Volume 7, Issue 5, May 2010
Congratulations to Erica Suchman for being named a University Distinguished Teaching Scholar - the highest honor recognizing teaching excellence conferred by our University. She is the first MIP faculty member to receive this award and there is absolutely no doubt that it is truly well-deserved. This may also be a boon to the scarf industry as other instructors rush to emulate her teaching style. Way to go Erica!!!
Stephanie Lehman was recognized as the Outstanding Graduating Microbiology Senior at the May 2010 commencement ceremony. Stephanie has been a terrific student for a long time. Based on her excellent academic performance in high school and potential for success in our undergraduate microbiology degree program, she received the Microbiology Undergraduate Scholarship as an incoming freshman, Indeed, Stephanie has more than met our expectations of being a “successful” student. She has earned very good grades not only in the rigorous curriculum required for a B.S. degree in Microbiology, but also in the additional coursework required for completion of the Honors Scholars Program.
Stephanie was also a Hughes Undergraduate Research Scholar. She began working in the laboratory under the direction of Dr. RoxAnn Karkhoff-Schweizer in her freshman year, and has continued to perform research there for all four years at CSU. It is evident that this experience honed Stephanie into a quite an accomplished young researcher: she received College Honors for a poster presentation at the 2008 CSU Undergraduate Research Symposium, was then awarded a summer research fellowship by the American Society for Microbiology and presented her research data at the national ASM meeting in Philadelphia. The content and presentation of her Honors research thesis rivaled that of many Masters’ degree theses.
Obviously, Stephanie was very busy with her studies and research responsibilities, but she still somehow found the time to be an active member of the Microbiology Student Association. As the webmaster, she created a very nice homepage for this organization, and this year she served as its president of MSA She was also the president of the CSU Swing Dance Society and a swing dance instructor!
Stephanie is now embarking on an exciting new adventure. She recently accepted a position with the Batelle National Biodefense Institute, which is part of the Department of Homeland Security in Frederick, Maryland, where she will research bacterial select agents (bacterial pathogens with the potential for use in biowarfare).Congratulations Stephanie and best of luck in your future endeavors!
Dr. Klein Recognized for Commitment to Students
Congratulations to Don Klein for being nominated as a "Favorite Faculty or Staff Member" for his student-centered education efforts and has been invited to participate in the 6th annual CSU Meet & Greet Program at the end of August.
Congratulations to Jenny Harding and Erica Suchman for receiving awards at the College's Scholarship and Awards Luncheon in recognition for their Outstanding Service
Erica Suchman - Innovative Instructional Methodology Award in Undergraduate Education
Jenny Harding - College Outstanding Employee Service Award
CSU Student Winners:
Undergraduate Poster-2nd place
Undergraduate Oral-1st place
There were 170 entries at the 2010 CURC, 18 were MB students, and 10 had MIP mentors.
Congratulations to the following MIP students and mentors who received awards at this year's event:
"Blockade of nuclear factor kappa b prevents mptp-induced expression of inducible nitric oxide synthase in primary astrocytes"
"Quantification of the differential effects of rice bran varieties on immune response modulation in vitro. "
"How the Hec1 Protein Affects Kinetochore Oscillations in Mitosis "
MIP Student Presentations at the 2010 CURC
2010-11 Microbiology Undergraduate Student Scholarship Recipients
Beulah & Doyle Blair Memorial Scholarship
2010-11 Microbiology Graduate Student Scholarship Recipient
Kirke L. Martin Memorial Scholarship
On May 4, Davis M. Seelig, DVM, presented his final seminar entitled, "Chronic Wasting Disease in Transgenic Mice and White-Tailed Deer - Prion Trafficking and Pathogenesis". His PhD defense immediately followed the seminar. His advisor is Dr. Edward Hoover
In the News...
Drs. Bob Ellis and Ralph Smith were extensively quoted in an article in the Loveland Reporter-Herald on the opening of RIC Building. Check it out on the Reporter-Herald web site.
Mycobacteriophage Ms6 LysB specifically targets the outer membrane of Mycobacterium smegmatis
F. Gil, Anna Grzegorzewicz, M.J. Catalao, J. Vital, Mike McNeil and M. Pimentel
Microbiology 156: 1497 (2010)
When bacterial viruses (aka bacteriophage) decide its time to lyse the cell, they have to figure out how to get through that big bad layer of peptidogylcan on the surface. If your career choice was to be a mycobacterial-specific virus, you would have an even bigger problem: covalently attached to a thick peptidoglycan layer is a gooey mess of arabinogalactan esterified to mycolic acids. Want to know how the heck the 60+ known mycobacteriophage get through this ‘acid fast’ barrier? Just take a trip down to the basement of the Micro Bldg and ask Anna and Mike.
