tina W. Chew, Emily Sorg, and William A. Muller The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response. Cell Communication and Adhesion In Press (2007)
• Alan R. Schenkel, Tina W. Chew, Elizabeth Chlipala, Marcus W. N. Harbord, and William A. Muller. Different susceptibilities of PECAM deficient mouse strains to spontaneous idiopathic pneumonitis. Experimental and Molecular Pathology 81:21-30 (2006)
• Alan R. Schenkel, Tina W. Chew, and William A. Muller. Platelet Endothelial Cell Adhesion Molecule Deficiency or Blockade Significantly Reduces Leukocyte Emigration in a Majority of Mouse Strains. Journal of Immunology 173:6403-6408 (2004)
• Alan R. Schenkel, Zahra Mamdouh, and William A. Muller Locomotion of Monocytes on Endothelium is a Critical Step During Extravasation. Nature Immunology 5: 393-400 (2004)
• Alan R. Schenkel, Zahra Mamdouh, Xia Chen, Ronald M. Liebman, and William A. Muller CD99 Plays a Major Role in the Migration of Monocytes through Endothelial Junctions. Nature Immunology 3: 143-150 (2002)
• Fang Liao, Alan R. Schenkel, and William A. Muller Transgenic Mice Expressing Different Levels of Soluble Platelet/Endothelial Cell Adhesion Molecule-IgG Display Distinct Inflammatory Phenotypes. Journal of Immunology 163:5640-5648 (1999)
• Alan R. Schenkel and C. David Pauza Pertussis Toxin Treatment In vivo Reduces Surface Expression of the Adhesion Integrin Leukocyte Function Antigen-1 (LFA-1). Cell Adhesion and Communication 7:183-193 (1999)
• Alan R. Schenkel, Hideo Uno, and C. David Pauza Asymptomatic Simian Immunodeficiency Virus Infection Decreases Blood CD4+ T Cells By Accumulating Recirculating Lymphocytes In The Lymphoid Tissues. Journal of Virology 73: 601-607 (1999)