Vol. 11 | No. 3
Congratulations to Dr. Ed Hoover for being elected to the prestigious National Academy of Sciences. The Academy was established under a congressional charter signed by President Abraham Lincoln in 1863 and is a private, nonprofit institution which recognizes distinguished and continuing achievements in original research. Dr. Hoover is one of 84 newly elected members and one of 9 CSU faculty members elected to the Academy. Read the full story at Today @ Colorado State. Nicely done Ed!
Congratulations to the following faculty on their upcoming promotion and/or tenure actions which became effective July 1, 2014:
Associate Director of RICRO
Dr. Gary Mason was recently awarded the Zoetis Distinguished Veterinary Teacher Award. This award is given to educators in recognition of their character and leadership qualities as well as their outstanding teaching abilities. Congratulations Gary!
Dr. Alan Schenkel has been promoted to Associate Editor at the Journal of Immunology. Way to go Alan!
On April 22, Becky Trentlage, MIPs Business Officer, was recognized and presented with the first overall CVMBS Living our Values award, which focuses on Transparency, Accountability, Collaboration, and Team. Becky's nominator had this to say: Becky is actively pursuing the implementation of the College’s shared values. She looks at the impacts of decisions on all members of the departmental team, research teams, and academic teams. She has the ability to see the short-term impacts and long-term visions. She strives daily to bring her team together to maximize efficiencies and effectiveness. She recognizes that strong teams are built on individual efforts and recognition of effort, no matter how small.Well done Becky!
Congratulations to the following students who will be completing their Veterinary Residency Program this year:
A reception was held on June 10th to congratulate each resident on their service committment to CSU Pathology. View the photo gallery from the reception.
Sarah Nelson, an MIP student was recently featured in her hometown paper, Hot Springs Star. Sarah has been selected to participate in the "Doctor Interns" program, a non-profit organization that takes students on a two week internship to Shree Prannath Hospital in Surat, India. While there, Sarah will have the opportunity to rotate among a team of five doctors with different specialites. Congratulations Sarah!
Phi Kappa Phi Outstanding Junior Award
Dr. Mark Stenglein signs on the
We are pleased to announce that Dr. Mark Stenglein will be joining MIP September 1 as an Assistant Professor in the new Computational Biologist position that was recently created. Welcome aboard Mark!
Outstanding Specialty Resident Award
Greta Krafsur, a resident in the Anatomic Pathology Program, recently received the Outstanding Specialty Resident award. This award is given for invaluable teaching and clinical support of CSU Veterinary students. Way to go Greta!
2014 CURC Symposium
The annual Celebrate Undergraduate Research and Creativity (CURC) Symposium was held on April 15th in Johnson Hall. Several MIP students participated and won awards in this years event.
MIP Winners of the 2014 CURC Symposium:
Check out the CURC Photo Gallery.
Congratulations Micro BS Program Graduates
Congratulations to the first class of Micro MS-B Program Graduates
A hearty congratulations to MIP labs for producing a whopping 73 manuscripts that appeared on Pub Med between February and June of this year! With so many great papers out there in the literature, how can we highlight just one in this belated MIPnews issue? Thus here’s a brief description of four noteworthy papers that appeared this Spring. Frankly we wish there was space to highlight at least half a dozen more……
Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia®) in canine mast cell tumor.
Halsey CH, Gustafson DL, Rose BJ, Wolf-Ringwall A, Burnett RC, Duval DL, Avery AC, Thamm DH.
BMC Vet Res. doi: 10.1186/1746-6148-10-105.
When you are trying to understand and eventually cure dog mast cell tumors – the most common neoplasms in the canine planet – your toolbox can never be big enough. Drugs that target the Kit tyrosine kinase have been approved to treat these tumors, but the development of resistance in the tumor cells being treated is a common problem that ultimately leads to adverse clinical outcomes. In this collaborative study, MIP and CS researchers have developed a mast cell tumor line that mimics a drug-resistant mast cell tumor. This novel reagent should help researchers not only understand drug resistance mechanisms, but also may serve as a tool in the investigation of ways to treat KIT inhibitor-resistant tumors in our furry friends.
A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis.
Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA.
PLoS One, 9(4):e93953
This paper provides on the latest update on the use of trisubstituted benzimidazoles as a platform to develop a novel class of drugs to combat M. tuberculosis infections. By exploiting structure-activity relationships, Ric and the gang have come up with a new lead compound that can reduce mycobacterial replication in the lungs. In other words, the Mtb infected mice in the study breathed a ‘sigh of relief’ – and hopefully this and/or related compounds will continue to perform well along the many steps in the drug development pipeline.
