Vol. 12 | No. 4
Dr. Carol Blair Wins Richard M. Taylor Award for Contributions to Arbovirology
We are proud to announce that Carol Blair received the prestigious Richard M. Taylor award at this year’s meeting of the American Society for Tropical Medicine and Hygiene (ASTMH) meeting. The award is named for an iconic figure in the ASTMH and recognizes outstanding contributions in the field of arbovirology throughout his or her career. Carol is the first female winner of this award. For additional information on the R.M. Taylor Award and other ASTMH awards, click here http://www.astmh.org/acav.htm
Congratulations Carol on this much deserved honor!!!
Dr. Powers receives AAVLD 2015 Distinguished Service Award
Congratulations to Barb Powers who received the American Association of Veterinary Laboratory Diagnosticians (AAVLD) 2015 Distinguished Service Award. The Distinguished service award is bestowed by AAVLD leadership to persons who have generously volunteered their time, energy and professionalism to substantially enrich and advance AAVLD and the field of diagnostic veterinary medicine. We couldn’t think of someone better to fit this description than Barb!
Ed Hoover receives the ACVP 2015 Distinguished Member Award
Congratulations to Ed Hoover who received the American College of Veterinary Pathologists 2015 Distinguished Member Award at the annual meeting in Minneapolis, MN.
(For a photo of Dr. Hoover please see the Photo Caption piece in the left hand column)
The Annual American College of Veterinary Pathologist (ACVP) Board Exam was held September 8-9th. We are pleased to announce that we have three new ACVP Diplomates in our midst:
Congrats to All!!!
Awards Galore for MIP Residents
A Rout for Rout: Emily Rout won a first place, ACVP young investigator award (poster) in the natural disease section. She has also been selected as CSU’s AKC Canine Health Foundation Clinician-Scientist Fellow for 2015.
Regan Stands Tall: Dan Regan won the 2015 Charles Louis Davis, D.V.M Foundation Student Scholarship Award.
Garcia is a ‘Keeper”: Teresa Garcia won the 2015 William Inskeep II Scholarship.
Elijah Professes Excellence: Elijah Edmondson won an ACVP/ASIP Trainee Travel Award and the Charles Capen Best Manuscript Award.
Radakovich is Rad: Lauren Radakovich won an ACVP/ASIP Trainee Travel Award
Jenn Reaches New Heights: Jenn Malmberg won an ACVP/ASIP Trainee Travel Award
Greta Krasfur wins W.D. Farr Scholarship
The National Cattlemen's Beef Foundation Board of Directors has awarded a W.D. Farr Scholarship to Anatomic Pathology Resident Greta Krafsur. W.D. Farr of Greeley, Colorado was a pioneer rancher, statesman and banker known for his extraordinary vision. His dedication to improving agriculture, livestock and water development has resulted in significant changes in farming methods that have influenced the practices of ranchers and farmers throughout the nation.
Vienna Brown wins 2015 Linda Munson Pathology Manuscript Award
We are thrilled to report that Vienna Brown has won the Linda Munson Pathology Manuscript Award for 2015 for her manuscript published in the Journal of Wildlife Diseases entitled ‘Pathogenesis and immune responses of Francisella tularensis strains in wild-caught cottontail rabbits (Sylvilagus spp.)’. The other authors on the work were Danielle Adney, Helle Bielefeldt-Ohmann, Paul Gordy, Todd Felix, Francisco Olea-Popelka and Dick Bowen (J. Wildl. Dis. 51:564-75 (July 2015)
The award is given to the best manuscript written by either a graduate student or postdoc in either the Journal of Wildlife Diseases or Journal of Zoo and Wildlife Medicine.
More on the ASTMH Meeting
Claudia Rueckert, a postdoc in the Ebel lab, was given a travel award by the American Committee on Medical Entomology to present her work on piRNA biology in mosquitoes.
MIP undergrads land three ASM Undergraduate Research Fellowships!
The American Society for Microbiology (ASM) has selected not one (which would be great), not two (which would have been special) but three (which is absolutely amazing) MIP Microbiology undergraduates as 2015 award recipients of ASM Undergraduate Research Fellowships. This fellowship is aimed at highly competitive students who wish to pursue graduate careers in microbiology and provides recipients with funds to support full time summer research in MIP and present their research results at the 2016 ASM General Meeting in Boston. Congratulations to Jasmine Donkoh, Lauren Rice and Roslyn Dermody (pictured below) on getting this very competitive award.
