Vol. 11 | No. 4
AIDL Group Paper Gets Top Honor From the Royal Entomological Society
We are proud to announce that the paper:
MIP Faculty Conversion
Three more MIP faculty are no longer as ‘Special’ as they used to be…Congratulations to the following faculty on their conversion from 'special appointment' to 'regular appointment' tenure track positions.
MIP Special Appointment
Drs. Marcela Henao-Tamayo and Seba Mahapatra have received Special Appointment Assistant Professor positions in the MIP department. Congratulations Marcela and Seba!
Donna Willard, Assistant Manager for the Foothills Campus, has been recognized with an Everyday Hero Award by the Classified Personnel Council. Audrey Oberlin nominated Donna for her positive attitude and strong work ethic. "She epitomizes what I believe is an everyday hero. Hard working, conscientious, goal driven and completely out of the lime light. She does the best job because it is the right thing to do and no other outcome is acceptable." Congratulations Donna!
…..Look for Donna in a supporting role if we ever make that ‘Guardians of the MIP Galaxy’ movie.
How do you follow up the ‘Lousy Sex’ he gave us in 2013? Dr. Gerald Callahan has now co-authored a new textbook, Basic Veterinary Immunology, that was published by the University Press of Colorado in Boulder. The text offers a solid background in the essentials of immunology within the context of veterinary medicine. Hence it should fill a large resource gap in this important area of the veterinary curriculum. Way to go Gerry!
Dr. Chet Moore's expertise in West Nile Virus was recently featured in the Fort Colllins Coloradoan. I guess you could say that MIP definitely adds the ‘say it’ part to the ‘say it, don’t spray it’ debate…Check out the great picture of Chet and read the full article.
CSU's Proteomic and Metabolomic Facility (PMF) has earned global recognition as a "Center of Innovation"! The award comes from Waters, a global supplier of analytical laboratory instruments, in recognition of PMF’s cutting-edge analytical techniques. A key part of the recognized successes that drove this high honor is the development and implementation of something called ‘MRM-MS technology’ by MIP investigators Nicole Kruh-Garcia and Karen Dobos in collaboration with Jessica Prenni and her PMF staff. For more on this technology, also check out this issue’s MIPublication of the Month or Today@ColoradoState. Congratulations to the PMF as well as Nicole and Karen for this impressive recognition!
In the News...
MIP Professor Emeritus Ralph Smith's photograph of two baby screech owls was chosen as the "Photo of the Week" in the Fort Collins Coloradoan. Great Picture Ralph!
Detection of Mycobacterium tuberculosis peptides in the exosomes of patients with active and latent M. tuberculosis infection using MRM-MS
Nicole Kruh-Garcia, Lisa Wolfe, Lelia Chaisson, William Worodria, Payam Nahid, Jeff Schorey, J. Lucian Davis and Karen Dobos
PLoS ONE, July 2014, Volume 9, e103811
“Acid Fast” may make for a great name for an MIP road running team, but it leaves something to be desired as a diagnostic test for tuberculosis. The old ‘spit and smear’ approach is only ~50% effective in diagnosing M. tuberculosis infections. While batting .500 in baseball will get you into the Hall of Fame on the first ballot, getting it right only 50% of the time is a rather ‘2014 Rockies-esque’ performance in the game of diagnostics. Commercially available serology-based diagnostics for the disease are even worse. With almost 9 million cases of M. tb infection per year and tuberculosis second only to HIV/AIDS in human deaths caused by an infectious agent, we need to do better - Period.
MIP Publications August 2014
Veselinovic M, Yang KH, LeCureux J, Sykes C, Remling-Mulder L, Kashuba AD, Akkina R. HIV pre-exposure prophylaxis: Mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model. Virology. 2014 Aug 5;464-465C:253-263.
Eisen L, García-Rejón JE, Gómez-Carro S, Nájera Vázquez Mdel R, Keefe TJ, Beaty BJ, Loroño-Pino MA. Temporal correlations between mosquito-based dengue virus surveillance measures or indoor mosquito abundance and dengue case numbers in Mérida City, México. J Med Entomol. 2014 Jul;51(4):885-90.
