<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"> <head> <title>MIP Newsletter, CVMBS, Colorado State University</title> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"/> <style type="text/css"> .alert {color:#FF0000; font-weight:bold;} .blue {color: #0033FF; font-weight:bold} .bluelg {color: #0033FF; font-weight:bold; font-size:large;} .bluenb {color: #0033FF} .blueltlg {color:#666699; font-weight:bold; font-size:x-large;} .blulg {color:#333399; font-weight:bold; font-size: large;} .brwnlg {color:#996633; font-weight:bold; font-size: large;} .cntr {text-align:center;} .goldlg {color:#CC9900; font-weight:bold; font-size: large;} .green {color: #339933; font-weight:bold} .greenlg {color: #339933; font-weight:bold; font-size:large;} .greennb {color: #339933} .left {float: left;} .lrgbold {font-size:large; font-weight:bold} .news {font-family:"Courier New", Courier, monospace; 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vertical-align:middle } .bullgreen {list-style-image:url(../newsletter/images/bullet_admin_grn.jpg); vertical-align: bottom} .bullgrnpk {list-style-image:url(../newsletter/images/bullet-grnpk.gif); vertical-align:bottom} .bullyellow {list-style-image: url(../newsletter/images/bullet_ylw.gif); vertical-align:bottom} .bullpencil {list-style-image: url(../newsletter/images/mini_pencil.gif); vertical-align:baseline} .important {font-weight:bold; text-decoration:underline} .announce {font-family:Verdana, Arial, Helvetica, sans-serif; text-align:center; font-weight:bold;} #title {font-size:36px; font-face: Times New Roman, Times, serif; font-weight:bold; vertical-align:middle; color:#FFFFFF; background-image: url(../newsletter/images/title_bg.jpg); } #footer {font-size:18px; font-face: Times New Roman, Times, serif; font-weight:bold; vertical-align:middle; color:#FFFFFF; background-image: url(../newsletter/images/title_bg.jpg); } </style> </head> <body> <p>&nbsp;</p> <div id="title" align="center"> <p> Microbiology, Immunology &amp; Pathology<br/>NEWSLETTER </p> </div> <div align="center"> <hr/> <font face="Times New Roman, Times, serif" size="+1">Volume 6, Issue 1<br /> January 2009</font></div> <table width="933" border="5" cellpadding="4" cellspacing="2" align="center"> <tr> <!-- Beging First Column --> <td width="35%" valign="top"> <div align="center"><img src="../newsletter/images/spotlight.gif" width="303" height="50"></div> <hr/><div align="center"> <img src="../newsletter/images/outstanding_senior.gif" width="300" height="50" "outstanding graduating senior" /><br/> <img src="../newsletter/images/j0336389.gif" width="64" height="64" alt="mortarboard"/></div> <p><img src="../newsletter/photos/higgins-outstanding.jpg" width="110" height="155" alt="Jonathan Higgins" align="left" hspace="10"/> <strong>Jonathan Higgins</strong> was awarded the Outstanding Graduating Senior Award at the December 2008 commencement ceremony.&nbsp; The award is given in recognition of academic excellence and/or service to the department or the community.&nbsp; </p> <p>Jon is truly an outstanding student, graduating <em>summa cum laude</em>, with a cumulative GPA of 3.988, an especially impressive achievement given the rigorous curriculum required for a degree in microbiology.</p> <p>For the last several years, Jon has worked on tuberculosis research projects in the laboratories of Dr. Ian Orme and Dr. Mercedes Gonzalez-Juarrero.&nbsp; He received &ldquo;Highest Honors&rdquo; for a poster presentation of his research data at the 2008 CSU Celebrate Undergraduate Research &amp; Creativity Symposium and he is a co-author of an article published in the <em>Journal of Immunology</em>.</p> <p>Jon is an outstanding student, a fine researcher, and a true humanitarian.&nbsp; He has spent the last two years as a volunteer with an aid organization in India, where he works to help improve the lives of the Dalits; people belonging to the lowest social class in India who live in extreme poverty and suffer from severe social stigma.&nbsp; Jon has created a beautiful website documenting his experiences in India. (<a href="http://fortheleastofthese-india.blogspot.com/2008/08/blog-post.html" target="_blank">http://fortheleastofthese-india.blogspot.com/2008/08/blog-post.html</a>)<br> Looking at the pictures he has taken and the words he has written, it is very clear that the people of India have deeply touched Jon&rsquo;s heart.&nbsp; It is hard not to believe that the Indian people have been equally touched by Jon&rsquo;s acts of generosity, compassion and friendship.</p> <p>&nbsp;Those of you who know Jon will not be surprised to hear of his achievements, because you already know that Jon strives for excellence in everything he does.