Undergraduate Luke Vogt wins first place poster awared at the Fall Rocky Mountain American Society for Microbiology Meeting
Luke Vogt, an undergraduate in Claudia Gentry-Weeks' lab, won first place for his poster presentation at the Fall Rocky Mountain American Society for Microbiology Meeting. His poster “Detection of Methicillin-Resistant Staphylococcus pseudintermedius in Canine Patients” was a collaborative effort with Dr. Jennifer Schlisser-Pendergraft, Ben Ouyang, Paul Morley (at the VTH) and Shay Harre (who worked on it for a year).
Reticulocyte hemoglobin content does not differentiate true from functional iron deficiency in dogs
Lauren Radakovich, Kelly Santangelo and Christine Olver
Let’s marvel for a moment about element number 26 on everyone’s favorite periodic table. Why iron is so powerful, it can even turn a man into a woman (i.e. add ‘Fe’ to male and what do you get….). Seriously though, insufficient iron causes anemia as red blood cell (RBC) numbers and internal hemoglobin content drop below normal and your cells do not get enough oxygen. A nagging problem in clinical medicine is determining the best way to get an early diagnosis of a true iron deficiency. Hemoglobin levels in blood change too slowly in response to low iron, so by the time that hemoglobin begins to diminish, clinical symptoms of iron deficiency are already in place. Instead, clinicians have turned to measuring iron in reticulocytes (young RBCs that were just released from the bone marrow) since their hemoglobin/iron stores should reflect available iron. Problem solved – right? Unfortunately things get complicated as there are two major ways to get anemic reactions. The first way is a true iron deficiency. The second scenario is that actual iron levels are normal – but your cells are unable to effectively use Fe due to inflammation or chronic illness. Cytokines and immune modulators secreted during inflammatory reactions interfere with your cells’ normal iron uptake pathways. This presumably keeps iron away from microbes to help the body fight infection – but also results in a transient ‘functional’ iron deficiency. Differentiating this ‘functional’ iron deficiency from true iron deficiency is important for proper treatments – and it’s not clear that current tests can do this.
So the question is whether or not a measurement of reticulocyte hemoglobin content is up to the task of differentiating between true iron deficiency versus iron uptake problems caused by inflammation. Well Lauren, Kelly and Christine went to find out in a study comparing 96 dogs for reticulocyte hemoglobin content as well as numerous biochemical (e.g. C reactive protein) and hematological (e.g. white blood cell counts) markers of inflammation. The data that were obtained were crystal clear – dogs with low reticulocyte hemoglobin content were much more likely than the control group to have signs of inflammation. Thus a low reticulocyte hemoglobin content does not reliably predict actual iron deficiency and a new approach is needed to provide an accurate patient diagnosis for this important health variable.
So why did we choose this study as our coveted MIPublication of the Month© for November? First of all, the study does an outstanding job substantiating a clear knowledge gap in the field of clinical pathology that will serve as a focal point for future work. A key variable in scientific success is defining an important problem – and this study does that with flying colors. Second, we’re dying to find out the group’s ideas for how to more effectively distinguish between the causes of iron deficiency in dogs, as this sounds like a great topic to brainstorm over a few beers. Finally, we were just plain curious as to why ‘reticulocyte hemoglobin content’ is abbreviated backwards (CHr) – and are sure glad that the Social Security Administration didn’t adopt similar logic when coming up with an acronym for its name….
Best wishes to all for a fantastic Fall Break.
MIP Publications Novemeber 2015
MIPublications for the November 2015 newsletter
Gasbarre LC, Ballweber LR, Stromberg BE, Dargatz DA, Rodriguez JM, Kopral CA, Zarlenga DS. Effectiveness of current anthelmintic treatment programs on reducing fecal egg counts in United States cow-calf operations. Can J Vet Res. 2015 Oct;79(4):296-302.
Stromberg BE, Gasbarre LC, Ballweber LR, Dargatz DA, Rodriguez JM, Kopral CA, Zarlenga DS. Prevalence of internal parasites in beef cows in the United States: Results of the National Animal Health Monitoring System's (NAHMS) beef study, 2007-2008. Can J Vet Res. 2015 Oct;79(4):290-5.