Quinacrine promotes replication and conformational mutation of chronic wasting disease prions.
Bian J, Kang HE, Telling GC.
Proc Natl Acad Sci U S A., 111:6028-33
Developing drugs to treat prion diseases has been a frustrating experience to say the least. The drug quinacrine was in clinical development for the better part of a decade before it was determined that it simply didn’t work as advertised. In this study, Glenn and the lab closely examined the effect of this drug on prions and found that quinacrine appears to force the prion protein into a specific conformation that can actually increase the multiplication rate for certain prion agents/strains rather than reduce it. This observation provides extremely valuable information to instruct how anti-prion drugs should be screened. Since prion drug discovery, like much of laboratory science, is only as good/successful as the quality of the assay used in the experiment, the results in this study may be a very powerful wake up call.
The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production.
Chapman EG, Costantino DA, Rabe JL, Moon SL, Wilusz J, Nix JC, Kieft JS.
In this collaborative study that grew out of interactions at a meeting of the Rocky Mountain Virology Club in Pingree Park, the Kieft lab has solved a very unique structure in the flavivirus genomic RNA that blocks and ultimately represses a major exonuclease involved in cellular mRNA decay. The repression of this enzyme by the RNA structure stabilizes viral RNA and significantly dysregulates cellular gene expression which may contribute to viral-induced cytopathology. This fascinating knot-like structure (which made the cover of the 2014 RNA Society Meeting abstract book) is a very attractive drug target and opens the door for a detailed molecular understanding of an understudied area of virus-host interaction.
MIP Publications May 2014
Soffler C, Bosco-Lauth AM, Aboellail TA, Marolf AJ, Bowen RA. Pathogenesis of percutaneous infection of goats with Burkholderia pseudomallei: clinical, pathologic, and immunological responses in chronic melioidosis. Int J Exp Pathol. 2014 Apr;95(2):101-19. doi: 10.1111/iep.12068.
Engel S, Randall EK, Cuddon PA, Webb BT, Aboellail TA. Imaging diagnosis: Multiple cartilaginous exostoses and calcinosis circumscripta occurring simultaneously in the cervical spine of a dog. Vet Radiol Ultrasound. 2014 May-Jun;55(3):305-9. doi: 10.1111/vru.12066. Epub 2013 Jun 14.
Halsey CH, Gustafson DL, Rose BJ, Wolf-Ringwall A, Burnett RC, Duval DL, Avery AC, Thamm DH. Development of an in vitro model of acquired resistance to toceranib phosphate (Palladia®) in canine mast cell tumor. BMC Vet Res. 2014 May 6;10(1):105. doi: 10.1186/1746-6148-10-105.
Seelig DM, Avery P, Webb T, Yoshimoto J, Bromberek J, Ehrhart EJ, Avery AC. Canine T-zone lymphoma: unique immunophenotypic features, outcome, and population characteristics. J Vet Intern Med. 2014 May;28(3):878-86.
Ballweber LR, Beugnet F, Marchiondo AA, Payne PA. American Association of Veterinary Parasitologists' review of veterinary fecal flotation methods and factors influencing their accuracy and use-Is there really one best technique? Vet Parasitol. 2014 May 17. pii: S0304-4017(14)00288-X. doi: 10.1016/j.vetpar.2014.05.009.
Lishnevsky M, Young LC, Woods SJ, Groshong SD, Basaraba RJ, Gilchrist JM, Higgins DM, Gonzalez-Juarrero M, Bass TA, Muller WA, Schenkel AR. Microhemorrhage is an early event in the pulmonary fibrotic disease of PECAM-1 deficient FVB/n mice. Exp Mol Pathol. 2014 Jun 24. pii: S0014-4800(14)00092-6. doi: 10.1016/j.yexmp.2014.06.008.
Bartek IL, Woolhiser LK, Baughn AD, Basaraba RJ, Jacobs WR Jr, Lenaerts AJ, Voskuil MI. Mycobacterium tuberculosis Lsr2 is a global transcriptional regulator required for adaptation to changing oxygen levels and virulence. MBio. 2014 Jun 3;5(3):e01106-14. doi: 10.1128/mBio.01106-14.