&nbsp; You might be surprised by just how much he has done though, because Jon is a very modest person who does not boast about or expect credit for his accomplishments.&nbsp; In fact, he was probably surprised to be selected as the outstanding student!&nbsp; Jon&rsquo;s humility is one of his finest attributes.</p> <p>We in MIP are not the only ones to be impressed with Jon.&nbsp; He has already received early acceptance notification for admission into two medical schools: Ohio State and Northwestern Universities.&nbsp; The list of acceptance letters Jon receives is likely to grow, and he will have to make a difficult chose as to which to attend.&nbsp; One thing is for sure, Jon is going to medical school and he will fulfill his long-time goal to become a physician.&nbsp; And, knowing Jon, he will become a really, really good one!</p> <p>Congratulations and best of luck in your future endeavors, Jon!</p> <hr/> <img src="../newsletter/photos/gentryweeks-cert.jpg" width="300" height="212" alt="Claudia"/> <p>Congratulations go out to <strong>Dr. Claudia Gentry-Weeks</strong>, Associate Biosafety Officer (and of course MIP faculty member), who successfully met the requirements and passed the exam to become a certified Registrant of the National Registry of Microbiologists (NRM) in the area of Biological Safety Microbiology. Way to go Claudia!</p> <hr/> <img src="../newsletter/images/deanslist08.jpg" width="300" height="211" alt="Dean's List"/> <p align="center">Khloud Alsafwani<br/> Dulat Bekbolsynov <br/> Diane Bergstedt <br/> Erin Breland <br/> Jason Christianson <br/> Ana Dalbey <br/> Kristyn Degi <br/> Jacob Dunham <br/> Jamie Everman <br/> Petra Gest <br/> Ryan Goffredi <br/> Tirrel Grovenstein <br/> Holly Hamilton <br/> Dennis Hanson <br/> Jonathan Higgins <br/> Courtney Hillard <br/> April Hohnbaum <br/> Theodore Johnson <br/> Aslynn Jones <br/> Jason Kasvin-Felton <br/> Anna Kellund <br/> Lauren Kinner <br/> Natalie Kirk <br/> Amy Leach <br/> Christopher Lehmann <br/> Tom Lofe <br/> Matthew Marquez <br/> Ian Mcmillan <br/> Erin Mikkelsen <br/> Gwynnevere Milner <br/> Katherine Mladinich <br/> Michelle Moore <br/> Laura Nelson <br/> Brent Nolan <br/> Melissa North <br/> Melissa Po <br/> Natalia Reim <br/> Amber Roberts <br/> Kristen Ruckman <br/> Linda Smith <br/> Kristin Spencer <br/> Jaime Stearns <br/> Stephanie Sunshine <br/> Kristina Tafoya <br/> Karen Trott <br/> William White </p> <hr/> <p class="greenlg" align="center">Michael Phelps ain't the<br/> only one 'round here<br/> getting gold medals</p> <p><img src="../newsletter/photos/ellis-service.jpg" alt="Bob Ellis" class="left" />Congratulations to Dr. Robert P. Ellis for receiving the Russian Academy of Agricultural Science, Division of Veterinary Medicine, Gold Medal of Achievement in the field of Veterinary Science, by Dr. Taras I. Aliper and Dr. Alexei D. Zaberezhny of the D. I. Ivanovski Virology Institute and the Russian Veterinary Biologics company NARVAC. The medal was presented to Dr. Ellis December 2008. </p> <div class="cntr"><img src="../newsletter/images/ellis-russian-award.gif" alt="award" /></div> <p>In addition, Dr. Ellis has also recently been elected as the President of the American Biological Safety Association (October 2008-October 2009).</p> <hr /> <p><img src="../newsletter/images/new.gif" alt="new" class="left" hspace="10" />Think the upcoming inauguration, the switch to all-digital TV, the start of the Year of the Ox or the release of Springsteen s 26th album are exciting?? Wait  til you check out this new addition to MIPnews for 2009. Every month, we will highlight one of our department s publications listed in the lower left column.</p> <img src="../newsletter/images/pub-highlight.gif" alt="pub highlight" /> <p class="lrgbold">Who knew mycobacteria could be so sweet?</p> <p>In an article published in the January 2009 edition of the journal Glycobiology, Mark Sartain and John Belisle report a significant milestone in their group s efforts to characterize the glycoproteins of <em>Mycobacteria tuberculosis</em> (Mtb). Yes Virginia,  glycoproteins is not a typo - bacteria can add sugars to (aka glycosylate) their proteins. It s been known for about 20 years that certain Mtb proteins can bind ConA, a clear indication of the presence of sugars. This was definitively verified by Karen Dobos and colleagues using mass spectrometry in 1996. In the current study, Mark and John focused on a superoxide dismutase (Sod) called SodC that they showed two years ago was secreted by Mtb during their global search for Mtb antigens in culture filtrates in 2006. Sods (no relation to the grass we tear up on the fairways of local golf courses .) are rather thought to be very important for bacterial survival of the respiratory burst that macrophage use to kill invaders. So in addition to being an Mtb antigen, SodC likely also plays a role in bacterial virulence and hence holds a potential key towards unlocking a future therapeutic avenue for tuberculosis.