Mercedes Gonzalez-Juarrero
Assistant Professor

Phone: 491-7306
Fax: 491-5125
Email: Mercedes.Gonzalez-Juarrero@colostate.edu
Office: B308B Microbiology Building
Lab: C312 Microbiology Building

 

Degrees

• BS Universidad Complutense de Madrid, Spain
• PhD Universidad Autonoma de Madrid, Centro de Biologia Molecular, Spain

Research Interests

• Our interest is to study the basic nature of the cell mediated immune response to mycobacteria infections. Currently our research is focused on the role and dynamics of macrophage and dendritic cell populations during the early and late stages of infection with Mycobacterium tuberculosis. We have recently defined changes in the macrophage cell populations in the lung during the course of pulmonary tuberculosis. Nowadays we are expanding our basic research towards definition of differences in the origin and function of macrophage cell populations derived from mucosal and lymphoid organs. The main aim of this research is to associate particular characteristics from each macrophage cell subset derived from different organs with the development of adaptive immunity, inflammatory responses and susceptibility to mycobacteria infections.

Selected Publications

Pub Med for Gonzalez-Juarrero M.

• Gonzalez-Juarrero M. and Orme IM., Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis. (2001) Infection and Immunity 69 (2): 1127-33.
• Gonzalez-Juarrero M., Turner OC., Turner J., Marietta P., Brooks JV., Orme IM., Temporal and spatial arrangements of lymphocytes within lung granulomas induced by aerosol infection with Mycobacterium tuberculosis. (2001) Infection and Immunity 69 (3):1722-8
• Turner J., Frank AA., Brooks JV. Gonzalez-Juarrero M., Orme IM., The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4 . (2001) Experimental Gerontology 36 (3):537-45
• Turner J., Gonzalez-Juarrero M., Saunders BM., Brooks JV., Marietta P., Ellis DL., Frank AA., Cooper AM., Orme IM., Immunological basis of reactivation of reactivation of tuberculosis in mice (2001) Infection and Immunity 69 (5) 3264-70.
• Turner J., Gonzalez-Juarrero M., Ellis DL., Basaraba RJ., Kipnis A., Orme IM., Cooper AM., In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. (2002) Journal of Immunology, 169: 6343-6351.
• Roberts, AD., Belisle, JT., Turner J., Gonzalez-Juarrero M., Cooper AM. and Orme IM., (2002) Murine models of tuberculosis, In Methods in Microbiology, Vol 32 (Kaufman SHE) Academic Press Ltd, pag 433-462.
• Gonzalez-Juarrero, M., J. Turner, R.J. Basaraba, J.B. Belisle and I.M. Orme. Florid pulmonary inflammatory responses in mice vaccinated with Antige-85 pulsed dendrtic cells and challenged by aerosol with Mycobacterium tuberculosis (2002). Cellular Immunology. 220: 13-19
• Gonzalez-Juarrero, M., Tae Sun Shim, Andre Kipnis, Ana Paula Junqueira-Kipnis, and Ian M. Orme. Dynamics of Macrophage Cell Populations During Murine Pulmonary Tuberculosis. (2003) Journal of Immunology 171: 3128-3135.
• Junqueira-Kipnis A, P., Joanne Turner, Gonzalez-Juarrero, M., Oliver C Tuner and Ian M. Orme. A stable T cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis. (2003) Infection and Immunity (in press).
• Junqueira-Kipnis AP, Andre Kipnis, Amanda Jamieson, Mercedes Gonzalez Juarrero, Andreas Diefenbach, David H Raulet, Joanne Turner and I M Orme. NK cells respond to pulmonary infection with Mycobacterium tuberculosis but play a minimal role in protection. (2003) Journal of Immunology. (in press)