Shikani AH, Sidhaye VK, Basaraba RJ, Shikani HJ, Alqudah MA, Kirk N, Cope E, Leid JG. Mucosal expression of aquaporin 5 and epithelial barrier proteins in chronic rhinosinusitis with and without nasal polyps. Am J Otolaryngol. 2014 May-Jun;35(3):377-83. doi: 10.1016/j.amjoto.2013.11.011.
Ackart DF, Hascall-Dove L, Caceres SM, Kirk NM, Podell BK, Melander C, Orme IM, Leid JG, Nick JA, Basaraba RJ. Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis. Pathog Dis. 2014 Apr;70(3):359-69. doi: 10.1111/2049-632X.12144.
Baak-Baak CM, Arana-Guardia R, Cigarroa-Toledo N, Loroño-Pino MA, Reyes-Solis G, Machain-Williams C, Beaty BJ, Eisen L, García-Rejón JE. Vacant lots: productive sites for Aedes (Stegomyia) aegypti (Diptera: Culicidae) in Mérida City, México. J Med Entomol. 2014 Mar;51(2):475-83.
Arana-Guardia R, Baak-Baak CM, Loroño-Pino MA, Machain-Williams C, Beaty BJ, Eisen L, García-Rejón JE. Stormwater drains and catch basins as sources for production of Aedes aegypti and Culex quinquefasciatus. Acta Trop. 2014 Jun;134:33-42.
Porta J, Jose J, Roehrig JT, Blair CD, Kuhn RJ, Rossmann MG. Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies. J Virol. 2014 Jun 11. pii: JVI.01286-14.
Chotiwan N, Roehrig JT, Schlesinger JJ, Blair CD, Huang CY. Molecular determinants of dengue virus 2 envelope protein important for virus entry in FcγRIIA-mediated antibody-dependent enhancement of infection. Virology. 2014 May;456-457:238-46. doi: 10.1016/j.virol.2014.03.031.
Skalsky RL, Olson KE, Blair CD, Garcia-Blanco MA, Cullen BR. A "microRNA-like" small RNA expressed by Dengue virus? Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2359. doi: 10.1073/pnas.1406854111.
Shearin H, Bessen RA. Axonal and transynaptic spread of prions. J Virol. 2014 May 21. pii: JVI.00378-14.
Lopez B, Ponce G, Gonzalez JA, Gutierrez SM, Villanueva OK, Gonzalez G, Bobadilla C, Rodriguez IP, Black WC 4th, Flores AE. Susceptibility to chlorpyrifos in pyrethroid-resistant populations of Aedes aegypti (Diptera: Culicidae) from Mexico. J Med Entomol. 2014 May;51(3):644-9.
Schountz T, Quackenbush S, Rovnak J, Haddock E, Black WC 4th, Feldmann H, Prescott J. Differential Lymphocyte and Antibody Responses in Deer Mice Infected with Sin Nombre or Andes Hantaviruses. J Virol. 2014 May 14. pii: JVI.00004-14.
Franz AW, Sanchez-Vargas I, Raban RR, Black WC 4th, James AA, Olson KE. Fitness impact and stability of a transgene conferring resistance to dengue-2 virus following introgression into a genetically diverse Aedes aegypti strain. PLoS Negl Trop Dis. 2014 May 8;8(5):e2833. doi: 10.1371/journal.pntd.0002833.
Brandt LE, Ehrhart EJ, Scherman H, Olver CS, Bohn AA, Prenni JE. Characterization of the canine urinary proteome. Vet Clin Pathol. 2014 Apr 28. doi: 10.1111/vcp.12147. [Epub ahead of print]
Emanuelli MP, Bohn AA. What is your diagnosis? Dermal mass in a dog. Vet Clin Pathol. 2014 Mar 3. doi: 10.1111/vcp.12130. [Epub ahead of print]
Rivoire BL, Groathouse NA, TerLouw S, Neupane KD, Ranjit C, Sapkota BR, Khadge S, Kunwar CB, Macdonald M, Hawksworth R, Thapa MB, Hagge DA, Tibbals M, Smith C, Dube T, She D, Wolff M, Zhou E, Makhene M, Mason R, Sizemore C, Brennan PJ. Safety and efficacy assessment of two new leprosy skin test antigens: randomized double blind clinical study. PLoS Negl Trop Dis. 2014 May 29;8(5):e2811. doi: 10.1371/journal.pntd.0002811
Rivoire BL, TerLouw S, Groathouse NA, Brennan PJ. The Challenge of Producing Skin Test Antigens with Minimal Resources Suitable for Human Application against a Neglected Tropical Disease; Leprosy. PLoS Negl Trop Dis. 2014 May 29;8(5):e2791. doi: 10.1371/journal.pntd.0002791.
Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E. Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases. J Med Chem. 2014 Apr 1. [Epub ahead of print]
Perley CC, Frahm M, Click EM, Dobos KM, Ferrari G, Stout JE, Frothingham R. The Human Antibody Response to the Surface of Mycobacterium tuberculosis. PLoS One. 2014 Jun 11;9(2):e98938. doi: 10.1371/journal.pone.0098938.
Duncan CG, Tiller R, Mathis D, Stoddard R, Kersh GJ, Dickerson B, Gelatt T. Brucella placentitis and seroprevalence in northern fur seals (Callorhinus ursinus) of the Pribilof Islands, Alaska. J Vet Diagn Invest. 2014 May 6.
McLeland SM, Lunn KF, Duncan CG, Refsal KR, Quimby JM. Relationship among Serum Creatinine, Serum Gastrin, Calcium-phosphorus Product, and Uremic Gastropathy in Cats with Chronic Kidney Disease. J Vet Intern Med. 2014 May;28(3):827-37.
Flynn P, Duncan CG, Palmer RH, Duerr FM. In Vitro Incidence of Fibular Penetration With and Without the Use of a Jig During Tibial Plateau Leveling Osteotomy. Vet Surg. 2014 Mar 11. doi: 10.1111/j.1532-950X.2014.12152.x. [Epub ahead of print]
Wieczorek AE, Troudt JL, Knabenbauer P, Taylor J, Pavlicek RL, Karls R, Hess A, Davidson RM, Strong M, Bielefeldt-Ohmann H, Izzo AA, Dobos KM. HspX vaccination and role in virulence in the guinea pig model of tuberculosis. Pathog Dis. 2014 Feb 24. doi: 10.1111/2049-632X.12147. [Epub ahead of print]
Ebel GD. Toward an activist agenda for monitoring virus emergence. Cell Host Microbe. 2014 Jun 11;15(6):655-6. doi: 10.1016/j.chom.2014.05.014.
Eisen L, Monaghan AJ, Lozano-Fuentes S, Steinhoff DF, Hayden MH, Bieringer PE. The impact of temperature on the bionomics of Aedes (Stegomyia) aegypti, with special reference to the cool geographic range margins. J Med Entomol. 2014 May;51(3):496-516.
Shoeneman JK, Ehrhart EJ 3rd, Charles JB, Thamm DH. Survivin inhibition via EZN-3042 in canine lymphoma and osteosarcoma. Vet Comp Oncol. 2014 Jun 13. doi: 10.1111/vco.12104.
Edmondson EF, Bright JM, Halsey CH, Ehrhart EJ. Pathologic and Cardiovascular Characterization of Pheochromocytoma-Associated Cardiomyopathy in Dogs. Vet Pathol. 2014 May 8.
Paoloni M, Webb C, Mazcko C, Cherba D, Hendricks W, Lana S, Ehrhart EJ, Charles B, Fehling H, Kumar L, Vail D, Henson M, Childress M, Kitchell B, Kingsley C, Kim S, Neff M, Davis B, Khanna C, Trent J. Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials. PLoS One. 2014 Mar 17;9(3):e90028. doi: 10.1371/journal.pone.0090028.
Halsey CH, Worley DR, Curran K, Charles JB, Ehrhart EJ. The use of novel lymphatic endothelial cell-specific immunohistochemical markers to differentiate cutaneous angiosarcomas in dogs. Vet Comp Oncol. 2014 Mar 5. doi: 10.1111/vco.12088. [Epub ahead of print]
Gadomski BC, McGilvray KC, Easley JT, Palmer RH, Ehrhart EJ, Haussler KK, Browning RC, Santoni BG, Puttlitz CM. An in vivo ovine model of bone tissue alterations in simulated microgravity conditions. J Biomech Eng. 2014 Feb;136(2):021020. doi: 10.1115/1.4025854.
Haley NJ, Carver S, Hoon-Hanks L, Henderson DM, Davenport KA, Bunting E, Gray S, Trindle B, Galeota J, LeVan I, Dubovos T, Shelton P, Hoover EA. Chronic wasting disease detection in the lymph nodes of free-ranging cervids by real time quaking-induced conversion. J Clin Microbiol. 2014 Jun 23. pii: JCM.01258-14.