Seaman JA, Alout H, Meyers JI, Stenglein MD, Dabiré RK, Lozano-Fuentes S, Burton TA, Kuklinski WS, Black WC 4th, Foy BD. Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals. BMC Genomics. 2015 Oct 15;16(1):797. doi: 10.1186/s12864-015-2029-8.
Upadhyay A, Fontes FL, Gonzalez-Juarrero M, McNeil MR, Crans DC, Jackson M, Crick DC. Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ. ACS Cent Sci. 2015 Sep 23;1(6):292-302.
Bleakley S, Duncan CG, Monnet E. Thoracoscopic Lung Lobectomy for Primary Lung Tumors in 13 Dogs. Vet Surg. 2015 Oct 17. doi: 10.1111/vsu.12411. [Epub ahead of print]
Radakovich LB, Santangelo KS, Olver CS. Reticulocyte hemoglobin content does not differentiate true from functional iron deficiency in dogs. Vet Clin Pathol. 2015 Oct 5. doi: 10.1111/vcp.12294. [Epub ahead of print]
Chiu E, Troyer RM, Lappin MR, VandeWoude S. Bovine herpesvirus 4 DNA is not detected in free-ranging domestic cats from California, Colorado or Florida. J Feline Med Surg. 2015 Oct 8. pii: 1098612X15607586. [Epub ahead of print]
Zabel MD, Reid C. A brief history of prions. Pathog Dis. 2015 Oct 7. pii: ftv087. [Epub ahead of print]
MSO Fundraiser: Buy a Beautiful 2016 Calendar
The Microbiology Student Organization is working with retired faculty member Ralph Smith to raise funds for the Organization. A 2016 calendar comprised of photographs from locations within one day's drive of Fort Collins is currently being offered for sale at the front desk of the Microbiology and Pathology Building. A display copy of the calendar is available at each location, plus a sign-up sheet for those wanting to purchase calendars for themselves, family and friends. For every calendar sold, MSA will receive $5.
(**microbiology office staff not included with purchase)
There was a sighting of Miss Colorado in the MIP department on Halloween, along with several others! Click the link below to see more pictures.
We are thrilled to announce that MIP Virology Faculty will be hosting the 39th Annual Meeting of the American Society for Virology here at CSU June 13-17, 2020. This is one of the premier and largest annual gatherings of virologists (there were ~1400 attendees from 40 different countries at the ASV meeting held here in 2014). Mark your calendars!!!!
MIP Adopt-a-Family giving trees will appear in MIP front offices this week with tags for 9 children aged from 2 weeks to 10yrs old. Please consider taking a tag and purchasing a gift (or gift card) for a needy child this Holiday Season. Gifts are due back in MIP offices (Pathology, Microbiology, AIDL) by November 30. If you have questions, or would like to help deliver gifts to the Salvation Army on Dec 1, please contact Carol Wilusz.
When: Friday, December 4th
Where: Lory Student Center, Ballroom Rm 350,
Time: 5:00-10:00 pm, band starts at 7:00 pm
Bring your dancing shoes!
All faculty, staff and their families are invited and encouraged to attend. Dinner will be catered at the Lory Student Center and a band, the Absolutes, will provide a mix of rock, soul and blues after dinner. A cash bar will also be open during the event.
This year’s event will also include a guest magician, Dr. Tim Holt for a dazzling magic show – please be sure to bring your children.
The event requires self-funding to support the associated costs. The per head estimate is $25 for adults and $6 for children.
MS-B Students by Day, Trivia Champs at Night
Students from the MS-B program recently got together at Fuzzy’s Taco Shop...and came out the winners of the Trivia Contest!
AIDL versus Cheesehead Mosquitoes
James Weger, a postdoc in Greg Ebel’s lab, ventured out to Northern Wisconsin to work with an industry partner (wearing green) to develop a tick trap. In this photo they are setting their gizmos up for a field trial.
An Afternoon Of Cleaning in the Belisle Lab
The big bags of trash and recycling tub are a true testimony of an afternoon dedicated to cleaning and organizing the lab. The substantial amount of calories (pizza, golden tacos and sweets) eaten during lunch, plus a coffee break probably had something to do with the effectiveness of this project!
In The News...
Dr. Foy was featured in a BBC article: Nobel-winning drug 'tackles malaria. See the article here:
Proof that working in the Wilusz Lab is not good for you?