With their collaborators from the Iberian Peninsula, they made extensive use of TLC and LC-MS analyses to identify the substrates of LysB, one of 5 proteins encoded by the lytic cassette of mycobacteriophage Ms6. They found strong evidence that the protein specifically cleaves two things found in the complex surface coat of mycobacteria: (1) the arabinoglactan-mycolic acid bond and (2) the bond between mycolic acids and trehalose in a compound called TDM or cord factor. These are the first published data on substrate preference for the Ms6 LysB protein and confirm 2009 results from Graham Hatfull’s lab on a similar activity they studied from the related mycobacteriophage D29. Finally, the group assessed whether the LysB protein could directly inhibit mycobacterial growth when added to cultures - and thus potentially pursue LysB as a novel anti-mycobacterial compound. Unfortunately, the bacteria outsmarted the experiment and used its thick cell surface coat to prevent access of LysB to its substrates that are buried deep within the acid fast cell wall.
We chose this paper as our end of the Spring semester MIPaper of the Month® for three main reasons. First, it contributes some fundamental core knowledge to our understanding of how mycobacteriophage interact with their complicated host cell. Given the therapeutic potential of mycobacteriophage and their encoded proteins, this study has both basic and applied scientific interest. Second, this study once again illustrates the international nature of the research endeavors of MIP investigators as well as the recognition of our MRL researchers around the globe. Finally, it also gives the MIP community a glimpse of what goes on in the basement of the Micro building. So next time you get into that snazzy, refurbished Micro elevator – go ahead and push that ‘B’ button and head down to say hello to Mike and the gang. Tell ‘em the MIPnews sent ya.
MIP Publications Late April 2010 - Early May 2010
Ordway DJ, Shanley CA, Caraway ML, Orme EA, Bucy DS, Hascall-Dove L, Henao-Tamayo M, Harton MR, Shang S, Ackart D, Kraft SL, Lenaerts AJ, Basaraba RJ, Orme IM. Evaluation of standard chemotherapy in the guinea pig model of tuberculosis. Antimicrob Agents Chemother. 2010 May;54(5):1820-33.
Reese SM, Mossel EC, Beaty MK, Beck ET, Geske D, Blair CD, Beaty BJ, Black WC. Identification of super-infected Aedes triseriatus mosquitoes collected as eggs from the field and partial characterization of the infecting La Crosse viruses. Virol J. 2010 Apr 22;7(1):76.
Lambert AJ, Blair CD, D'Anton M, Ewing W, Harborth M, Seiferth R, Xiang J, Lanciotti RS. La Crosse virus in Aedes albopictus mosquitoes, Texas, USA, 2009. Emerg Infect Dis. 2010 May;16(5):856-8.
Brown AC, Eberl M, Crick DC, Jomaa H, Parish T. The nonmevalonate pathway of isoprenoid biosynthesis in Mycobacterium tuberculosis is essential and transcriptionally regulated by Dxs.
Mehaffy C, Hess A, Prenni JE, Mathema B, Kreiswirth B, Dobos KM. Descriptive proteomic analysis shows protein variability between closely related clinical isolates of Mycobacterium tuberculosis.
Propst KL, Troyer RM, Kellihan LM, Schweizer HP, Dow SW. Immunotherapy markedly increases the effectiveness of antimicrobial therapy for treatment of Burkholderia pseudomallei infection.
Winters AM, Eisen RJ, Delorey MJ, Fischer M, Nasci RS, Zielinski-Gutierrez E, Moore CG, Pape WJ, Eisen L. Spatial risk assessments based on vector-borne disease epidemiologic data: importance of scale for West Nile virus disease in Colorado.
Sottnik JL, Duval DL, Ehrhart EJ, Thamm DH. An orthotopic, postsurgical model of luciferase transfected murine osteosarcoma with spontaneous metastasis.
Mathiason CK, Hayes-Klug J, Hays SA, Powers J, Osborn DA, Dahmes SJ, Miller KV, Warren RJ, Mason GL, Telling GC, Young AJ, Hoover EA. B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease.