Schurich JA, Kumar S, Eisen L, Moore CG. Modeling Culex tarsalis abundance on the northern Colorado front range using a landscape-level approach. J Am Mosq Control Assoc. 2014 Mar;30(1):7-20.
Springer YP, Eisen L, Beati L, James AM, Eisen RJ. Spatial distribution of counties in the continental United States with records of occurrence of Amblyomma americanum (Ixodida: Ixodidae). J Med Entomol. 2014 Mar;51(2):342-51.
Slade JR, Mulligan RT, Labrecque B, Kobylinski KC, Gray M, Kuklinski WS, Burton TA, Seaman JA, Sylla M, Foy BD. Design and testing of a novel, protective human-baited tent trap for the collection of anthropophilic disease vectors. J Med Entomol. 2014 Jan;51(1):253-63.
Seelig DM, Nalls AV, Flasik M, Frank V, Eaton S, Mathiason CK, Hoover EA. Lesion Profiling and Subcellular Prion Localization of Cervid Chronic Wasting Disease in Domestic Cats. Vet Pathol. 2014 Feb 27. [Epub ahead of print]
Torres-Henderson C, Hesser J, Hyatt DR, Hawley J, Brewer M, Lappin MR. Pilot study to evaluate the role of Mycoplasma species in cat bite abscesses. J Feline Med Surg. 2014 Mar 18. [Epub ahead of print]
Yang L, Lu S, Belardinelli J, Huc-Claustre E, Jones V, Jackson M, Zgurskaya HI. RND transporters protect Corynebacterium glutamicum from antibiotics by assembling the outer membrane. Microbiologyopen. 2014 Jun 18. doi: 10.1002/mbo3.182.
Angala SK, Belardinelli JM, Huc-Claustre E, Wheat WH, Jackson M. The cell envelope glycoconjugates of Mycobacterium tuberculosis. Crit Rev Biochem Mol Biol. 2014 Jun 10:1-39.
Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS Pathog. 2014 May 22;10(5):e1004144. doi: 10.1371/journal.ppat.1004144.
Svetlíková Z, Baráth P, Jackson M, Korduláková J, Mikušová K. Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid - Monoacylated phosphatidylinositol dimannoside. Protein Expr Purif. 2014 Aug;100:33-9. doi: 10.1016/j.pep.2014.04.014.
Burgess BA, Noyes NR, Bolte DS, Hyatt DR, van Metre DC, Morley PS. Rapid Salmonella detection in experimentally inoculated equine faecal and veterinary hospital environmental samples using commercially available lateral flow immunoassays. Equine Vet J. 2014 Feb 9. doi: 10.1111/evj.12234. [Epub ahead of print]
Calado Nogueira de Moura V, Gibbs S, Jackson M. Gene Replacement in Mycobacterium chelonae: Application to the Construction of Porin Knock-Out Mutants. PLoS One. 2014 Apr 16;9(4):e94951. doi: 10.1371/journal.pone.0094951.
Tettelin H, Davidson RM, Agrawal S, Aitken ML, Shallom S, Hasan NA, Strong M, de Moura VC, De Groote MA, Duarte RS, Hine E, Parankush S, Su Q, Daugherty SC, Fraser CM, Brown-Elliott BA, Wallace RJ Jr, Holland SM, Sampaio EP, Olivier KN, Jackson M, Zelazny AM. High-level relatedness among Mycobacterium abscessus subsp. massiliense strains from widely separated outbreaks. Emerg Infect Dis. 2014 Mar;20(3):364-71.
Irwin SM, Gruppo V, Brooks E, Gilliland J, Scherman M, Reichlen MJ, Leistikow R, Kramnik I, Nuermberger EL, Voskuil MI, Lenaerts AJ. Limited Activity of Clofazimine as a Single Drug in a Mouse Model of Tuberculosis Exhibiting Caseous Necrotic Granulomas. Antimicrob Agents Chemother. 2014 Jul;58(7):4026-4034.
Rice AD, Adams MM, Lindsey SF, Swetnam DM, Manning BR, Smith AJ, Burrage AM, Wallace G, MacNeill AL, Moyer RW. Protective Properties of Vaccinia Virus-Based Vaccines: Skin Scarification Promotes a Nonspecific Immune Response That Protects against Orthopoxvirus Disease. J Virol. 2014 Jul 15;88(14):7753-63. doi: 10.1128/JVI.00185-14.