Loroño-Pino MA, Chan-Dzul YN, Zapata-Gil R, Carrillo-Solís C, Uitz-Mena A, García-Rejón JE, Keefe TJ, Beaty BJ, Eisen L. Household use of insecticide consumer products in a dengue-endemic area in México. Trop Med Int Health. 2014 Jul 17. doi: 10.1111/tmi.12364.
Shi L, Ryan GJ, Bhamidi S, Troudt J, Amin A, Izzo A, Lenaerts AJ, McNeil MR, Belisle JT, Crick DC, Chatterjee D. Isolation and purification of Mycobacterium tuberculosis from H37Rv infected guinea pig lungs. Tuberculosis (Edinb). 2014 Jun 30. pii: S1472-9792(14)20479-3. doi: 10.1016/j.tube.2014.05.003
Li W, Upadhyay A, Fontes FL, North EJ, Wang Y, Crans DC, Grzegorzewicz AE, Jones V, Franzblau SG, Lee RE, Crick DC, Jackson M. Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014 Aug 18. pii: AAC.03229-14.
Kruh-Garcia NA, Wolfe LM, Chaisson LH, Worodria WO, Nahid P, Schorey JS, Davis JL, Dobos KM. Detection of Mycobacterium tuberculosis Peptides in the Exosomes of Patients with Active and Latent M. tuberculosis Infection Using MRM-MS. PLoS One. 2014 Jul 31;9(7):e103811. doi: 10.1371/journal.pone.0103811.
Sun Z, Kang Y, Norris MH, Troyer RM, Son MS, Schweizer HP, Dow SW, Hoang TT. Blocking Phosphatidylcholine Utilization in Pseudomonas aeruginosa, via Mutagenesis of Fatty Acid, Glycerol and Choline Degradation Pathways, Confirms the Importance of This Nutrient Source In Vivo. PLoS One. 2014 Jul 28;9(7):e103778. doi: 10.1371/journal.pone.0103778.
Campbell CL, Smith DR, Sanchez-Vargas I, Zhang B, Shi PY, Ebel GD. A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivo. Virology. 2014 Aug 4;464-465C:228-232. doi: 10.1016/j.virol.2014.07.009
Lozano-Fuentes S, Welsh-Rodriguez C, Monaghan AJ, Steinhoff DF, Ochoa-Martinez C, Tapia-Santos B, Hayden MH, Eisen L. Intra-annual changes in abundance of Aedes (Stegomyia) aegypti and Aedes (Ochlerotatus) epactius (Diptera: Culicidae) in high-elevation communities in Mexico. J Med Entomol. 2014 Jul;51(4):742-51.
Kobylinski KC, Alout H, Foy BD, Clements A, Adisakwattana P, Swierczewski BE, Richardson JH. Rationale for the Coadministration of Albendazole and Ivermectin to Humans for Malaria Parasite Transmission Control. Am J Trop Med Hyg. 2014 Jul 28. pii: 14-0187.
Belardinelli JM, Larrouy-Maumus G, Jones V, de Carvalho LP, McNeil MR, Jackson M. Biosynthesis and Translocation of Unsulfated Acyltrehaloses in Mycobacterium tuberculosis. J Biol Chem. 2014 Aug 14. pii: jbc.M114.581199.
Jackson M. The Mycobacterial Cell Envelope-Lipids. Cold Spring Harb Perspect Med. 2014 Aug 7. pii: a021105. doi: 10.1101/cshperspect.a021105.
De Groote MA, Gibbs S, de Moura VC, Burgess W, Richardson K, Kasperbauer S, Madinger N, Jackson M. Analysis of a panel of rapidly growing mycobacteria for resistance to aldehyde-based disinfectants. Am J Infect Control. 2014 Aug;42(8):932-4. doi: 10.1016/j.ajic.2014.05.014.
Meyer M, Freihofer P, Scherman M, Teague J, Lenaerts A, Böttger EC. In-vivo Efficacy of Apramycin in Murine Infection Models. Antimicrob Agents Chemother. 2014 Aug 18. pii: AAC.03239-14.
