Angelo A. Izzo
Associate Professor

Phone: 491-4350
Fax: 491-1815
Email: Angelo.Izzo@Colostate.Edu
Office: B310A Microbiology Building
Lab: B332 Microbiology Building

Degrees

BSc (Hon), The University of Adelaide
PhD, The University of Adelaide

Research Interests

My lab is interested in studying the immune response to Mycobacterium tuberculosis and tuberculosis vaccines and understanding the interaction between the host and the pathogen. For this we use the mouse and guinea pig models of tuberculosis and employ several techniques to investigate various aspects of the immune response. In addition we collaborate with investigators at CSU and around the world to better understand immunity to vaccines.

An important activity in the lab is testing novel vaccines against M. tuberculosis through the Tuberculosis Vaccine Testing and Research Materials Contract (HHSN266200400091c). If you are interested in this NIAID contract activity, please visit our website at: www.cvmbs.colostate.edu/mip/tb/index.htm.

Selected Publications

Pub Med for Izzo AA.

Kashino, S.S., T. Vallerskog, G. Martens, , J. Troudt, A. Keyser, J. Taylor, A. Izzo H. Kornfeld, and A. Campos-Neto (2009) Initiation of Acquired Immunity in the Lungs of Mice Lacking Lymph Nodes After Infection with Aerosolized Mycobacterium tuberculosis. American Journal of Pathology (In Press)

A. Grover, J. Taylor, J. Troudt, A. Keyser, K. Arnett, D. Rholl and A. A. Izzo (2009) Kinetics of the immune response in guinea pigs after vaccination with BCG and infection with Mycobacterium tuberculosis. Infection & Immunity (In Press)

R. Sun, Y.A.W. Skeiky, A. Izzo, V. Dheenadhayalan, Z. Imam, E. Penn, K. Stagliano, S. Haddock, S. Mueller, J. Fulkerson, C. Scanga, A. Grover, S.C. Derrick, S. Morris, D.M. Hone, M. A. Horwitz, S.H.E. Kaufmann, J.C. Sadoff (2009) Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine 27:4412-23

Xing Z., C.T. McFarland, J.-M. Sallenave, A. Izzo, J. Wang and D.N. McMurray (2009) Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis. PLoS One 4:e5856

Aagaard C., A. Izzo, T. T. K. Thanh Hoang, R. Billeskov, J. Troudt, K. Arnett, A. Keyser, T. Elvang, P. Andersen, and J. Dietrich (2009) Protection and Polyfunctional T cells induced by Ag85B-TB10.4/IC31 against Mycobacterium tuberculosis is highly dependent on the antigen dose. PLoS One 4:e5930

Drumm J.E., K. Mi, P. Bilder, A. Izzo, M.H. Sun, H. Bielefeldt-Ohmann, R. Basaraba, J. Xu, M. So, G. Zhu, J. Tufariello, I. Orme, S.C. Almo, T.S Leyh, J. Chan (2009) Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: Requirement for establishing chronic persistent infection. PLoS Pathogen 5:e100046

Taylor J., H. Bielefeldt-Ohmann, A. Pozzi, and A. A. Izzo (2008) Lack of alpha-1 integrin alters lesion morphology during pulmonary Mycobacterium tuberculosis infection. Tuberculosis 88:444-452

Honaker RW, Stewart A, Schittone S, Izzo A, Klein MR, Voskuil MI. (2008) BCG vaccine strains lack narK2 and narX induction and exhibit altered phenotypes during dormancy. Infection & Immunity 76:2587-2593

Grover A., J. Taylor, J. Troudt, A. Keyser, K. Sommersted, A. Schenkel. A. Izzo (2008) Mycobacterial Infection induces the secretion of High Mobility Group Box 1 (HMGB1) protein. Cellular Microbiology 10:1390-1404