Vol. 10 | No. 8
Congratulations to Dr. Barry Beaty for receiving the Harry Hoogstraal Medal at the American Society of Tropical Medicine and Hygiene annual meeting. This is an honor for Outstanding Achievement in Medical Entomology. Dr. Beaty was also elected a Fellow of the ASTMH (which by the way, is not to be confused with ASTHMA – although all of these awards can surely take one’s breath away…..)
Each semester MIP faculty recognizes an Outstanding Graduating Senior for academic excellence and or contribution to the department or the community. Jonathan Seaman was recognized with the award at the December commencement ceremony.
MIP Graduate Students who received their Degrees on December 20...
Alana Garner, MS
MIP Undergraduate Students who received their B.S. Degrees on December 21...
Dr. Richard Titus, former Professor of MIP, will be rembered for his generous spirit and commitment to education. Dr. Titus bequeathed a substantial gift to the Poudre Valley Hospital Foundation, which was used to fund 10 nursing scholarships.
Congratulations to Shannon McLeland for passing the ACVP certifying examination. Eligibility for the examination is based on the candidate's satisfactory standing in the profession; graduating from a recognized college or school of veterinary medicine or being legally qualified to practice veterinary medicine; and completing training adequate to acquire knowledge sufficient to assume responsibility for the broad spectrum of assessment and interpretation of specimens, problems and situations encountered by veterinary pathologists.
The annual American College of Veterinary Pathologists meeting was held in Montreal, QC, Canada November 16-20, 2013.
Dr. Chuck Halsey received the First Place Young Investigator Award. Chuck received the award for his poster in the Experimental Disease and Industrial and Toxicologic Pathology category.
Dr. Elijah Edmondson received the Resident Travel award and received the Second Place Young Investigator Award for his poster in the Experimental Disease and Industrial and Toxicologic Pathology category.
Leprosy Research in Brazil
In the last three months Dr. John Spencer has spent 13 weeks traveling in Brazil diagnosing new cases of Leprosy. On his latest trip, a team of 22, including leprologists, physiotherapists, nurses, and technicians visited the town of Breves on Marajo Island. The only way to get there with three vehicles and the necessary equipment was a fifteen hour boat ride up the Amazon River. The team bled and examined over 650 schoolchildren and their household contacts. They diagnosed 62 new cases, half of which were in children. That is about 10%, which is over 600 times the national average for Brazil. Dr. Spencer submitted a video, produced by Erin Napier, featuring his Leprosy work in Brazil for the Global Video Challenge, a competition to recognize how microbiology is changing the world. Check out the video by clicking the link below.
Congratulations to Stephanie Moon, Mike Barnhart and the Wilusz2 lab for having their recent Cell Reports paper entitled "Changes in Cellular mRNA Stability, Splicing, and Polyadenylation through HuR Protein Sequestration by a Cytoplasmic RNA Virus” recommended by the Faculty of 1000.
Epigenetic Dominance of Prion Conformers
Eri Saijo, Hae-Eun Kang, Jifeng Bian, Kristi Bowling, Shawn Browning, Sehun Kim, Nora Hunter and Glenn Telling
PLOS Pathogens, 9(1): e1003692. Doi:10.1371/journal.ppat.1003692
How does Santa decide if a prion is being naughty or nice? Well I’m not ‘telling’ - just read Glenn’s lab’s latest paper for at least part of the answer…..
MIP Publications December 2013
Shanley CA, Ireton GC, Baldwin SL, Coler RN, Reed SG, Basaraba RJ, Orme IM. Therapeutic vaccination against relevant high virulence clinical isolates of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2013 Sep 7. doi:pii: S1472-9792(13)00159-5.
De Groote MA, Johnson L, Podell B, Brooks E, Basaraba R, Gonzalez-Juarrero M. GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus. J Antimicrob Chemother. 2013 Nov 11. [Epub ahead of print]
Muñoz Mde L, Limón-Camacho G, Tovar R, Diaz-Badillo A, Mendoza-Hernández G, Black WC 4th. Proteomic Identification of Dengue Virus Binding Proteins in Aedes aegypti Mosquitoes and Aedes albopictus Cells. Biomed Res Int. 2013;2013:875958.
