Mary Ann DeGroote
Assistant Professor
Phone: 491-2531
Fax: 491-1815
Email:
MaryAnn.DeGroote@ColoState.edu
Office: B108 Microbiology Building
Lab: C312 Microbiology Building
Degrees
B.A. University of Northern Iowa
M.D. University of Iowa
Medical Residency, University of Colorado Health Sciences Center
Infectious Disease Fellowship, University of Colorado Health Sciences Center
Licensure and Certifications
Colorado State Board of Medical Examiners
Diplomat, American Board of Internal Medicine, Internal Medicine
Board Certification Examination in Infectious Diseases
Summary of Key Interests
Bill and Melinda Gates TB Drug Accelerator Grant - Assay Standardization Website
Diagnosis and treatment of human mycobacterial infections, including molecular detection of mycobacteria and pre-clinical testing of medications for tuberculosis and nontuberlous mycobacteria using animal models
Translational research in human and animal mycobacterial diseases.
Mycobacterium tuberculosis and Mycobacterium abscessus pre-clinical drug development.
Clinical expertise in infectious diseases of humans
Rapid diagnosis of infection and disease due to Mycobacteria spp.
Selected Publications
Pub Med for DeGroote MA.
De Groote, M.A., M.A. Martin, P. Densen, M.A. Pfaller, R.P. Wenzel. Plasma Tumor Necrosis Factor Levels in Patients with Presumed Sepsis. JAMA, 1989;262(2): 249-51.
De Groote, M.A., G. Visvesvara, M.L. Wilson, N.J. Pieniazek, S.B. Slemenda, A.J. DaSilva, G.J. Leitch, R.T. Bryan, R. Reves. PCR and Culture Confirmation of Disseminated Encephalitozoon cuniculi in a patient with AIDS:Successful therapy with Albendazole. Journal of Infectious diseases, 1995;171:1375.
De Groote, M.A., F.C. Fang. NO inhibitions: Antimicrobial Activity of Nitric Oxide. Clinical Infectious Diseases, 1995;21(Suppl 2):S162-5.
De Groote, M.A., D. Granger, Y. Xu, G. Campbell, R. Prince, F.C. Fang. Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model. Proc Natl Acad Sci U.S.A.,1995;92:6399-6403.
Didier, E.S., G.S. Visvesvara, M.D. Baker, L.B. Rogers, D.C. Bertucci, M.A. De Groote, C.R. Vossbrink. A Microsporidian isolated from an AIDS patient corresponds to the Encephalitozoon cuniculi strain III originally isolated from domestic dogs. J Clin Micro, 1996;34:2835-37.
De Groote, M.A, T. Testerman, Y. Xu, G. Stauffer, F.C. Fang. Homocysteine antagonsim of nitric oxide-related cytostasis in Salmonella typhimurium. Science 1996;272:414-17.
De Groote, M.A., U. A. Ochsner, M. Shiloh, C. Nathan, J. McCord, M. Dinauer, S. Libby, A. Vazquez-Torres, F. C. Fang. Periplasmic superoxide dismutase protects Salmonella from products of phagocyte NADPH-oxidase and nitric oxide synthase. Proc. Natl. Acad. Sci. U.S.A. 1997;94:13997-14001.
Croppo, G.P. Visvesvara, G.S. Leitch, G.J. Wallace, S., De Groote M.A. Western blot and immunofluorescence analysis of a human isolate of Encephalitozoon cuniculi established in culture from the urine of a patient with AIDS. J Parasitol. 1997 Feb;83(1):66-9.
Ali, S., J.C.L. Mwansa, J. Beebe, D. Heltzel, M.A. De Groote, G, Campbell. Antibiotic sensitivity and serogrouping Salmonella isolated from blood at U.T.H Lusaka, Zambia. Zambian J of Medicine and Health Sciences 1998;2:14-16.
Fang, F.C., M.A. DeGroote, J.W. Foster, A. Bäumler, U. A. Ochsner, T.Testerman, S. Bearson, J.-C. Giard, Y. Xu, G. Campbell, and T. Laessig (1999). Virulent Salmonella typhimurium has two periplasmic Cu,Zn-superoxide dismutases. Proc. Natl. Acad. Sci. USA. 1999;96:7502-7.