</p> <p>Mark and John overexpressed SodC as a recombinant protein and the presence of attached sugars was investigated by a combination of mass spectrometry and site-directed mutagenesis. Evidence was found for the presence of 5-6 mannose residues in the N-terminal region of the SodC protein (mannose is a type of sugar  not a masculine place to rest your glasses). Interestingly, in addition to being attached to threonine residues (which have been previously implicated in Mtb glycosylation), they also found fairly convincing evidence for glycosylation of serine residues.</p> <p>There are two main reasons we think this paper is special. First of all, this is the first demonstration of mannose addition to serines in Mtb. This novel observation should significantly expand future explorations into Mtb glycoproteins by including these amino acids into the detailed analyses. Second, the study provides additional information to help solve the puzzle of exactly what constitutes an Mtb glycosylation site/signal. The current model suggests that glycosylation occurs in a domain rich in Pro, Ala, Thr and Ser residues with the addition of a mannose residue often occurring at a Thr or Ser residue positioned within two bases downsteam of a proline. The sugar linkage appears to be &alpha;1-2 in Mtb but &alpha;1-3 in the glycoproteins analyzed to date from the related mycobacterium <em>M. smegmatis</em>. It will be interesting to see if this apparent species-specific mechanistic distinction holds up in additional analyses.</p> <p>A final key question raised by Mark and John s work is why the heck does Mtb bother making a glycosylated SodC in the first place? After all, the SodC of Mtb is the only glycosylated member of the Cu,Zn Sod family characterized to date. Analysis of crystal structures suggest that the glycosylated N terminus of SodC is rather flexible and rather unstructured. Perhaps the addition of mannose residues to this unstructured segment influences the efficiency of proteolytic cleavages thought to naturally occur in the acetylated N terminus. These events modulate protein localization since the N-terminus is thought to be involved in membrane associations. Look for the answers to these and other interesting Mtb puzzles in future Belisle lab papers.</p> <hr> <p><img src="../newsletter/images/bullet.gif"><font size="+1"><strong> MIP Publications Late December - Early January 2009 </strong></font> </p> <ul> <li>Calisher CH. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19090612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">Public health or pubic health: is there a difference?</a> Croat Med J. 2008 Dec;49(6):856-60.</li> <li>Coler RN, Dillon DC, Skeiky YA, Kahn M, Orme IM, Lobet Y, Reed SG, Alderson MR. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19000730?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">Identification of Mycobacterium tuberculosis vaccine candidates using human CD4(+) T-cells expression cloning.</a> Vaccine. 2009 Jan 7;27(2):223-33.</li> <li>Narayanasamy P, Eoh H, Crick DC. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19088853?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">Chemoenzymatic synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol: a substrate for IspE.</a> Tetrahedron Lett. 2008 Jul 21;49(29-30):4461-4463.</li> <li>Phillips B, Powers BE, Dernell WS, Straw RC, Khanna C, Hogge GS, Vail DM. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19122062?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank"> of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma in dogs.</a> J Am Anim Hosp Assoc. 2009 Jan-Feb;45(1):33-8.</li> <li>Reese SM, Blitvich BJ, Blair CD, Geske D, Beaty BJ, Black WC 4th. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19114023?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank"> Potential for La Crosse virus segment reassortment in nature.</a> Virol J. 2008 Dec 30;5(1):164.</li> <li>Rholl DA, Trunck LA, Schweizer HP. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18952878?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">In vivo Himar1 transposon mutagenesis of Burkholderia pseudomallei.</a> Appl Environ Microbiol. 2008 Dec;74(24):7529-35.</li> <li>Sartain MJ, Belisle JT. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18842962?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">N-Terminal clustering of the O-glycosylation sites in the Mycobacterium tuberculosis lipoprotein SodC.</a> Glycobiology. 2009 Jan;19(1):38-51.</li> <li>Sokoloski KJ, Wilusz J, Wilusz CJ. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19111175?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">The preparation and applications of cytoplasmic extracts from mammalian cells for studying aspects of mRNA decay.</a> Methods Enzymol. 2008;448:139-63.</li> <li>Stalford SA, Fascione MA, Sasindran SJ, Chatterjee D, Dhandayuthapani S, Turnbull WB. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19082015?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A.</a> Chem Commun (Camb). 2009 Jan 7;(1):110-2.</li> <li>Wilusz J. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19125167?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum">RNA stability: is it the endo' the world as we know it?</a> Nature Struct Mol Biol. 2009 Jan;16(1):9-10</li> <li>Woolhiser LK, Hoff DR, Marietta KS, Orme IM, Lenaerts AJ. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18852269?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" target="_blank">Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.</a> Antimicrob Agents Chemother. 2009 Jan;53(1):306-8.</li> </ul></td> <!-- Begin Second Column --> <td valign="top"><div align="center"> <img src="../newsletter/images/happenings.gif" width="250" height="100" /> </div> <hr> <img src="../newsletter/images/adopt.gif" width="300" height="80" alt="adopt a family" /><br /> <img src="../newsletter/photos/elves.jpg" width="300px" "elves" /> <p>Pictured above are some of the MIP Adopt-A-Family &lsquo;elves&rsquo; hard at work wrapping some of the more than <strong class="large">100</strong> presents collected for our two &lsquo;adopted&rsquo; families for the holidays. Thanks to all for this truly amazing show of generosity! </p> <img src="../newsletter/photos/adopt-thanks-08.jpg" width="298px" height="416px" alt="photo gallery" /> <p>A thank you card from the family is pictured above, <a href="mipnews-jan2009-p2.htm" target="_blank">click here</a> to see a larger image.</p> <p>Carol Wilusz, (aka Santa), would like to thank Lesley Jones, Marcia Boggs and Alexa Dickson for helping with the wrapping and sorting. Wendy Seay and Carolyn Specock for helping with deliveries. And of course all the many many people who donated gifts/cash/gift cards. We collected over $1200 in monetary donations plus all the wrapped gifts in the pictures. It was really very impressive and the two families were truly grateful for everything they were given!</p> <hr /> <img src="../newsletter/images/mip_roadtrip.jpg" width="300" height="184" alt="MIP Roadtrip"/> <p>MIP has reserved a block of tickets in section 117 to see the Colorado Rockies take on the Chicago Cubs on Saturday, August 8th at 6:10PM at Coors Field in Denver. The price per ticket is $40  a $10 savings over the face value. We are only taking ticket reservations now - no need to come up with any cash until ~ April. All members of the MIP family are invited - so bring the spouse, bring the kiddies, etc. Tickets are going fast - so please email <a href="mailto:Jeffrey.Wilusz@colostate.edu">Jeff Wilusz</a> ASAP if you'd like to reserve some tickets to this 'can't-be-missed' Departmental outing.</p> <hr/> <p class="bluelg">Reading MIPnews: Something to do to pass the time between hockey games</p> <img src="../newsletter/photos/hockeyvets.jpg" width="300" height="228" alt=""/> <p>Pictured above is David Gardiner and Chuck Halsey, the &quot;MIP faculty hockey reps&quot; at the most recent Faculty vs. Student hockey game held December 13, 2008. Final Score; Students-5, Faculty-4.</p> <p>Throughout the year Faculty and Students of CVMBS schedule informal games whenever they can round up enough participants---three or four times per year. They all chip in to pay for the hour of ice time. According to Emeritus Faculty member, Robert Norrdin, they used to play for the &lsquo;Stanley s Cup&rsquo; which was a &lsquo;cup&rsquo; and jock strap laced between two miniature hockey sticks. </p> <hr/> <img src="../newsletter/images/ribbon-cutting.gif" width="300" height="74" alt="ribbon cutting"/> <img src="../newsletter/photos/glenda-ribboncutting.jpg" width="300" height="328" alt="ice machine"/> <p>Need further proof that the 4th floor of the Micro Bldg is cool?? In case you missed it, there was a ribbon cutting ceremony held on the 4th Floor of Microbiology this month to celebrate the much anticipated new ice machine. Glenda Allen did the honors as a crowd of eager scientists waited nearby with buckets in hand.