Moore AR, Allender MC, MacNeill AL. Effects of ranavirus infection of red-eared sliders (Trachemys scripta elegans) on plasma proteins. J Zoo Wildl Med. 2014 Jun;45(2):298-305.
Willingham K, McNulty E, Anderson K, Hayes-Klug J, Nalls A, Mathiason C. Milk collection methods for mice and reeves' muntjac deer. J Vis Exp. 2014 Jul 19;(89). doi: 10.3791/51007.
Angers R, Christiansen J, Nalls AV, Kang HE, Hunter N, Hoover E, Mathiason CK, Sheetz M, Telling GC. Structural effects of PrP polymorphisms on intra- and interspecies prion transmission. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11169-74. doi: 10.1073/pnas.1404739111. Epub 2014 Jul 17.
Weishaar KM, Edmondson EF, Thamm DH, Olver CS. Malignant mesenchymoma with widespread metastasis including bone marrow involvement in a dog. Vet Clin Pathol. 2014 Jul 30. doi: 10.1111/vcp.12180
Henao-Tamayo M, Ordway DJ, Orme IM. Memory T cell subsets in tuberculosis: What should we be targeting? Tuberculosis (Edinb). 2014 Jun 17. pii: S1472-9792(14)20474-4. doi: 10.1016/j.tube.2014.05.001.
Amsellem PM, Selmic LE, Wypij JM, Bacon NJ, Culp WT, Ehrhart NP, Powers BE, Stryhn H, Farese JP. Appendicular osteosarcoma in small-breed dogs: 51 cases (1986-2011). J Am Vet Med Assoc. 2014 Jul 15;245(2):203-10.
Root JJ, Shriner SA, Bentler KT, Gidlewski T, Mooers NL, Spraker TR, VanDalen KK, Sullivan HJ, Franklin AB. Shedding of a low pathogenic avian influenza virus in a common synanthropic mammal - the cottontail rabbit. PLoS One. 2014 Aug 11;9(8):e102513. doi: 10.1371/journal.pone.0102513.
Beatty JA, Troyer RM, Carver S, Barrs VR, Espinasse F, Conradi O, Stutzman-Rodriguez K, Chan CC, Tasker S, Lappin MR, VandeWoude S. Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats. Virology. 2014 Jul;460-461:100-7.
Please join Dr. Charlie Calisher for a discussion of his book "Lifting the Impenetrable Veil: From Yellow Fever to Ebola Hemorrhagic Fever and SARS" and get your copy signed!
Dr. Roger Jaenke, a valued member of the Pathology Department from 1969 to 1993 passed away on August 21, 2014. A memorial service and open house will be held on September 20 at 10 am at Foothills Unitarian Church, 1815 Yorktown Ave, Fort Collins, CO.
Please visit the Rocky Mountain Virology Club website for additional information and to register for the meeting.
Saturday, October 25, 2014
An ASM Distinguished Lecture will be given by Dr. Stephen Lory (Harvard Medical School) and the Keynote Address will be by Dr. Phoebe Lostroh (Colorado College). Registration is free for all students, and lunch is free for all attendees who preregister for the meeting. Student and postdoc travel and presentation awards are also available. This meeting is an excellent opportunity for students and postdocs to gain valuable presentation experience and to help build your resume. For more information and registration information, click here.
Two MIP Faculty members will be leaving this Fall. Dr. Lars Eisen has accepted a position with the CDC and Dr. Herbert Schweizer will assume the positions of Preeminence Professor in the Department of Molecular Genetics and Microbiology, College of Medicine, and Director of Emerging Pathogens Institute BSL 3 facilities at the University of Florida. Best of luck Lars and Herbert!
Thanks to the MIP Graduate Student Organization for arranging a trip to Coors Field on Thursday, August 14th to watch the Rockies play the Reds. Tickets were only $10 and carpooling and designated drivers were provided. The best part...Rockies WON!
Congratulations to MIP grad student and resident, Jennifer Malmberg for finishing 5th out of 182 in the overall female division of the Pikes Peak Marathon. You rock Jennifer!