De Groote, M.A., R. Bjerke, H. Smith. The expanding epidemiology of Blastomycosis: Clinical features and investigation of two Colorado cases. Clinical Infectious Diseases. 2000;30(3); 582-4.
Stoekli, T., G. Mackin, and M. A. De Groote. Lumbar plexopathy due to Mycobacterium tuberculosis. Clinical Infectious Diseases. 2000;30(1) 226-7
Winstead, J.M., D. McKinsey, S. Tasker, M. A. De Groote, and L. Baddour. Meningococcal pneumonia: characterization and review of cases seen over the past 25 years. Clinical Infectious Diseases. 2000;30(1) 226-7
De Groote, M.A. Photo quiz: Broncholithiasis. Clinical Infectious Diseases. 2001;33;1427-8.
De Groote, M.A., Frank, D.N., Dowell, E., Glode, M.P., and N.R. Pace. Lactobacillus rhamnosus GG bacteremia assocaiated with probiotic use in a child with short gut syndrome. Pediatric Infectious Disease Journal 2005:24(3): 278-80.
St. Amand, A.L., Frank, D.N., De Groote, M.A., and N.R. Pace. Microscopic detection of Mycobacterium avium complex in tissue with specific rRNA Oligonucleotide Probes. J of Clinical Microbiology; 2005; 43(4) 1505-14.
De Groote, M.A. , D.N. Frank, E. Nachtway, A. St. Amand, H. Hearst, F. Garry, R. Basaraba, and N.R. Pace. Quantitative Molecular Detection and tissue distribution of Mycobacterium avium in Johne's disease. In Preparation
De Groote, M. A. and G. Huitt. Emerging Rapidly Growing Mycobacteria Infections. Invited review for Clinical Infectious Diseases. 2006:42:1756-63.
St. Amand, A.L., Frank, D.N., De Groote, M.A., and N.R. Pace. Microscopic detection of Mycobacterium tuberculosis in culture and tissue with specific rRNA Oligonucleotide Probes. J. Clin Micro 2005;43(10):5369-71.
Gardner, E. M., W.J. Burman, De Groote, M.A., G. Hildred, N. R. Pace Conventional and molecular epidemiology of macrolide resistance among new Mycobacterium avium complex isolates from HIV-infected patients. . Clin Infect Dis. 2005;41(7):1041-4.
De Groote, M.A., N.R. Pace, and J.O. Falkinham. Clonal Relationship between Mycobacterium isolates from patients with pulmonary mycobacterial infection and potting soil. Appl Environ Microbiol 2006;72:7602-6.
J.S. Kim, N. Tanaka, J.D. Newell, M.A. De Groote, K. Fulton, G. Huitt, and D. Lynch. Nontuberculous mycobacterial infections: CT scan findings, genotype and treatment response. Chest; 2005:128:3863-69.
Book Chapters
De Groote, M.A. Sexually transmitted diseases in Primary Care Secrets. Ed. J. Mladenovic. Hanley & Belfus, Inc., Philadelphia, 1995. Revised 1998.
De Groote, M.A. Fever of Unknown origin in Schrier, R.W. et al (eds) The Internal Medicine Case Book: Real patients, Real answers. pp 231-236. Boston, Lilly Brown and Company, 1994.
De Groote, M.A. Antimicrobial activity of nitric oxide in Nitric oxide in infection Ed. F.C. Fang.
De Groote, M.A. Pulmonary infection in non-HIV infected individuals. In M. avium in water. U.S. EPA/WHO publication. Editors J. Bartram and A. Dufour. E & FN Spon, London and New York. In press.
De Groote, M.A. Skin, bone, and soft tissue infections. In M. avium in water. U.S. EPA/WHO publication. Editors J. Bartram and A. Dufour. E & FN Spon, London and New York. 2004.
De Groote, M.A. Disease resulting from contaminated equipment and invasive procedures. In M. avium in water. U.S. EPA/WHO publication. Editors J. Bartram and A. Dufour. E & FN Spon, London and New York. 2004
De Groote, M. A., and Iseman, M.D. Environmental Mycobacterial Infections, in Gorbach Textbook of Infectious Diseases, 3rd edition. Sherwood Gorbach, John G. Bartlett, and Neil R. Blacklow editors. 2004