</p> <hr/> <img src="../newsletter/images/j0286674.gif" width="90" height="119" alt="" /><img src="../newsletter/images/sp-seminar-09.jpg" width="210" height="119" alt="Spring Seminar Series"/> <p>Are you one of the many who can't hear enough about drugs, trafficking and the proverbial man-or-a-mouse question? Then be sure to check out the <a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_faculty.aspx" target="_blank">MIP Dept Spring Seminar Schedule</a>. Seminars are held on Fridays from 9-10am in Path 103. Upcoming outside speakers for the semester include... </p> <ul><li>Allison Elliot - Uganda Virus Research Institute</li> <li>Jan Schnitzer - Sidney Kimmel Cancer Center, San Diego</li> <li>Gerald Feur - Upstate Medical University, SUNY</li> <li>Bert Semler - UC-Irvine</li> </ul> <hr/> <p><img src="../newsletter/images/vdance-09.jpg" class="left" hspace="5" />MIP's very own <strong>Glenda Allen</strong> plays in the <a href="http://www.foothillspopsband.org" target="_blank">Foothills Pops Dance Band</a> band who is hosting its annual Valentine's Day Dance fundraiser.</p> <p class="indentsm"> Foothills Pops Dance Bands<br /> Ballroom Favorites and Big Band Swing Music<br /> Lincoln Center<br /> Saturday, February 14, 7:30 PM<br /> Tickets are available at the Lincoln Center Box Office or at the door.<br /> Call 970-221-6730 to reserve tickets.<br /> Adult: $20, Couples: $35<br /> To reserve a group table contact Janene Willey at 970-686-2999</p> <hr /> <img src="../newsletter/images/newprinters.gif" width="300" height="123" alt="new printers"/><br> <font class="smemp">(just when you learned how to work all of the features of our old copy machine....)</font> <p>The Microbiology and Pathology Facilities have had the network printers and copy machines recently upgraded to multi-function workcentre's. The workcentres provide users with increased capabilities with the option to print, copy, fax and scan from each machine. Service for the machines is provided by an on-campus tech whose contact number is marked on the front of each machine. Please be sure to call with any problems you are experiencing. These machines are not only going to provide users with increased capabilities and quicker, more effective service, but will also save the department in operation costs. Accounting codes have been assigned to each PI Group and User Group. Contact your front desk guru if you need to find out your groups code, or if you need to be assigned a code, contact <a href="mailto:Erin.Napier@Colostate.Edu">Erin Napier</a>.</p> <p>Printer equipment at Foothills is currently being evaluated for cost-savings and the department will be receiving quotes for options to make those facilities operate more smoothly as well.</p> <hr/> <img src="../newsletter/images/asm-fellowships.gif" width="300" height="100"/> <p>The American Society of Microbiology is currently accepting applications for their <strong>Microbiology Undergraduate Research Fellowships.</strong></p> <p>Applications are available at the <a href="http://www.asm.org/Education/index.asp?bid_4322" target="_blank">ASM Application Website</a>. The deadline is February 1, 2009.</p> <p>The goal of this program is to increase the number of historically excluded and underrepresented undergraduate students who wish to, and have demonstrated the ability to pursue graduate careers in microbiology. Students will have the opportunity to conduct full time summer research at their home institution or at a sponsoring U.S. institution with an ASM member, and present research results at the 2010 ASM General Meeting.</p> <p>Last year, MIP undergraduate researchers received 4 of the ~40 of these fellowships awarded by ASM. This was the most of any institution in the country. Congratulations to last year&#8217;s recipients (Danielle Cogswell, Petra Gest, Stephanie Lehman, and Katherine Mladinich) and best of luck to this year&#8217;s applicants. </p> <hr/> <img src="../newsletter/images/crcprops.jpg" width="300" height="100"/> <p> Information is now available on the web at <a href="http://www.cvmbs.colostate.edu/cvmbs/FacultyResource.htm" target="_blank">the CVMBS Website</a>. At this website, you will find the Call for Proposals information letter, as well as the CRC Face Sheet and signature page. Proposal deadline is 5:00pm on <strong>Monday, March 23, 2009</strong>.