Saavedra-Rodriguez K, Strode C, Flores AE, Garcia-Luna S, Reyes-Solis G, Ranson H, Hemingway J, Black WC 4th. Differential transcription profiles in Aedes aegypti detoxification genes after temephos selection. Insect Mol Biol. 2013 Dec 3. doi: 10.1111/imb.12073. [Epub ahead of print]
Calvert AE, Dixon KL, Delorey MJ, Blair CD, Roehrig JT. Development of a small animal peripheral challenge model of Japanese encephalitis virus using interferon deficient AG129 mice and the SA14-14-2 vaccine virus strain. Vaccine. 2013 Nov 17. doi:pii: S0264-410X(13)01533-8. 10.1016/j.vaccine.2013.11.016. [Epub ahead of print]
Hoon-Hanks LL, Regan D, Dubey JP, Carol Porter M, Duncan CG. Hepatic neosporosis in a dog treated for pemphigus foliaceus. J Vet Diagn Invest. 2013 Nov;25(6):807-10. doi: 10.1177/1040638713507257.
Campbell CL, Harrison T, Hess AM, Ebel GD. MicroRNA levels are modulated in Aedes aegypti after exposure to Dengue-2. Insect Mol Biol. 2013 Nov 15. doi: 10.1111/imb.12070. [Epub ahead of print]
Deardorff ER, Nofchissey RA, Cook JA, Hope AG, Tsvetkova A, Talbot SL, Ebel GD. Powassan virus in mammals, alaska and new Mexico, USA, and Russia, 2004-2007. Emerg Infect Dis. 2013 Dec;19(12):2012-6. doi: 10.3201/eid1912.130319.
Gonzalez-Juarrero M, Mima N, Trunck LA, Schweizer HP, Bowen RA, Dascher K, Mwangi W, Eckstein TM. Polar Lipids of Burkholderia pseudomallei Induce Different Host Immune Responses. PLoS One. 2013 Nov 18;8(11):e80368. doi: 10.1371/journal.pone.0080368
Newkirk KM, Hendrix DV, Anis EA, Rohrbach BW, Ehrhart EJ, Lyons JA, Kania SA. Detection of papillomavirus in equine periocular and penile squamous cell carcinoma. J Vet Diagn Invest. 2013 Dec 9. [Epub ahead of print]
Puttlitz C, Gadomski BC, McGilvray K, Easley J, Palmer R, Ehrhart EJ, Haussler K, Browning R, Santoni B. A Translational Bone Model of Simulated Microgravity. J Biomech Eng. 2013 Oct 1. doi: 10.1115/1.4025854. [Epub ahead of print]
Minhas FU, Geiss BJ, Ben-Hur A. PAIRpred: Partner-specific prediction of interacting residues from sequence and structure. Proteins. 2013 Nov 16. doi: 10.1002/prot.24479. [Epub ahead of print]
Elder AM, Henderson DM, Nalls AV, Wilham JM, Caughey BW, Hoover EA, Kincaid AE, Bartz JC, Mathiason CK. In Vitro Detection of prionemia in TSE-Infected Cervids and Hamsters. PLoS One. 2013 Nov 1;8(11):e80203. doi: 10.1371/journal.pone.0080203.
Cayabyab MJ, Qin L, Kashino SS, Izzo A, Campos-Neto A. An unbiased peptide-wide discovery approach to select Mycobacterium tuberculosis antigens that target CD8+ T cell response during infection. Vaccine. 2013 Oct 1;31(42):4834-40.
Deshayes C, Angala SK, Marion E, Brandli I, Babonneau J, Preisser L, Eyangoh S, Delneste Y, Legras P, De Chastellier C, Stinear TP, Jackson M, Marsollier L. Regulation of Mycolactone, the Mycobacterium ulcerans Toxin, Depends on Nutrient Source. PLoS Negl Trop Dis. 2013 Nov 14;7(11):e2502. doi: 10.1371/journal.pntd.0002502.
Favrot L, Grzegorzewicz AE, Lajiness DH, Marvin RK, Boucau J, Isailovic D, Jackson M, Ronning DR. Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun. 2013 Nov 6;4:2748. doi: 10.1038/ncomms3748.
