The Laboratory for Immunotherapy studies the role of innate immunity in cancer, infectious diseases, vaccine adjuvant design and function, and in chronic inflammatory disorders. The Cancer Group in the laboratory is investigating the role of myeloid suppressor cells in tumor growth and how depletion of these cells may restore tumor immunity and enhance the effectiveness of tumor vaccines. In the Infectious Disease Group, laboratory members are investigating the immune response to Burkholderia pseudomallei, how this organism infects the lungs and GI tract, and how immunotherapy may enhance antibiotic activity. They are also investigating new vaccine approaches to the treatment of chronic staphylococcal infection. The Stem Cell Group is investigating the immune modulatory properties of mesenchymal stem cells and the potential for clinical use of stem cell therapy for treatment of chronic kidney disease and asthma.