Nathaniel R, MacNeill AL, Wang YX, Turner PC, Moyer RW. Cowpox virus CrmA, Myxoma virus SERP2 and baculovirus P35 are not functionally interchangeable caspase inhibitors in poxvirus infections. J Gen Virol. 2004 May;85(Pt 5):1267-78.
Shinoda H, Legare ME, Mason GL, Berkbigler JL, Afzali MF, Flint AF, Hanneman WH. Significance of ERα, HER2, and CAV1 expression and molecular subtype classification to canine mammary gland tumor. J Vet Diagn Invest. 2014 Apr 23. [Epub ahead of print]
Rout ED, Webb TL, Laurence HM, Long L, Olver CS. Transferrin receptor expression in serum exosomes as a marker of regenerative anaemia in the horse. Equine Vet J. 2014 Feb 12. doi: 10.1111/evj.12235. [Epub ahead of print]
Orme IM, Ordway DJ. The host response to non-tuberculous mycobacterial infections of current clinical importance. Infect Immun. 2014 Jun 9. pii: IAI.01606-13.
Scotch M, Lam TT, Pabilonia KL, Anderson T, Baroch J, Kohler D, DeLiberto TJ. Diffusion of influenza viruses among migratory birds with a focus on the Southwest United States. Infect Genet Evol. 2014 Jun 6;26C:185-193. doi: 10.1016/j.meegid.2014.05.029.
Edmondson EF, Hess AM, Powers BE. Prognostic Significance of Histologic Features in Canine Renal Cell Carcinomas: 70 Nephrectomies. Vet Pathol. 2014 May 14. pii: 0300985814533803.
Santangelo KS, Kaeding AC, Baker SA, Bertone AL. Quantitative Gait Analysis Detects Significant Differences in Movement between Osteoarthritic and Nonosteoarthritic Guinea Pig Strains before and after Treatment with Flunixin Meglumine. Arthritis. 2014;2014:503519. doi: 10.1155/2014/503519.
Knudson SE, Kumar K, Awasthi D, Ojima I, Slayden RA. In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis. Tuberculosis (Edinb). 2014 Apr 1. pii: S1472-9792(14)20389-1. doi: 10.1016/j.tube.2014.03.007. [Epub ahead of print]
Schiebel J, Chang A, Shah S, Lu Y, Liu L, Pan P, Hirschbeck MW, Tareilus M, Eltschkner S, Yu W, Cummings JE, Knudson SE, Bommineni GR, Walker SG, Slayden RA, Sotriffer CA, Tonge PJ, Kisker C. Rational Design of Broad-Spectrum Antibacterial Activity based on a Clinically Relevant Enoyl-ACP Reductase Inhibitor. J Biol Chem. 2014 Apr 16. [Epub ahead of print]
Knudson SE, Awasthi D, Kumar K, Carreau A, Goullieux L, Lagrange S, Vermet H, Ojima I, Slayden RA. A Trisubstituted Benzimidazole Cell Division Inhibitor with Efficacy against Mycobacterium tuberculosis. PLoS One. 2014 Apr 15;9(4):e93953. doi: 10.1371/journal.pone.0093953.
Park B, Awasthi D, Chowdhury SR, Melief EH, Kumar K, Knudson SE, Slayden RA, Ojima I. Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents. Bioorg Med Chem. 2014 May 1;22(9):2602-12.
Pan P, Knudson SE, Bommineni GR, Li HJ, Lai CT, Liu N, Garcia-Diaz M, Simmerling C, Patil SS, Slayden RA, Tonge PJ. Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy. ChemMedChem. 2014 Apr;9(4):776-91.
Schweizer HP, Limmathurotsakul D, Peacock SJ. New insights from the 7th world melioidosis congress 2013. Emerg Infect Dis. 2014 Jul;20(7). doi: 10.3201/eid2007.131737.
Delaney MA, Colegrove KM, Spraker TR, Zuerner RL, Galloway RL, Gulland FM. Isolation of Leptospira from a Phocid: Acute Renal Failure and Mortality from Leptospirosis in Rehabilitated Northern Elephant Seals (Mirounga angustirostris), California, USA. J Wildl Dis. 2014 May 7.
Spraker TR, Lyons ET, Kuzmina TA, Tift MS, Raverty S, Jaggi N, Crocker DE. Causes of death in preweaned northern elephant seal pups (Mirounga angustirostris, Gill, 1866), Ano Nuevo State Reserve, California, 2012. J Vet Diagn Invest. 2014 Mar;26(2):320-6.