Haley NJ, Van de Motter A, Carver S, Henderson D, Davenport K, Seelig DM, Mathiason C, Hoover E. Prion-seeding activity in cerebrospinal fluid of deer with chronic wasting disease. PLoS One. 2013 Nov 25;8(11):e81488. doi: 10.1371/journal.pone.0081488.
Phillips AT, Schountz T, Toth AM, Rico AB, Jarvis DL, Powers AM, Olson KE. LIPOSOME-ANTIGEN-NUCLEIC ACID COMPLEXES PROTECT MICE FROM LETHAL CHALLENGE WITH WESTERN AND EASTERN EQUINE ENCEPHALITIS VIRUSES. J Virol. 2013 Nov 20. [Epub ahead of print]
Obregón-Henao A, Henao-Tamayo M, Orme IM, Ordway DJ. Gr1(int)CD11b(+) Myeloid-Derived Suppressor Cells in Mycobacterium tuberculosis Infection. PLoS One. 2013 Nov 1;8(11):e80669. doi: 10.1371/journal.pone.0080669.
O'Hara S, Wang K, Slayden RA, Schenkel AR, Huber G, O'Hern CS, Shattuck MD, Kirby M. Iterative Feature Removal Yields Highly Discriminative Pathways. BMC Genomics. 2013 Nov 25;14(1):832. [Epub ahead of print]
Cummings JE, Kingry LC, Rholl DA, Schweizer HP, Tonge PJ, Slayden RA. The Burkholderia pseudomallei enoyl-ACP reductase FabI1 is essential for in vivo growth and is the target of a novel chemotherapeutic with efficacy. Antimicrob Agents Chemother. 2013 Nov 25. [Epub ahead of print]
Awasthi D, Kumar K, Knudson SE, Slayden RA, Ojima I. SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents. J Med Chem. 2013 Nov 23. [Epub ahead of print]
Ramirez MV, Dawson CC, Crew R, England K, Slayden RA. MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein. BMC Microbiol. 2013 Oct 31;13(1):240. [Epub ahead of print]
Nadler SA, Lyons ET, Pagan C, Hyman D, Lewis EE, Beckmen K, Bell CM, Castinel A, Delong RL, Duignan PJ, Farinpour C, Huntington KB, Kuiken T, Morgades D, Naem S, Norman R, Parker C, Ramos P, Spraker TR, Berón-Vera B. Molecular systematics of pinniped hookworms (Nematoda: Uncinaria): species delimitation, host associations and host-induced morphometric variation. Int J Parasitol. 2013 Dec;43(14):1119-32.
Vickery CM, Lockey R, Holder TM, Thorne L, Beck KE, Wilson C, Denyer M, Sheehan J, Marsh S, Webb PR, Dexter I, Norman A, Popescu E, Schneider A, Holden P, Griffiths PC, Plater JM, Dagleish MP, Martin S, Telling GC, Simmons MM, Spiropoulos J. Assessing the susceptibility of transgenic mice over-expressing deer prion protein to bovine spongiform encephalopathy. J Virol. 2013 Nov 20. [Epub ahead of print]
Saijo E, Kang HE, Bian J, Bowling KG, Browning S, Kim S, Hunter N, Telling GC. Epigenetic dominance of prion conformers. PLoS Pathog. 2013 Oct;9(10):e1003692.
Flatland B, Freeman KP, Vap LM, Harr KE. ASVCP guidelines: quality assurance for point-of-care testing in veterinary medicine. Vet Clin Pathol. 2013 Dec;42(4):405-23. doi: 10.1111/vcp.12099.
Barnhart MD, Moon SL, Emch AW, Wilusz CJ, Wilusz J. Changes in Cellular mRNA Stability, Splicing, and Polyadenylation through HuR Protein Sequestration by a Cytoplasmic RNA Virus. Cell Rep. 2013 Nov 27;5(4):909-17.
Best Wishes Erin!
As we're sure you know by now, Erin Napier has accepted a position as the Web Administrator for the College of Veterinary Medicine and Biomedical Sciences. Erin worked in MIP for 13 years - and on the MIP newsletter for over 9 years - and will be greatly missed. She was known for her infectious laugh, great sense of humor and uncanny ability to get things done. We wish her nothing but the very best in her new position. Check out the photos from her farewell reception.
