James C. DeMartini
Professor Emeritus

Phone: 491-5410
Fax: 491-0603
Email: James.Demartini@colostate.edu
Office: 232 Pathology Building

 

Degrees

• BS, University of California-Davis, 1964
• DVM, University of California-Davis, 1966
• PhD, University of California-Davis, 1972

Board Certifications

• Diplomate, American College of Veterinary Pathologists, Anatomic Pathology
• Alumni Achievement Award, School of Veterinary Medicine, University of California, Davis, 2001

Research Interests

• Dr. DeMartini is interested in the pathogenesis and control of infectious diseases, particularly viral diseases of ruminant animals. The work in his laboratory emphasizes studies of pathogenesis and protective or pathogenic immune responses. Viral systems he has investigated include retroviruses, bunyaviruses, herpesviruses, parvoviruses, and poxviruses. Some research has been conducted in overseas sites such as East Africa and South America.
• Current work focuses on viral pathogenesis of a retrovirus-induced disease of sheep (ovine pulmonary adenocarcinoma), a herpesvirus infection of cattle (malignant catarrhal fever), and a novel coronavirus infection of humans (sudden acute respiratory syndrome-SARS). These diseases are studied as models of human disease or as economically important diseases for the livestock industry. Research in Dr. DeMartini's laboratory involves applicable techniques at the molecular, biochemical, cellular, and whole animal levels.

Selected Publications

Pub Med for DeMartini JC.