Cautivo K, Schountz T, Acuña-Retamar M, Ferrés M, Torres-Pérez F. Rapid enzyme-linked immunosorbent assay for the detection of hantavirus-specific antibodies in divergent small mammals. Viruses. 2014 May 6;6(5):2028-37. doi: 10.3390/v6052028.
Schountz T, Prescott J. Hantavirus immunology of rodent reservoirs: current status and future directions. Viruses. 2014 Mar 14;6(3):1317-35.
Bobosha K, Tjon Kon Fat EM, van den Eeden SJ, Bekele Y, van der Ploeg-van Schip JJ, de Dood CJ, Dijkman K, Franken KL, Wilson L, Aseffa A, Spencer JS, Ottenhoff TH, Corstjens PL, Geluk A. Field-evaluation of a new lateral flow assay for detection of cellular and humoral immunity against Mycobacterium leprae. PLoS Negl Trop Dis. 2014 May 8;8(5):e2845. doi: 10.1371/journal.pntd.0002845.
Bian J, Kang HE, Telling GC. Quinacrine promotes replication and conformational mutation of chronic wasting disease prions. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6028-33.
Lee JS, Bevins SN, Serieys LE, Vickers W, Logan KA, Aldredge M, Boydston EE, Lyren LM, McBride R, Roelke-Parker M, Pecon-Slattery J, Troyer JL, Riley SP, Boyce WM, Crooks KR, Vandewoude S. Evolution of puma lentivirus in bobcats (Lynx rufus) and mountain lions (Puma concolor) in North America. J Virol. 2014 Apr 16. [Epub ahead of print]
Jalkanen AL, Coleman SJ, Wilusz J. Determinants and implications of mRNA poly(A) tail size - Does this protein make my tail look big? Semin Cell Dev Biol. 2014 Jun 5. pii: S1084-9521(14)00173-6. doi: 10.1016/j.semcdb.2014.05.018.
Chapman EG, Costantino DA, Rabe JL, Moon SL, Wilusz J, Nix JC, Kieft JS. The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production. Science. 2014 Apr 18;344(6181):307-10.
Chapman EG, Moon SL, Wilusz J, Kieft JS. RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA. Elife. 2014 Apr 1;3:e01892. doi: 10.7554/eLife.01892.
Walsh KP, Minamide LS, Kane SJ, Shaw AE, Brown DR, Pulford B, Zabel MD, Lambeth JD, Kuhn TB, Bamburg JR. Amyloid-β and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons. PLoS One. 2014 Apr 23;9(4):e95995. doi: 10.1371/journal.pone.0095995.
MIP hosted a very large (~1,400 attendees) and very successful meeting of the American Society for Virology last month. The meeting boasted a record number of scientific workshops (56) along with morning plenary sessions, state-of-the art lectures, lunch time workshops special topic/discussion tables, poster sessions and a keynote address by Nobel laureate David Baltimore. With ~300 international attendees from ~40 countries, the meeting truly had a global flavor.
A celebration to honor Dr. Barry Beaty and Dr. Patrick Brennan was held on April 2, 2014 at the Foothills Research Innovation Center. Dr. Beaty and Dr. Brennan were recognized for their outstanding achievements and exemplary service to CSU. We hope they are both enjoying their partial retirement!
Check out the photo gallery from the event.
In April, the Student Chapter of the American Veterinary Medical Association (SCAVMA) hosted the first annual FAC dodgeball tournament. The stakes were high as teams competed for best costume and the coveted "Champion of the Universe" trophy. In the end the "Bottom Quartile" defeated "The Sitting Ducks" to take home the trophy and "Prognosis: Grave" won for best costume. The tournament also settled an ancient rivalry between pathology and surgery. In what was called the "Balls of Truth Showdown" EJ Ehrhart's team,"Large Knives", defeated Felix Duerr's team, "Small Knives".
Micro major, Andy Bender loves science, but he has another passion too. Andy is a DJ for KCSU, Colorado State University’s non-commercial, student-run, campus radio station. KCSU focuses on college and alternative musical genres but also provides newscasts, sports updates, a public affairs talk show and Public Service Announcements. Right now Andy and his co-host, Jacqui Maes, have a two hour show from 11:00 pm to 1:00 am where they play "relaxed electronic/study music". They are hoping to get a more accessible time slot over the summer. Check out the live stream and tune into Andy during those late night study sessions!
