Kenneth E. Olson
Professor
Director, Arthropod-borne and Infectious Diseases Laboratory (AIDL)
Phone: 491-8604
Fax: 491-8323
Email:
Kenneth.Olson@colostate.edu
Office: Arthropod-borne & Infectious Disease Laboratory, Foothills Campus
Lab: Arthropod-borne & Infectious Disease Laboratory, Foothills Campus
Degrees
- B.S., North Carolina State University
- M.S., Colorado State University
- Ph.D., Colorado State University
Research Interests
Arbovirus/Mosquito Molecular Biology
- A major research goal is to identify molecular strategies for interfering with the replication of human pathogens in mosquitoes. We have used recombinant mosquito-borne Sindbis viruses to transduce mosquitoes with pathogen-derived RNAs and proteins and stop transmission of the pathogen. We are now developing transgenic mosquitoes that are pathogen resistant. Other important goals are to use and develop new methodologies to identify components of the RNAi pathway in mosquitoes, study the molecular epidemiology of dengue viruses and to identify and characterize important arthropod-borne virus-mosquito interactions.
Selected Publications
Pub Med for Olson KE.
- Hoa N.T., Keene, K.M., Olson K.E. and Zheng, L. (2003) RNA
interference in an Anopheles gambiae cell line. Insect Biochem.
Mol. Biol. 33:949-957.
- Myles K.M., Pierro D.J. and Olson K.E. (2003). Deletions in
the putative cell receptor binding domain of the MRE16 Sindbis E2 glycoprotein
reduce midgut infectivity in Aedes aegypti. J. Virology. 77:8872-8881.
- Pierro D.L., Myles K.M., Foy B.D., Beaty B.J. and Olson K.E.
(2003). Development of a Sindbis virus that allows disseminated expression
of green fluorescing protein in Aedes aegypti following per os
infection. Insect Mol. Biology 12:107-116.
- Adelman Z.N., Travanty E. A., Sanchez-Vargas, I. Carlson J.O., Beaty,
B.J., Blair C.D, and Olson K.E. (2002). RNA silencing of dengue-2
virus replication in transformed C6/36 mosquito cells transcribing an
inverted repeat RNA derived from the virus genome. J. Virology.
76:12925-12933.