</p> <hr/> <img src="../newsletter/images/cmb_annual_symp.jpg" alt="cmb annual symposium" /> <p>It is time again for food, fun, drink and a little competition compliments of the CMB Program. Graduate students and postdocs in all of the biological and biomedical sciences at Colorado State University are invited to submit abstracts for the Annual Cell and Molecular Biology and Molecular, Cellular &amp; Integrative Neuroscience poster symposium that will be held on Friday, February 27, 2009 in the North Ballroom of the Lory Student Center. See the <a href="cmb-abstract09.pdf" target="_blank">attached flyer</a> for more details.</p> <hr /> <img src="../newsletter/images/asm-2009-confs.jpg" width="300" height="74"/> <p><strong>The 16th ASM Conference for Undergraduate Educators (ASMCUE)</strong> is scheduled to be held in Fort Collins, May 28-31 2009. Abstract submission deadline is February 20, 2009. More information is available at the <a href="http://www.asmcue.org" target="_blank">ASMCUE Website</a>.</p> <hr/> <img src="../newsletter/images/ug_research_opps.gif" width="300" height="188"/> <p>If you are interested in mentoring a student in your lab for Spring 2009, please contact Susan Deines.</p> <hr/> <img src="../newsletter/images/bldg-proctor.gif" alt="building proctor" /> <p align="center">In case of an emergency or any facility-related issue, it's always important to contact your building proctor. Here's the current list of assigned proctors for the MIP facilities:</p> <ul>AIDL: <li>Kerry Grohman</li> <li>Cynthia Meredith (insectaries)</li> <li>Lisa Anaya (back-up)</li></ul> <ul>IDA: <li>Jeanette Fritzler</li> <li>Lisa Anaya (back-up)</li></ul> <ul>MICROBIOLOGY: <li>Kathy Lassen</li> <li>Dawn Petersen (back-up)</li></ul> <ul>PATHOLOGY: <li>Kathy Lassen</li> <li>Wendy Seay (back-up)</li></ul> <hr /> <img src="../newsletter/images/lablines-new.gif" alt="lab lines" /> <p>Check out the 2008 Fall/Winter Edition of the Diagnostic Laboratory Publication, <a href="lablines-2008-fall-winter.pdf" target="_blank">Lab Lines</a>.</p> <hr /> </p> <div align="center"> <img src="../newsletter/images/dmc_updates.gif" width="300" height="105"/><br/><img src="../newsletter/photos/dmc-jan2009-1.jpg" width="300" height="225" alt="dmc south side"/><br/> The south-facing wall.<br/><br/> <img src="../newsletter/photos/dmc-jan2009-2.jpg" width="300" height="225" alt="dmc west side" /><br/> The west-facing wall.<br/><br/> <img src="../newsletter/photos/dmc-jan2009-3.jpg" width="300" height="218" alt="dmc north side" /> <br/> The north-facing wall.<br/><br/> <img src="../newsletter/photos/dmc-jan2009-4.jpg" width="300" height="213" alt="workers on north side"/><br/> Construction workers on north wall </div> <!-- Begin Last Column --> <td width="35%" valign="top"><div align="center"><img src="../newsletter/images/bits.gif" width="160" height="50"></div> <hr> <div align="center"> <img src="../newsletter/images/quote_o_month.gif" width="238" height="47"> </div> <p align="center"> &quot;Common sense ain't common &quot;</p> <div align="right"><em>Will Rogers ~ </em></div> <hr/> <img src="../newsletter/images/whatisthat.gif" width="300" height="103" alt="What is that?"/> <img src="../newsletter/photos/whatthe.jpg" width="300px" height="335px" alt="" /> <p>Can you identify what the item pictured above is... and where it came from?</p> <p>(Hint: it was discovered by an MIP Pathologist)</p> <ol> <strong>Incorrect guesses received to date: </strong> <li>Something from Dr. Calisher's nose?</li> <li>A lyophilized piece of orange chicken from Panda Express?</li> <li>The mother of all common cold viruses?</li> <a href="mailto:Erin.Napier@Colostate.Edu">Send in</a> your guess TODAY! </ol> <hr/> <div align="center"><img src="../newsletter/images/mipuzzle.gif" width="207" height="42"/><br/> <br/> <a href="mipnews-jan2009-p3.htm" target="_blank">Click Here</a> for the questions to MIPuzzle #38<br/> <a href="mipnews-jan2009-p4.htm" target="_blank">Click Here</a> or the answers to MIPuzzle #38<br/> <img src="../newsletter/images/mipuzzle_38.gif" width="300" height="301"/> </div> <hr/> <div align="center"> <p> <font class="greenlg"> <strong>Who will serve as a role model for our profession&#8217;s youth?</strong></font></p> <p><font size="+1"><strong>Where have all the heroes gone?</strong></font></p> <p><strong>Look no further</strong></p> <p><strong>We proudly present to you Episode 2 of &quot;Captain Justice.