Steven W. Dow
Professor

Phone: 491-6146
Fax: 491-0603
Email: Steven.Dow@colostate.edu
Office: 327 Pathology Building
Lab: 304 Pathology / Infectious Disease Annex, Foothills Campus

 

Degrees

• BA, University of Virginia
• DVM, University of Georgia
• PhD, Colorado State University, Dept of Pathology

Current Staff

• Laboratory Manager: Abby Jones
• Research Scientists: Ryan Troyer
• Post-Doctoral Fellows: Amanda Guth
• Graduate students: Andrew Goodyear, Joe Sottnik, Angie Duffy, Katie Probst, Lisa Kellihan, Scott McCorvey, Shayna Warner.
• Student hourlies: Linda Strange, Amber Troy

Research Interests and Current Projects

• Our laboratory studies the role of innate immunity in the development and progression of cancer and in the pathogenesis of bacterial infections, including the agents Burkholderia, Yersinia and Francisella. In addition, the laboratory is investigating the use of novel immunotherapeutics to treat or prevent bacterial and viral infections and cancer and in the development of new vaccine adjuvants.

Current projects in the laboratory include:
• Role of innate immunity in the pathogenesis of pneumonic Burkholderia infection
• Development of an orally-administered vaccine for pneumonic plague
• Use of TLR-based immunotherapeutics for prevention of Francisella and Burkholderia infections.
• Use of TLR-based immunotherapeutics for treatment of local and metastatic cancer
• Role of interferons and macrophages in regulation of tumor growth
• Role of bone infection in prevention of tumor metastasis

Selected Publications

Pub Med for Dow S.

1. Sellins K, Fradkin L, Liggitt D, and Dow S. (2005). Type I interferons potently suppress gene expression following gene delivery using liposome-DNA complexes. Mol Therapy 12:451-459.
2. Bosio C, Goodyear A, and Dow S. (2005) Early interaction of Yersinia pestis with APCs in the lungs. J Immunol 175:6750-6756.
3. Bosio C and Dow S. (2005) Aberrant activation of pulmonary dendritic cells by Francisella tularensis. J Immunol 175:6792-6801.
4. Kamstock D, Guth A, Elmslie R, Kurzman I, Fairman J, Coro L, and Dow S. (2006) Liposome-DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma. Cancer Gene Ther 13, 306-317.
5. Gowen B, Fairman J, Smee D, Wong M, Jung K, Pace A, Heiner M, Bailey K, Dow S, and Sidwell R. (2006) Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes. Antiviral Research 69:165-172.
6. U'Ren L, Kedl R, and Dow S. (2006) Immunization with liposome-DNA complexes elicits enhanced antitumor immunity. Cancer Gene Ther 13:1033-1044.
7. Zaks K, Jordan M, Guth A, Sellins K, Kedl R, Izzo A, Bosio C, and Dow S. (2006) Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 and TLR9 agonists complexed to cationic liposomes. J Immunol 176:7335-7345.
8. Mathes M, Jordan M, and Dow S. (2006) Evaluation of liposomal clodronate in a canine model of spontaneous autoimmune hemolytic anemia. Expt Hematol, 34:1393-1404.
9. McMahon RH, Williams JA, Jordan KR, Dow SW, Wilson DB, and Slansky JE. (2006) Relating MHC-Peptide, TCR affinity to immunogenicity for the rational design of tumor vaccines. J Clin Invest 116:2543-2551.
10. Biller B, Elmslie R, Burnett R, Avery A, and Dow S. (2007) Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Vet Immunol Immunopath, 116:69-78.
11. Kamstock D, U'Ren L, Elmslie R, Lana S, Thamm D, and Dow S. (2007) Evaluation of a xenogeneic VEGF vaccine in dogs with soft tissue sarcoma. Cancer Immunol Immunother 56:1299-1309.
12. Avery P, Lehman T, Hoover E, and Dow S. (2007) Sustained generation of dendritic cells from multiple tissues of cats using long-term stromal cell cultures. Vet Immunol Immunother 117:222-235.