Paul R. Avery
Assistant Professor

Phone: 491-7838
Fax: 491-0603
Email: Paul.Avery@colostate.edu
Office: 217 Pathology Building
Lab: Clinical Pathology Laboratory, VTH

 

Degrees

• BS, Cornell University
• VMD, University of Pennsylvania
• PhD, Colorado State University

Board Certifications

• Diplomate, American College of Veterinary Pathologists-Clinical Pathology

Research Interests

• My laboratory studies the early immune events surrounding Feline Immunodeficiency Virus (FIV) infection as a means to better understand the critical elements in the control of lentiviral infections such as HIV. We specifically study CD8+ T lymphocyte and dendritic cell responses to mucosally acquired FIV and the effects that augmenting the innate and cell-mediated immune response have on host control of the virus.
• As a veterinary clinical pathologist I have a specific interest in the enhanced detection and discrimination of lymphomas and leukemias in dogs and cats. We are currently using immunophenotyping and gene microarray analysis to identify prognostic markers in canine lymphocytic leukemias.

Selected Publications

Pub Med for Avery PR.

• Avery, P.R., Hoover, E.A. Gamma interferon/interleukin 10 balance in tissue lymphocytes correlates with down modulation of mucosal feline immunodeficiency virus infection. Journal of Virology 78(8):4011-9, April 2004
• Avery, P.R., Avery A.C. Molecular methods to distinguish reactive and neoplastic lymphocyte expansions. Journal of Veterinary Clinical Pathology, vol 33(4):196-207. December 2004.
• Modiano, J.F., Breen, M., Burnett, R.C., Parker, H.G., Inusah, S., Thomas, R., Avery, P.R., Lindblad-Toh, K., Ostrander, E.A., Cutter, G.A., and Avery, A.C. Distinct B-Cell and T-Cell Lymphoproliferative Disease Prevalence among Dog Breeds Indicates Heritable Risk. Cancer Research vol 65: (13):5654-61, July 2005.
• Siddiqui, F., Li, C., Zhang, X., LaRue, S.M., Dewhirst, M.W., Ullrich, R.L., Avery, P.R. Characterization of a recombinant adenovirus vector encoding heat-inducible feline interleukin-12 for use in hyperthermia-induced gene therapy. International Journal of Hyperthermia, 22(2):117-34, March 2006.
• Siddiqui, F., Li, C., Zhang, X., LaRue, S.M., Poulson, J.M., Avery, P.R., Pruitt, A.F., Zhang, X., Ullrich, R.L., Thrall, D.E., Dewhirst, M.W. and Hauck, M.L., A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. Molecular Cancer Therapeutics 6(1):380-9, January 2007.
• Avery, P.R., Lehman, T.L., Hoover, E.A., and Dow, S.W., Dendritic Cell Progenitors Present in Most Organs of Cats As Demonstrated By Stromal Cell Cultures. Veterinary Immunology and Immunopathology, In press 2007.
• Lehman, T.L., O'Halloran, K.P., Fallon, S.A., Habermann, L.M., Campbell, J.A., Nordone, S., Dean, G.A., Hoover, E.A., Avery, P.R. The Effect of Chronic Feline Immunodeficiency Virus Infection on Dendritic Cell Cytokine Production in Response to Toll-Like Receptor and CD40 Ligation, Manuscript Submitted.