&quot;</strong></p> </div> <img src="../newsletter/images/captainj-2.jpg" width="300" height="734" alt="cartoon"/> <p>Art: Brooke Jarvie<br> Concept: Paul Moresco<br> Contributions by: Madeline Anna, Jolie Gallagher, Zarine Garcia, Eric Golike, Katriana Popichak, Brett Rosenberg, Brice Thompson, and many others<br> Thoroughly chagrined role model: Pete Justice</p> <hr> <img src="../newsletter/images/nihappenings.gif" width="286" height="61"/> <ul class="bullpurple"> <li><strong>NIH Shared Instrumentation Grant (SIG) Applications due March 23, 2009 </strong> <p>The SIG program provides a cost-effective mechanism for groups of NIH-supported investigators to obtain commercially-available equipment that costs more than $100,000. Instruments in this price range are typically too expensive to be obtained through a research project grant. The maximum SIG award is $500,000. These grants cover the direct costs of the instruments; the grantee institution must meet costs for maintenance, service contracts, and technical support. Awards are for one year only and are not renewable. Please also note that SIG applications only have a single application deadline per year (March 23rd)&nbsp; and that you must identify three or more major users of the technology who are principal investigators on active NIH awards funded through the P01, R01, U01, R35, R37, DP1, or DP2 mechanisms.&nbsp; For more information, check out the NIH <a href="http://www.ncrr.nih.gov/biomedical_technology/shared_instrumentation/" target="_blank">shared instrumentation website</a>.</p> </li></ul> <ul class="bullpurple"> <li><strong>2009 Changes for NIH Peer Review</strong> <p>Curious about the new 9 point rating system (1 = exceptional;&nbsp; 9 = poor) and the 5 core review criteria (significance, investigator(s), innovation, approach, and environment) to be used at NIH study sections over the next couple of months?&nbsp; Check out the <a href="http://cms.csr.nih.gov/NR/rdonlyres/33F7BDD3-4D29-409E-BE22-47ABBF099CED/18809/PRNJan20091.pdf" target="_blank">Jan issue of NIH Peer Review Notes </a> for more information.</p> </li> </ul> <ul class="bullpurple"> <li><strong>Don t forget  its now two strikes and your out</strong> <p>To rebalance success rates and improve system efficiency, new NIH applications and competing renewal applications that are received for fiscal year 2010 and beyond will only be allowed a single resubmission. The last R01 applications eligible for potential A2 submissions were those submitted for the Oct. 5, 2008/Nov. 5, 2008 dates (or earlier) for non-AIDS research or for Jan. 7, 2009 for AIDS research. </p> </li> </ul> <ul class="bullpurple"> <li><strong>Know thy study sections</strong> <p>Want to make sure that your NIH grant application gets accessed by the most appropriate reviewers?&nbsp; For the full scoop on NIH Internal Review Groups and Study Sections, check out the information at the <a href="http://cms.csr.nih.gov/PeerReviewMeetings/CSRIRGDescriptionNew/" target="_blank"> Center for Scientific Review website</a> Study section names, reviewer rosters and Scientific Review Officers (SROs) can be accessed through this link.</p> </li> </ul> <ul class="bullpurple"> <li><strong>USDA Funding Opportunity on the Horizon</strong> <p>The USDA&rsquo;s CSREES has announced a new Agriculture and Food Research Initiative Funding Opportunity.&nbsp; More information and the formal Request for Applications is expected to be released in early 2009.&nbsp; Check it out at <a href="http://www.csrees.usda.gov/newsroom/news/2008news/12171_afri.html" target="_blank">USDA website</a></p> </li> </ul> <hr /> <div align="center"><font color="#FF0000" size="+1"><strong>New Grant Awards</strong></font></div> <p> <img src="../newsletter/images/bullet2.GIF" hspace="10"><strong>Ramesh Akkina</strong>, &quot;Enhancement of HIV-Specific CD4+T Cell Function by Blockade of the PD-1 Pathway&quot;, UCHSC </p> <p> <img src="../newsletter/images/bullet2.GIF" hspace="10"><strong>Karen Dobos</strong>, &quot;Recognition of Mtb-Infected Cells by CD8+T Lymphocytes&quot;, Oregon Health Sciences University </p> <p> <img src="../newsletter/images/bullet2.GIF" hspace="10"><strong>Brian Foy</strong>, &quot;Endectocides for Controlling Transmission of Mosquito-borne Diseases&quot;, Gates Foundation </p> <p> <img src="../newsletter/images/bullet2.GIF" hspace="10"><strong>John Spencer</strong>, &quot;Serology Assay Development&quot;, University of London </p> <p> <img src="../newsletter/images/bullet2.GIF" hspace="10"><strong>Richard Titus</strong>, &quot;Development of Diagnostic for Rift Valley Fever&quot;, USDA-ARS </p> <p> <img src="../newsletter/images/bullet2.GIF" hspace="10"><strong>Mark Zabel</strong>, &quot;Cell Culture-Based In Vitro Amplification Assay as a Diagnostic Tool for CWD&quot;, Int'l Foundation for Ethical Rsch, Inc </p> <hr/> <!