Gil F, Grzegorzewicz AE, Catalão MJ, Vital J, McNeil MR, Pimentel M. Mycobacteriophage Ms6 LysB specifically targets the outer membrane of Mycobacterium smegmatis.
Khoo CC, Piper J, Sanchez-Vargas I, Olson KE, Franz AW. The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti.
Yan R, Lynn NS, Kingry LC, Slayden RA, Dandy DS, Lear KL. An optical waveguide array biosensor for serology - biomed 2010.
Balachandran A, Harrington NP, Algire J, Soutyrine A, Spraker TR, Jeffrey M, González L, O'Rourke KI. Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): early detection and late stage distribution of protease-resistant prion protein.
White SN, O'Rourke KI, Gidlewski T, VerCauteren KC, Mousel MR, Phillips GE, Spraker TR. Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue.
Weiner CM, Rosenbaum MD, Fox K, Mason G, Bielefeldt-Ohmann H, Veeramachaneni DN, Vandewoude S. Cottontail rabbit papillomavirus in Langerhans cells in Sylvilagus spp.
Dickson AM, Wilusz J. Polyadenylation: alternative lifestyles of the A-rich (and famous?).
Klein, DA. Have they proven that mycobacteria are present “in the Mist?” Microbe 2010 5:189.
On May 12, 2010, a retirement reception honoring Ralph Smith was held at the newly opened RIC Building at Foothills Campus. Friends, family and colleagues enjoyed fabulous food and great conversation while honoring and thanking Dr. Smith for his dedication and numerous accomplishments while at CSU.
Check out the Reception Photo Gallery
Marcia's two precious kitties Milo and Zoe. They are looking for a loving new home with someone just like you! Zoe is a cuddly, snuggly, lap kitty. Milo is a little more sophisticated and prefers to sit next to you to be petted. They are ~5 years old, fixed, and up to date on all their shots. Would you have room in your home for these little lives that Marcia cared so much for? Please feel free to contact Katy Quinn with any questions at 970-420-7982 or Katrina.Quinn@colostate.edu.
Newly Elected 2010-11 Officers of the Microbiology Student Association
President: Ryan Goffredi
Congratulations to all.
Hey PIs – ever wonder what your lab personnel are doing when you’re off traveling? On Friday, April 23, DJ’s Beano and Derek from 99.9 The Point radio station served up more than just Today’s Best Music when they brought the Dobos Lab lunch from the Rustic Oven. Keri Wright submitted the winning entry for the lab in the radio station’s contest. PI Karen Dobos and lab manager Megan Lucas were away in Bethesda for the annual TB contract meeting and didn’t get to join in the festivities. The contest is still running on the station’s website, so enter today – and don’t forget to tell them when your boss is away……!
Congratulations to Jeffrey Wilusz for being selected as the next leader of the Rocky Mountain Branch of ASM!
Dr. Rick Lyons, formerly with the University of New Mexico Health Sciences Center, is joining CSU to oversee the Infectious Disease Research Center on the University's Foothills Campus and the infectious disease Supercluster. Lyons, a doctor of internal medicine, has extensive experience in infectious disease research and leadership. For the past 16 years, while at New Mexico Health Sciences Center, he was a professor of medicine in the Department of Internal Medicine and director of the Center for Infectious Disease and Immunity.
Payroll Shenanigans for Hourly Employees
Timesheets submitted for the May 22-June 4 pay period will not be paid on June 18th. Due to CSU fiscal year end policy, you’ll have to wait until Thursday July 1, 2010 for your check. Please plan accordingly.
Best Wishes Lisa!
Lisa Anaya, long-time MIP accounting technician and manager at Foothills Campus, left MIP on May 14 for a promotion at Sponsored Programs. Lisa has been in the College of Veterinary Medicine for over 13 years and been a valuable team member. She will be missed! We wish her the best in all her future endeavors.
Hi! I am Shannon Pfohl and I am the newest accounting tech in the Microbiology building. I became a Ram fan almost six years ago when I started working for CSU in the Athletic Department. I have learned a lot about the processes and procedures of working for the University and am now looking forward to learning what it takes to work in a more academic department.
