Diane J. Ordway
Assistant Professor

Phone: 491-4117
Fax: 491-1815
Email: D.Ordway-Rodriguez@Colostate.Edu
Office: B109 Microbiology Building
Lab: C312 Microbiology Building

Degrees

B.Sc., Colorado State University, USA
Ph.D., London School of Hygiene & Tropical Medicine, England

Research Interests

Immunology, Vaccines and Drugs against Pathogenic Mycobacteria

Worldwide the rate of drug-sensitive, multi-drug and extensively drug resistant Mycobacterium tuberculosis cases are increasing. The only available vaccine against M. tuberculosis, M. bovis Bacillus Calmette-Guérin (BCG) is unreliable and the use of anti-mycobacterial drugs has only lead to high rates of drug resistance. Primarily I am interested in elucidating the T cell and macrophage/dendritic cellular immune responses against Mycobacterium tuberculosis through the use of novel multi-parameter flow cytometry in murine and guinea pigs models. These animal models are used to test vaccines and drugs and provide us with information on the nature of induction of protective immunity.

I also collaborate with scientists in clinical research focused on elucidation of the immune mechanisms against Mycobacterium abscessus, Mycobacterium avium and Mycobacterium paratuberculosis.

Selected Publications

Pub Med for Ordway D.

M. Henao-Tamayo, G. S. Palaniswamy, E. E. Smith, C. A. Shanley, B.Wang, I. M. Orme, R.J. Basaraba , N.M. DuTeau , D. Ordway. Post-exposure vaccination against Mycobacterium tuberculosis. Tuberculosis 2009. 89:142-148.

D. Ordway, M. Henao-Tamayo, C. Shanley, E. E. Smith, G. Palanisamy, B. Wang, R.J. Basaraba, and I. M. Orme. The influence of BCG vaccination on the cellular immune response in immune guinea pigs infected with Mycobacterium tuberculosis. 2008. Cellular Vaccine Immunology 15: 1248-58.

Ordway, D., G. Palanisamy, M. Henao-Tamayo, E. Smith, C. Shanley, I. M. Orme and R. J. Basaraba. Cellular immune responses during Mycobacterium tuberculosis infection in the guinea pig. 2007. Journal of Immunology 179:2532-41.

Ordway, D., M. Henao-Tamayo, M. Harton, G. Palanisamy, J. Troudt, C. Shanley, R. J. Basaraba, and I. M. Orme. The hypervirulent Mycobacterium tuberculosis strain HN878 induces a potent TH1 response followed by rapid down-regulation. 2007. Journal of Immunology 179:522-31.

Ordway, D., M. Harton, M. Henao-Tamayo, I.M. Orme, and M. Gonzalez-Juarrero. Enhanced macrophage activity in granulomatous lesions of immune mice challenged with Mycobacterium tuberculosis. 2006. Journal of Immunology 176:4931-4939.