Every December the MIP family demonstrates the true meaning of the holiday season by participating in The Salvation Army's Adopt-A-Family program. This year was no different. Gifts for three local families were collected and distributed by December 10th. THANK YOU to everyone that participated, especially Susan Reuth, Carol Wilusz, Cathy Griffin and Tach Costello.
SAVE THE DATE!
The 15th Annual CVMBS Research Day will be held January 25, 2014 at the Hilton Fort Collins. Come on out and check out the record 59 posters and presentations from the MIP Dept!!! For more information please visit the CVMBS Research Day webpage or contact Dr. Brad Borlee at Brad.Borlee@colostate.edu.
8th Annual Exhibition
This exhibition showcases the creative energies of students, faculty, and staff at Colorado State University and exemplifies the common ties between scientific inquiry and artistic practice.
Registration Now Open! (but closes December 31 so hurry!)
Countdown to ASV2014
Next June, we’ll be hosting the large (1,200+ participant) 33rd Annual meeting of the American Society for Virology right here on the CSU campus! Please mark your calendars for this special, can’t-be-missed event. Also – we’ll be looking for numerous (50+) volunteers to help with numerous AV/customer service aspects of this event – so please consider helping us out when asked.
This is a golden opportunity to showcase MIP’s infectious disease expertise and high-quality environment to a large international group of experts in the field. We’ll definitely need the collective help of the MIP community to make this a truly special meeting. For further information on the event, please contact Jeff Wilusz (local lead organizer) at email@example.com.
The American Society for Microbiology is currently accepting applications for their ASM Undergraduate Research Fellowship
The deadline is February 1st!
The American Heart Association and the American Stroke Association undergraduate student research program is designed to inspire promising students from all disciplines, including women and members of minority groups underrepresented in the sciences, to consider research careers while supporting the highest quality scientific investigation broadly related to cardiovascular disease and stroke. The research opportunity will allow studentst to work for 10 weeks with a faculty/staff member on any project broadly related to cardiovascular function and diseases, stroke, or to associated basic science, clinical, bioengineering/biotechnology and public health problems.
To Apply Go To www.heart.org!
Look for Healthcare/Research Tab, Click on Research, then on Funding Opportunities.
The deadline is January 17th!
Friday, November 22 marked the Annual MIP Thanksgiving Potluck. Faculty, staff and students enjoyed a relaxing lunch with all the traditional favorites. Be sure to check out the Thanksgiving Photo Gallery.
Congrats to Dr. Brian Foy, whose FC2 soccer team (pictured) recently won the Over-40's league of the Fort Collins Soccer Club, after beating arch enemy Ian Orme's Vintage Cork team in an extra time penalty shoot out in the play-off semi finals. Ian would like to note however; that his team was the only team, to beat the only team, that beat FC2 in the regular season. So there...
The Colorado Combined Campaign is one opportunity for CSU faculty and staff to support their favorite community charities via payroll deduction. If you are interested in participating you will need to do so by December 31. You can either donate online or with the paper pledge form you should have received in the mail. For more information, visit the Colorado Combined Campaign website.
Halloween was a scary good time! Check out the photo gallery.
Happy Holidays and Best Wishes for a Mean ‘14
New Grant Awards
Richard Slayden, "Overcoming Resistance by the Application of Born to Ribosomal Inhibitors", Anacor Pharmaceuticals, Inc.
Barbara Powers, "NAHLN: CO Animal Diagnostic Laboratory 2012-2013", USDA-NIFA
Ian Orme, "Environmental Mycobacteria and BCG Interference", NIH-NIAID
Anne Lenaerts, "Advanced in vivo Compound Evaluation Program against M. tuberculosis by Anacor Pharmaceuticals", Anacor Pharmaceuticals, Inc.
Kristy Pabilonia, "Long-Term Antibody Persistence to Avian Influenza Virus in Mallards", USDA-APHIS
Kristy Pabilonia, "National Wildlife Disease Tissue Archive ", USDA-APHIS
Angelo Izzo, "Testing of Mutant Mycobacteria in Established Advanced Small Animal Models ", NIH-NIAID
Steve Dow, "Evaluation of Novel Immune Modulatory Drugs ", Merck & Co., Inc.
Steve Dow, "Monocyte Targeted Immunotherapy for Cancer ", Charles R. Shipley, Jr., Foundation, Inc
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