My husband and I have three children, our boys are 22 and 21 and our daughter is 16. We also have quite an extended family in the area and very much enjoy spending time together. You will find us most weekends either exploring the mountains four wheeling in our jeep or having video game tournaments with the whole family. I look forward to working with you all, stop by and say hi sometime!
Hi, I am Tammy Taylor, the new accounting tech at RIC. I am a Colorado native, I grew up in Kremmling (small town near Steamboat Springs) then went to college at CSU. Until now I have worked in private industry, my husband and I owned our own business for the past fifteen years and decided it was time for a change. We have two teens that go to Fossil Ridge High School, my daughter loves photography and my son is a very good golfer. I enjoy reading, working in the yard, camping, and fishing.
LAST CALL FOR TICKET RESERVATIONS!!!
When: Sunday June 20th at 1PM
Interested? Contact Jeff Wilusz for more details and ticket reservations.
The new 72,000-square-foot, $53 millon Reseach Innovation Center (RIC) was unveiled at the ribbon cutting event held Tuesday, May 11. RIC is a hybrid of business office space, university researcher offices and state-of-the-art bioscience laboratories, conceptualized to build university partnerships with CSU startup businesses and existing businesses. The facility will house efforts to develop, perfect, analyze and market vaccines, tests and treatments for a variety of diseases including those that infect and kill millions of people and animals around the world each year, such as, West Nile virus, drug-resistant tuberculosis, yellow fever, dengue fever, hantavirus, plague, and tularemia.
Renovations to Path 107/107A began on Monday, May 17. The project is scheduled to last for a two week period where the wall between these two rooms is going to be removed and shelves and wallpaper are coming down. We'll end up with a very usable conference room in the Path facility. Please excuse the dust and additional traffic.
Marcia Boggs has been my MIP department contact person upon since applying to the graduate program last year. She has always been very open, informative, friendly and helpful. I have enjoyed talking with her, sharing stories and even having lunch with her. She will remain one of my favorite people here at CSU. I'm grateful I got to know her and she will be greatly missed.
I knew Marcia really well, we used to hang out and talk Russian lit. I am Russian, and she was the only person in the US I knew who read and really liked one of our best loved books in Russia: Mikhail Bulgakov's "The Master and Margarita". It's an extremely complex work that is not too well known here, it's also a book I absolutely love. We used to hang out and discuss the various detail and interpretations and hidden meanings in that work. I am really going to miss her, she was a great lady with a wonderful taste in literature!
Marcia always had a few minutes to listen to me fret about my thesis, my course discrepancies, or the unreported grades for my courses. We would sit down at the little table in her office and talk, and I would comment to myself about how colorful everything was in there. It made me think that I should add more stickers or something around my own desk and workspace. Marcia always asked me how my job search was going. When I told her that I was going to move back to the east coast when my residency and MS degree were complete, she told me not to go and that I would be missed. Marcia made me feel special and appreciated during some of the more stressful times I had in MIP; I appreciate her for her kindness.
I am truly saddened by the passing of Marcia. Even though we only met about a year ago, she made my first year as a graduate student that much easier. She was such a caring person, and would always have a smile, a warm hello, and genuine concern for you when you saw her. It was apparent every day that she cared so much about the graduate students, and the department will not be the same without her. I will miss her, and would like to thank her for all the help she gave.
When I first stepped in CSU, she was the first person I met, I had been talking to her by email since months ago and even talked to her over the phone to ask questions about the program and registration procedures. Im a foreigner and althought I passed the TOEFL with an excellent score I had a LOT of troubles with the language the firsts months I lived in this country, when my parents came to see the school and the town, my mom was feeling very sentimental because I never had lived so far away from home, Marcia hold her hand and told her, "I will take care of her as she was my own daughter". And she did. I was sitting on her office almost every week of my first semester, asking about everything, living off campus, getting a drivers license, how was I feeling about being away from home and without knowing anyone around, she was so kind to me all times, she always had time to explain to me anything I would want to ask her, even if it was about the snow (that was new to me too).
I went to her office and told her when my boyfriend after a very long relationship broke up with me because I was in a foreigner country, she said it was for the best, she was totally right.
I will always remember her laughing, smiling, talking about her grandchildren, and helping everyone at all moments. She is a friend and she will always be in a very special place in my heart, the place that corresponds to a second mom. Thank you Marcia for being an angel to me, God bless you.
Marsha-- you made it easy transitioning here as a new student. Your heartfelt smiles and comforting presence will be missed by all.