• DeMartini JC, and Baldwin CL: Effects of gamma interferon, tumor necrosis factor alpha, and interleukin-2 on infection and proliferation of Theileria parva-infected bovine lymphoblasts and production of interferon by parasitized cells. Infect Immun 59:4540-4546, 1991.
• Brodie SJ, Marcom KA, Pearson LD, Anderson BC, de la Concha-Bermijillo A, Ellis JA, and DeMartini JC: Effects of virus load in the pathogenesis of lentivirus-induced lymphoid interstitial pneumonia. J Infect Dis 166:531-541, 1992.
• DeMartini JC, MacHugh ND, Naessens JG, and Teale AJ: Differential in vitro and in vivo expression of MHC class II antigens in bovine lymphocytes infected by Theileria parva. Vet Immunol Immunopathol 35:253-273, 1992.
• DeMartini JC, Brodie SJ, de la Concha-Bermijillo A, Ellis JA, and Lairmore MD: The pathogenesis of lymphoid interstitial pneumonia in natural and experimental ovine lentivirus infection. Clin Infect Dis 1:S236-S242, 1993.
• DeMartini JC, Bickle HM, Brodie, SJ, He BX, and Esposito JJ: Raccoon poxvirus rabies virus glycoprotein recombinant vaccine in sheep. Arch Virol 133:211-222, 1993.
• Hecht SJ, Carlson JO, and DeMartini JC: Analysis of a type D retroviral capsid gene expressed in ovine pulmonary carcinoma and present in both affected and unaffected sheep genomes. Virology 202:480-484, 1994.
• Brodie SJ, Pearson LD, Zink MC, Bickle HM, Anderson BC, Marcom KA, and DeMartini JC: Ovine lentivirus expression and disease: Virus replication, but not entry, is restricted to macrophages of specific tissues. Amer J Pathol 146:250-263, 1995.
• de la Concha-Bermejillo A, Brodie SJ, Magnus-Corral S, Bowen RA, and DeMartini JC: Pathologic and serologic responses of isogeneic twin lambs to phenotypically distinct lentiviruses. J Acquir Immune Defic Syndr Hum Retrovirol 8:116-123, 1995.
• Woodward TM, Carlson JO, de la Concha-Bermejillo A, and DeMartini JC: Change in cell culture phenotype of ovine lentivirus strains following passage in isogeneic twin lambs. J Acquir Immune Defic Syndr Hum Retrovirol 8:124-133, 1995.
• O'Toole D, Li H, Roberts S, Rovnak J, DeMartini J, Cavender J, Williams B, and Crawford T: Chronic generalized obliterative arteriopathy in cattle: A sequel to sheep-associated malignant catarrhal fever. J Vet Diagn Invest 7:108-121, 1995.
• Hecht SJ, Stedman KE, Carlson JC, and DeMartini JC: Distribution of endogenous type B and type D retroviral sequences in ungulates and other mammals. Proc Natl Acad Sci USA 93:3297-3302, 1996.
• Bai J, Zhu R-Y, Stedman K, Cousens C, Carlson JC, Sharp JM, and DeMartini JC: Unique LTR U3 sequences distinguish exogenous jaagsiekte sheep retroviruses associated with ovine pulmonary carcinoma from endogenous loci in the sheep genome. J Virol 70:3159-3168, 1996.
• Rwambo PM, Shaw MK, Rurangirwa FR, and DeMartini JC: Ultrastructural studies on the replication and morphogenesis of Nairobi sheep disease virus, a Nairovirus. Arch Virol 141:1479-1492.
• Mwaengo DM, Grant RF, DeMartini JC and Carlson JO: Envelope glycoprotein nucleotide sequences and genetic characterization of North American ovine lentiviruses. Virology 238:135-144, 1997.
• Halsey WA, Palmer BE, DeMartini JC, and Howell MD: Analysis of ovine T cell receptor - chain heterogeneity. Immunogenetics 49:206-214, 1999.
• Bai J, Bishop JV, Carlson JO, and DeMartini JC: Sequence comparison of JSRV with endogenous proviruses: Envelope genotypes and a novel ORF with similarity to a G-protein coupled receptor. Virology, in press, 1999.
• Cheevers, W.P., R. Cordery-Cotter, T.C. McGuire, and J.C. DeMartini. Neutralizing antibody responses and evolution of antigenic variants in isogeneic twin lambs infected with phenotypically distinct ovine lentiviruses. Virology 258:382-388, 1999.
• DeMartini, J.C., W. Halsey, C. Boshoff, D. York, and M.D. Howell. Comparison of a maedi-visna virus CA-TM fusion protein ELISA with other assays for detecting sheep infected with North American ovine lentivirus strains. Vet Immunol Immunopathol. 71: 29-40, 1999.
• Rai, S.K., J.C. DeMartini, and A.D. Miller. Retrovirus vectors bearing jaagsiekte sheep retrovirus env transduce human cells by using a new receptor localized to chromosome 3p21.3. J. Virology 74:4698-4704, 2000.
• DeMartini, J.C., J.V. Bishop, T.E. Allen, F.A. Jassim, J.M. Sharp, M. DeLas Heras, D.R. Voelker, and J. O. Carlson. Jaagsiekte sheep retrovirus proviral clone JSRVJS7, derived from the JS7 lung tumor cell line, induces ovine pulmonary carcinoma and is integrated into the surfactant protein A gene. J. Virology 75:4239-4246,2001.
• Dunowska, M., G.J. Letchworth, J.K.Collins, and J.C. DeMartini. Ovine herpesvirus-2 glycoprotein B sequences from tissues of ruminant malignant catarrhal fever cases and healthy sheep are highly conserved. J. Gen. Virol. 82:2785-2790, 2001.
• Platt, J., Villafane, F., Kraipowich, N., and J.C. DeMartini. Alveolar type II cells expressing jaagsiekte sheep retrovirus capsid protein and surfactant proteins are the predominant neoplastic cell type in ovine pulmonary adenocarcinoma. Vet. Pathol. 39:341-352, 2002.
• Allen, T. E., K. J. Sherrill, S.M. Crispell, M.R. Perrott, J.O. Carlson and J.C. DeMartini. The jaagsiekte retrovirus envelope gene induces transformation of the avian embryo fibroblast cell line DF-1 but does not require a conserved SH2 binding domain. J. Gen. Virol. 83:2733-2742, 2002.
• Keane, K.K., G.M. Mason, and J. C. DeMartini. 2002. Inhibition of nitric oxide enhances ovine lentivirus replication in monocyte-derived macrophages. Vet. Immunol. Immunopath. 90:179-89,2002.
• Carlson, J.O., M. Lyon, J. Bishop,1 A. Vaiman, E. Cribiu,J-F. Mornex, S. Brown, D. Knudson, J. DeMartini, and C. Leroux. Chromosomal distribution of endogenous jaagsiekte sheep retrovirus proviral sequences in the sheep genome. J. Virol. 77: 9662-9668, 2003.