Edward A. Hoover
University Distinguished Professor

Phone: 491-7587
Fax: 491-0523/0603
Email: Edward.Hoover@colostate.edu
Office: 229 Pathology Building
Lab: 221 Pathology Building

 

Degrees

• BS, University of Illinois, 1965
• DVM, University of Illinois, 1968
• MS, The Ohio State University, 1969
• PhD, The Ohio State University, 1970

Board Certifications

• Diplomate, American College of Veterinary Pathologists, Anatomic Pathology

Research Interests

• Dr. Hoover's laboratory focuses on the pathogenesis and intervention for retrovirus and prion infections--in particular the feline and simian immunodeficiency viruses (FIV, SIV), the feline leukemia virus (FeLV), and the prion disease chronic wasting disease (CWD) of deer and elk. These agents are causes of fatal disease in animals and models for human diseases-i.e. HIV infection/AIDS, leukemia, bovine spongiform encephalopathy (mad cow disease, BSE), and Creutzfeld-Jakob disease. Research in the Hoover laboratory led to development of the most widely used vaccine against FeLV infection in cats. Current work focuses on: (1) the mechanisms whereby FIV crosses the mucous membranes and infects initial target cells, (2) the role of early innate and acquired immunity in containing or failing to contain FIV infection, (3) transmission, shedding and detection of the CWD prion in deer, transgenic mice, and other species, and (4) experimental vaccination for prion infections.

Selected Publications

Pub Med for Hoover EA.

• Mathiason, Candace K., Jenny G. Powers, Sallie J. Dahmes, David A. Osborn, Karl V. Miller, Robert J. Warren, Gary L. Mason, Sheila A. Hays, Jeanette Hayes-Klug, Davis M. Seelig, Margaret A. Wild, Lisa L. Wolfe, Terry R. Spraker, Michael W. Miller, Christina J. Sigurdson, Glenn C. Telling, and Edward A. Hoover. Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease. Science 6 Oct 2006, Vol 314, 5796, pp 133-136. Abstract Full Text
• Troth, Sean P., Alan D. Dean, and Edward A. Hoover. In vivo CXCR4 expression, lymphoid cell phenotype, and feline immunodeficiency virus infection. Submitted, 2006, J. Virol.
• Sigurdson, Christina J., Candace K. Mathiason, Matthew R. Perrott, Gwyneth A. Eliason, Terry R. Spraker, Markus Glatzel, Jason C. Bartz, Michael W. Miller and Edward A. Hoover. Experimental chronic wasting disease (CWD) in the ferret. Submitted, 2006, J. Comp. Path.
• Angers, Rachel, Shawn Browning, Tanya Seward, Christina Sigurdson, Michael W. Miller, Edward A. Hoover, Glenn C. Telling Prions in Skeletal Muscles of Deer with Chronic Wasting Disease. Science. Feb 24;311(5764):1117, 2006.
• Burkhard MJ, Hoover EA: IgG from acutely infected cats blocks mucosal feline immunodeficiency virus infection. Vet Immunol Immunopathol 15;106(1-2):87-95, 2005.
• Sprague, WS, Pope, M, and Hoover, EA: Culture and characterization of feline myeloid dendritic cells. J. Comp. Path.133:136-145, 2005.
• Torres, AN, Mathiason, CK, and Hoover, EA: Reassessement of host-virus relationships in feline leukemia virus infection using realtime PCR. 332(1):272-83, Virology, Jan. 2005
• deRozières, Sohela, Candace K. Mathiason, Matthew R. Rolston, Udayan Chatterji, Edward A. Hoover, and John H. Elder. Characterization of a pathogenic molecular clone of FIV-clade C. J Virol. 8971-82, 2004
• Browning, S., Seward, T., Green, M. Miller, M, Williams, Sigurdson, C. J., E, Elliason, GA., Mathiason, CK, Mason, GL, Hoover, EA. and Telling, GC: Transmission of chronic wasting disease to transgenic mice expressing the cervid PrP. J Virol. 13345-50, 2004.
• Avery, PR, and Hoover, E.A.: Gamma interferon/interleukin 10 balance in tissue lymphocytes correlates with down modulation of mucosal feline immunodeficiency virus infection. J Virol. 78(8):4011-4019, 2004.
• Allison, R.W. and Hoover, E.A.: Covert vertical transmission of feline immunodeficiency virus. AIDS Research Human Retroviruses, 19: 429-434, 2003.
• Allison, R.W. and Hoover, E.A.: Feline immunodeficiency virus is concentrated in milk early in lactation. AIDS Research Human Retroviruses 9:245-53, 2003.
• Rogers, A.B. and Hoover, E.A.: Immunohistochemical localization of feline immunodeficiency virus using native species antibodies. Amer. J. Pathol., 161:1143-1151, 2002.
• Rogers, A.B. and Hoover, E.A.: Fetal feline immunodeficiency virus infection is prevalent and occult. J. Infect. Disease, 895-904, 2002.
• Sigurdson, C.J., Barillas-Mury, C., Miller, M.W., Oesch, B. van Keulen, L.J.M., Langeveld, J.P.M., and Hoover, E.A. PrPCWD lymphoid cell targets in early and advanced chronic wasting disease in mule deer. J. Gen. Virol., 2617-2628, 2002.
• Obert, L.A., Hoover, E.A.: Early pathogenesis of mucosal feline immunodeficiency virus infection. J. Virol. 76: 6311-6322, 2002.