Thank you, Marcia, for your willingness to always help students no matter how busy you were at the time. I will never forget your genuine care for others, enthusiasm, smile, and sense of humor. You truly lit up our department and we will miss you!
Marcia’s kindness and encouragement were invaluable to me even before I was a graduate student. She was the first person I met when I began the application process, and I continued to rely on her gentle guidance after I became a student. I will miss her warmth, patience and steady good humor.
Marcia was always so happy and welcoming when I stopped by, and would set aside whatever she was doing to chat with me. I know she genuinely cared how I was doing, and I always left her office feeling happy and hopeful. She helped me and many other students get though the struggles of a graduate degree and will be greatly missed. Thank you Marcia!
I think this story is a nice example of how Marcia touched all of our lives. We were all heading out to one of the FACs at Coopersmiths during new student recruiting. Marcia was really pooped and she had told me she was not sure if she was going to be able to come. I told her we would all love to see her and maybe she could just stay a little while and then head home. Not surprisingly, that did not happen. So, quite awhile later she made her way over to our group to say goodbye. She chatted for a bit and then moved off. Some time later, someone in the group said "Speaking of popular, look, Marcia is still here and she has been trying to leave for an hour". We watched as she moved away from that group only to be waved over by the next table. It was practically last call by the time she had been able to say hello to all of the people there that loved her. I think I would give anything to be able to tell her that one last time. That I love her. That we all do.
Marcia was my first contact when I arrived at CSU and she made me feel right at home. I remember the way she worked the crowd at the MIP fall gathering my first semester with that big smile on her face...just her presence made everyone (new students like myself included) at ease. She has always been willing to listen, talk, and help me through whatever happened to be slowing me down. We shared the common bond of loving life in the mountains and she was always asking me how things were going up Rist Canyon. We will miss you greatly Marcia...
I am certain that the vast majority of graduate students who came in contact with Marcia during their years in the MIP grad program feel the same way about her: Marcia was like a mom to us all, and we truly loved her and appreciated the significant time and sincere caring she invested in each of us. I remember one time after a seeming crisis, I wound up in Marcia’s office, talking things out. As always, talking with Marcia made me feel like things would be OK, and I recounted this to my mom on the phone later that night. Well, the next day I received an email from my mom with the subject: "God Bless Marcia." She really meant that. I think that many of our families were heartened to know that we had an advocate and a friend in Marcia, and I know that they will be eternally grateful.
Over the years, I was fortunate to forge a relationship with Marcia that extended beyond graduate school, as many of us were. That’s just the kind of person Marcia was, the kind of person that people want to have her in their lives. She came to know my parents, and they too mourn the loss of her as a friend. My husband, John, and I loved spending time with Marcia, whether over lunch or at her house planting tomatoes in the garden. She was a dear friend to us both. In the last months, we have cherished the opportunity to talk with her about the impending arrival of our first child. Our daughter is due any day now, and we are having a difficult time accepting that we will not have the chance to introduce her to Marcia. That said, as we enter parenthood, we both consciously strive to be even close to as good a parent as Marcia was to her own children, and to all of us students.
Marcia had an amazing smile, one that I will never forget. No matter how bad a day it was she would make me smile too and she was always there if you needed a friend to talk to. She would come visit us in the TA office, during our first year, just to see how teaching, classes and our rotations were going. I don't know how many times she asked me "Have you decided on a lab yet?" with such excitement. She loved hearing what everyone was doing, and she really cared for everyone of us. I will miss her dearly.
‘It is a good morning exercise for a research scientist to discard a pet hypothesis every day before breakfast. It keeps him young. ’
~ Konrad Lorenz
New Grant Awards
John Belisle, "Evaluation of GSK2145083 - Pharmacokinetics and Efficacy against Y. pestis in Mice", GlaxoSmithKline Pharmaceuticals Ltd.
Brian Foy, "New Tent Trap for Vector Surveillance ", IST-Infoscitex Corporation
Michio Kurosu, "Targeting MraY: Synthesis and Validation of MraY Inhibitors", NIH-NIAID
Mark Zabel, "Development of a Cell Culture-Based In Vitro Prion Amplification Assay as a Diagnostic Tool for CWD", Intl Foundation for Ethical Research, Inc.
Do you have NEWS or PICTURES you would like to share?
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|MIP Newsletter Volume 7, Issue 5, May 2010|
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