Thirteen prospective MIP graduate students visited the CSU campus in February; one candidate visited on Monday, Feb 24th, and twelve visited on Friday, Feb 28nd. Both groups were given an overview of the Graduate program from Dr. Quackenbush, received tours of the Foothills facilities, met with the GEC, and met with individual faculty whose research programs were of interest to them. The students who visited on Friday were able to attend the CMB/MCIN/BMB/MIP Poster Symposium and then enjoyed a FAC with faculty and the Graduate Student Organization at Tap & Handle. Saturday morning, due to weather conditions, and after scraping ice off the vehicle windows they headed to Lory State Park to hike Arthur's Rock with Drs. Blair, Black, Quackenbush, Rovnak and Schountz. View more photos from the hike.
Micro Major, Samantha Guinn, wins the 2014-15 ASCSU Presidential Election
Samantha Guinn, a junior microbiolgoy major is the new president of ASCSU. Samantha and her running mate, Lance Li Puma, beat out three other campaigns with 1,484 votes. Their campaign "Fresh Approach, New Beginnings, focused on four separate platforms. Congratulations Samantha and Lance!
Read the Collegian article for the full story.
In April, MIP students enrolled in the Plan B masters and PhD programs had the opportunity to attend a career workshop. The event was held in the D-lab atrium of the South campus and featured four invited speakers. Rob Yemm from Leprino Foods; Dan Stinchcomb, founder of Inviragen; Ann Powers from the CDC and Dennis Pierro, Director of BioMARC. The goal was to highlight possible career choices in microbiology/biotech/food industry. Each of the speakers gave a short presentation about careers in their areas, and also talked about their own career experiences to help the students. The presentations were followed by a panel discussion based on the students' questions.
Good food, good beer and good people were all part of the MIP Annual Spring Picnic on Friday, May 9. MIPers and their families enjoyed Famous Daves BBQ while Greg Dean and Becky Trentlage poured the beer.
Thank you to Ida Tieman, Cathy Griffin, Andrea Franson and Becky Trentlage for organizing the event, and to the MSA and MSO students for their labor and financial help in making the picnic a success!
Megan Cassidy, an MIP alumni, was recently chosen for the AP Biology Leadership Academy. She is currently a teacher at Horizons High School in Thornton, CO and judging from the letter below, she is already making a difference. Congratulations Megan!
Dr. John Spencer is part of a documentary featuring his research diagnosing leprosy in Breves, Brazil. The documentary was produced with funding from the Brazil Ministry of Health and shadows a team as they vist homes and schools in the Amazon of Brazil. Be sure to check out the video on youtube!
Funding for Publication Costs
The Colorado State University Libraries has allocated $45,000 to establish the Open Access Research & Scholarship (OARS) Fund. CSU tenured/tenure track faculty authors are eligible to receive up to $2,000 to support article processing fees for one article. The 2013-2014 academic year application period for OARS funding closed May 31, however, the website indicates OARS will be accepting applications again in mid-July. Please email email@example.com if you would like to be notified when the program begins accepting applications again.
The video Jordon Steel submitted for the ASM Global Video Challenge - People's Choice Award tied for 3rd place. Jordan's video answered the question how is your microbiology making the world a better place? Jordan will receive a $100 cash prize and free registration to the ASM general meeting. His video was honored at the State of the Society Address on Monday, May 19. Congratulations Jordan!
2014-2015 Fiscal Year Holiday schedule
Friday, July 4
New Grant Awards
John Belisle, "Mycolic Acid Assay Development and Testing", Catalysis Foundation
Lars Eisen, "Novel Trap for Ticks and Fleas Incorporating a CO2 Generator", TDA Research, Inc.
Angelo Izzo, "Treatment of Irradiated M. Tuberculosis Strains for Use as Vaccines", Mico Bio, Inc.
Herbert Schweizer, "ALX-009 Efficacy Testing Against Priority Pathogens", Alaxia
Schweizer, Herbert, "Biapenem/RPX7009 Activity Against Burkholderia Pseudomallei", Rempex Pharmaceuticals
Mathiason, Candance, "Detection and Characterization of Blood-borne Prions", NIH-NIAID
Beaty, Barry, "Metabolomics-based Discovery of Small Molecule Biomarkers for Noninvasive Dengue Diagnosis and Prognosis", NIH-NIAID
Dobos-Karen, "TB Surrogate Markers for Assessing Response to Treatment (TB SMART Study)", University of California, San Francisco
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