This week there was an internet death hoax regarding pianist Dr. John (Anderson). Who can forget (Phillida) Charley’s Angels? This Spring, the Wilusz Lab hired a new postdoctoral fellow named Joe Russo. On December 19th, this band will be playing at the Fillmore in Denver:
Nicole Garneau (Ph.D. Wilusz Lab 2010) and her husband Stewart Swan welcomed their first child, Georgia Leo Swan, on Aug 20, 2015. She was 7lb 1oz and 20 inches long. Mom and baby are healthy and happy!
Ashley Neff (Ph.D. 2012, Wilusz Lab) and her husband Michael welcomed their baby boy Wyatt Lee Neff on September 20th, 2015. He was born via C-section and weighed in at 7lb 10oz. All are doing well!
Overview of the new MIP Undergraduate Research Opportunities Program for Microbiology Undergraduate Students
To enhance the value of the Microbiology Undergraduate Major, we have recently established a research training program for microbiology undergraduate students that will begin Spring 2016. Ten microbiology majors will be provided the opportunity to conduct research under the mentorship of MIP faculty.
Interested? Here are some of the specifics:
Baby it's getting' cold oustide...
When snow or ice blanket the Northern Colorado landscape, there are several places you can find information on campus delays or closures:
If there is a campus closure due to weather, the university appreciates that ALL faculty, staff and students go home and remain off-campus to allow for Facilities crews to effectively address all campus-associated weather hazards.
"The man who complains about the way the ball bounces is likely the one who dropped it."
Choose your Caption
Some of the attendees at a ‘Talk Like a Pirate Day’ party hosted by Candace Mathiason
1. Photographic proof that ‘PRC’ really stands for Pirate Rehab Clinic, not Prion Research Center
2.So that’s why Assoc. Dean Vandewoude has been ending all of her sentences with ‘…me Hearties’ over the last month
3.Don’t be surprised if the adjective ‘swashbuckling’ is used in a future prion research paper
4.Ed has had that same look on his face since the NLCS series ended against the Mets………
Rebecca Timmons, who graduated from our Micro Undergraduate Program and is now attending CSU vet school, published a novel this summer entitled, “The Story of Jess...And Her Dead Uncle's Undead Girlfriend”.
Click on the picture above for more information on the book.
Anyone have any creative ideas regarding parasite therapeutics? Check out the new RFA entitled ‘Discovery/Development of Novel Therapeutics for Eukaryotic Pathogens (R21/R33)’ at http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-054.html
...or creative ideas regarding immune reactions associated with mycobacteria infections?Check out the new RFA entitled ‘Characterization of Mycobacterial Induced Immunity in HIV-infected and Uninfected Individuals (R21)’ at http://grants.nih.gov/grants/guide/pa-files/PAR-15-360.html
NIAID paylines while the federal budget is in continuing resolution. NIAID has set interim R01 paylines at the 10 percentile for regular PIs and the 14 percentile for new PIs
New Grant Awards
Anne Lenaerts, "TB Drug Accelerator: TB Mouse in vivo Models - Planning Grant", Gates Foundation.
Susan Vande Woude, "Anticoagulant Rodenticide Exposure and Immune System Function", USDA-APHIS-Animal Plant Health Insp Srvc.
Ashley McGrew, " Advancements in Marine Parasitology: Optimization and Comparison of Diagnostic Techniques, Survey of Common Practices, and Development of Educational", National Center for Veterinary Parasitol.
Bradley Borlee, "Burkholderia Pseudomallei Library Copy Preparation", American Type Culture Collection.
Brian Foy, "New Approaches for Addressing Outdoor/Residual Malaria Transmission", Gates Foundation .
Candace Mathiason, "Sterilization and Disposal of Agricultural Quarantine Waste", USDA-APHIS-Animal Plant Health Insp Srvc.
Martha Mehaffy, "DNA Isolation from Sputum Sediment", Aeras.
Mary DeGroote, "Optimization and Lead Selection of Novel Antimycobacterial Agents", Crestone, Inc.
Mary Jackson, "Optimization and Lead Selection of Novel Antimycobacterial Agents", Crestone, Inc.
Mary Jackson (Primary PI)-1682;
Mercedes Gonzalez-Juarrero, "Effect of TLR-2 and CD14 Gene Silencing in Mycobacterium Tuberculosis Infection", Universidad Autonoma de Nuevo Leon.
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