In June Dr. Timothy Quinn Crawford, a post doc from the Akkina lab, and Dr. Aaron T. Phillips, a post doc from the Olson lab, traveled to Baltimore MD to take part in the first annual Global Virus Network (GVN) Short Course in Medical Virology. Quinn was awarded one of three Reinhard Kurth Fellowships to attend the course. They spent a week learning from some of the world's top virologist on the state of medical virology across the globe. Lectures were held at the University of MD, Johns Hopkins and the NIH, covering a wide range of topics from basic virology to vaccine development and public policy. They even visited the White House and met with officials from the Office of Science Technology and Policy.
Keri Wright from the Dobos laboratory hit the road this summer to take part in the MINI Takes the States rally (MTTS). The rally is a consumer based loyalty event that started in San Francisco on July 26 and ended in Boston on August 10. MINI owners from all over the US rally across the country stopping only to sleep and eat. Keri drove from Grand Junction, CO to Dallas, TX stopping in Albuquerque, Lubbock and Austin along the way. Check out the other photos from her trip!
Jason Cummings and Lesley Jones were part of a 12 person relay team that ran from Fort Collins to Steamboat Springs August 1-2. They finished in 31 hours and couldn't have done it without their amazing Team Captain, Kristine Bennett.
Parking Services has transitioned to virtual permits and license plate recognition technology to
enforce the parking regulations. This requires all permit holders to register the license plate of
any vehicle they may be driving to campus. You may register multiple vehicles to your permit,
but only one vehicle can park on campus at a time.
New Grant Awards
Anne Lenaerts, "Novel Spectinamide Antibiotics for the Treatment of MDR/XDR Tuberculosis", Microbiotix, Inc.
Lars Eisen, "Testing of Mosquito Pools for West Nile Virus, City of Fort Collins, 2014", City of Fort Collins
Mary Jackson, "MmpL3 as a Target for Novel Anti-TB Drugs", Potts Memorial Foundation
Ramesh Akkina, "Multi-Species Mechanisms of Drug Bio-Distribution in HIV Tissue Reservoirs", UNC-University of North Carolina
Doug Brackney, "Quantification and Purification of Large Quantities of Powassan Virus and Deer Tick Virus RNA", Battelle Memorial Institute
Doug Brackney, "Vector BioSensor: A Novel Approach for Enhancing Biological Sample Acquisition for Biosurveillance Efforts", DOD-ARMY-WRAIR
Carol Brennan "Novel Approaches for Development of Monoclonal Antibodies Against Encephalitic Alphaviruses with Enhanced Therapeutics", DOD-DTRA
Gregg Dean "Oral Induction of Mucosal and Systemic Antibodies Against HIV-1 gp41 MPER", NIH-NIAID
Mary Ann DeGroote "Optimization and Lead Selection of Novel Antimycobacterial Agents", Crestone, Inc
Mercedes Gonzalez-Juarrero "siRNA-gold Nanoparticles Host Targeted Therapy for Tuberculosis", NIH-NIAID
Angelo Izzo "Advanced Small Animal Models for the Testing of Candidate Therapeutic and Preventive", NIH-NIAID
Angelo Izzo "Testing of Mutant Mycobacteria in Established Advanced Small Animal Models",NIH-NIAID
Anne Lenaerts "Mouse Models for the Early Stage of Lead Drug Candidates against Mycobacterial Species", NIH-NIAID
Anne Lenaerts "Novel Protein Synthesis Inhibitors for the Treatment of MDR Tuberculosis", St. Jude Medical, Inc.
Karen Dobos "Mycobacterium spp. Research Reagent Replenishment ", ATCC
Ramesh Akkina "Unmasking the Latent HIV Reservoir Using Humanized Mice", AmFAR
Randall Basaraba "Therapeutic Restoration of Metabolic Homeostasis during Active TB", NIH-NIAID
Sandra Quackenbush "Molecular Biology Services for Wildlife Disease Diagnostics", Colorado Division of Parks and Wildlife
Remember to contribute any loose change to the DMIPWSFERE (Department of Microbiology Immunology and Pathology Winter Strategic Forum and Employee Recognition Event) fund. Collection receptacles can be found in Departmental offices!
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