-- Begin 1st Calendar --> <div align="center"><font color="#993333"><strong>JANUARY 2009</strong></font></div> <table width="100%" border="3" style="border-color:#993333" > <tr> <td width="20%">Mon</td> <td width="22%">Tue</td> <td width="18%">Wed</td> <td width="20%">Thur</td> <td width="20%">Fri</td> </tr> <tr valign="top"> <td height="80">&nbsp;</td> <td>&nbsp;</td> <td>&nbsp;</td> <td>1<br><font size="-1">Univ Offices Closed</font></td> <td>2<br><font size="-1">Univ Offices Closed</font></td> </tr> <tr valign="top"> <td height="80">5</td> <td>6<br/></td> <td>7<font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/seminars/seminar_microscopy.htm" target="_blank"></a></font></td> <td>8</td> <td>9</td> </tr> <tr valign="top"> <td height="80">12</td> <td>13<font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/seminars/seminar_gradstudent.htm" target="_blank"></a></font></td> <td>14<font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/seminars/seminar_microscopy.htm" target="_blank"></a></font></td> <td>15</td> <td>16<font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/seminars/seminar_faculty.htm" target="_blank"></a></font></td> </tr> <tr valign="top"> <td height="79">19<br><font size="-1">Univ Offices Closed</font></td> <td>20<br><font size="-1">Spring Semester Classes Begin<br/><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_gradstudent.aspx" target="_blank">Graduate Seminar - 12pm - 103 Path</a></font></td> <td>21<font size="-1">&nbsp;</font></td> <td>22</td> <td>23<font size="-1">&nbsp;</font></td> </tr> <tr valign="top"> <td height="79">26</td> <td>27<br><font size="-1">Faculty Mtg - 3pm - Path 103<br/><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_gradstudent.aspx" target="_blank">Graduate Seminar - 12pm - 103 Path</a></font></td> <td>28</td> <td>29</td> <td>30</td> </tr> </table> <hr/> <!--Begin 2nd Calendar--> <div align="center"><font color="purple"><strong>FEBRUARY 2009</strong></font></div> <table width="100%" border="3" style="border-color:Purple"> <tr> <td width="20%">Mon</td> <td width="22%">Tue</td> <td width="18%">Wed</td> <td width="20%">Thur</td> <td width="20%">Fri</td> </tr> <tr valign="top"> <td height="80">2<br/> <img src="../newsletter/images/groundhog.gif" alt="Groundhog Day"/></td> <td>3</td> <td>4</td> <td>5</td> <td>6<br/><font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_faculty.aspx" target="_blank">Faculty Seminar - 9am - Path 103</a> </font></td> </tr> <tr valign="top"> <td height="80">9</td> <td>10<br> <font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_gradstudent.aspx" target="_blank">Graduate Seminar - 12pm - 103 Path</a></font></td> <td>11<font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/seminars/seminar_microscopy.htm" target="_blank"></a></font></td> <td>12</td> <td>13<br/><font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_faculty.aspx" target="_blank">Faculty Seminar - 9am - Path 103</a> </font></td> </tr> <tr valign="top"> <td height="80">16</td> <td>17<br> <font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_gradstudent.aspx" target="_blank">Graduate Seminar - 12pm - 103 Path</a></font></td> <td>18</td> <td>19<br/><font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_faculty.aspx" target="_blank">Faculty Seminar - 12pm - Path 103</a> </font></td> <td>20<br/><font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_faculty.aspx" target="_blank">Faculty Seminar - 9am - Path 103</a> </font></td> </tr> <tr valign="top"> <td height="79">23</td> <td>24<br> <font size="-1">Faculty Mtg - 3pm - Path 103<br/><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_gradstudent.aspx" target="_blank">Graduate Seminar - 12pm - 103 Path</a></font></td> <td>25<font size="-1">&nbsp;</font></td> <td>26</td> <td>27<br/><font size="-1"><a href="http://www.cvmbs.colostate.edu/mip/Seminars/seminar_faculty.aspx" target="_blank">Faculty Seminar - 9am - Path 103</a> </font></td> </tr> </table> <hr> <p><font size="+1" color="#CC0033">Do you have NEWS or PICTURES you would like to share?</font></p> <p> <a href="mailto:erin.napier@colostate.edu">Send In</a> your ideas or newsworthy items. Contributions make the Newsletter better! </td> </tr> </table> <!-- End Columns --> <!-- Begin Footer --> <table id="footer" width="100%" border="1" cellspacing="0" cellpadding="2" bgcolor="#CCCCCC"> <tr> <td>MIP Newsletter Volume 6, Issue 1, January 2009 </td> <td align="right"><a href="../Default.aspx">MIP Home</a> &#149; <a href="http://www.cvmbs.colostate.edu/">CVMBS Home</a> &#149; <a href="http://welcome.colostate.edu/">CSU Home</a></td> </tr> </table> <script type="text/javascript"> var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E% 3C/script%3E")); </script> <script type="text/javascript"> try { var pageTracker = _gat._getTracker("UA-3412138-1"); pageTracker._trackPageview(); } catch(err) {}</script> </body> </html>