Jonathan O. Carlson
Professor

Phone: 491-7840
Fax: 491-1815
Email: Jonathan.Carlson@colostate.edu
Office: B408 Microbiology Building
Lab: B430 Microbiology Building

Degrees

B.S., Colorado State University
Ph.D., University of California, Berkeley

Research Interests

Molecular Biology of Animal Viruses

The projects in my laboratory involve the genetics, gene expression, structure and pathogenesis of several kinds of animal viruses:

A major effort in my laboratory is directed at development of mosquito densonucleosis viruses as tools for fighting mosquito-borne diseases. These are parvoviruses of mosquitoes, and they show promise for both mosquito control applications and as vectors for introducing genes of interest into mosquitoes.

A second project involves the jaagsiekte sheep retrovirus (JSRV). This virus causes lung tumors in sheep and we are interested in elucidating the mechanisms of oncogenesis.

Selected Publications

Pub Med for Carlson JO.

Carlson, J., B. Afanasiev and E. Suchman. 2000. Densoviruses as transducing vectors for insects. In: Insect Transgenesis: Methods and Applications (A. Handler and A James, Eds.) CRC Press pp139-159.

T. W. Ward, M. W. Kimmick, B. N. Afanasiev and J. O. Carlson, 2001, Characterization of the structural gene promoter of Aedes aegypti densovirus, Journal of Virology 75: 1325-1331.

J. C. DeMartini, J. V. Bishop, T. E. Allen, F. A. Jassim, J. M. Sharp, M. De Las Heras, D. R. Voelker and J. O. Carlson, 2001, The jaagsiekte sheep retrovirus clone, JSRVJS7, derived from the JS7 lung tumor cell line, induces ovine pulmonary carcinoma and is integrated into the surfactant protein A gene. Journal of Virology 75: 4239-4246.

T.A. Miura, J.O. Carlson, B.J. Beaty, R.A. Bowen, and K.E. Olson, 2001, Expression of Human MxA Protein in Mosquito Cells Interferes with LaCrosse Virus Replication. Journal of Virology 75: 3001-3003.

Z. N. Adelman, C. D. Blair, J. O. Carlson, B. J. Beaty and K. E. Olson, 2001, Sindbis virus-induced silencing of dengue viruses in mosquitoes. Insect Molecular Biology 10: 265-274.

Ward, T.W., M.S. Jenkins, B.N. Afanasiev, M. Edwards, B.A. Duda, E. Suchman, M. Jacobs-Lorena, B.J. Beaty and J.O. Carlson, 2001, Aedes aegypti transducing densovirus pathogenesis and expression in Aedes aegypti and Anopheles gambiae larvae. Insect Molecular Biology 10: 397-406.

Afanasiev, B.N. and J. Carlson, 2001, Brevidensovirus in The Springer Index of Viruses (C.A. Tidona and G. Darai, Eds.) Springer, Berlin, pp690-694.

Han, Binbing, J.O. Carlson, S.M. Powers, and S. R. Wickramasinghe, 2002, Enhanced virus removal by flocculation and microfiltration. Biotechnology and Bioprecess Engineering 7: 6-9.

Adelman, Z.N. I. Sanchez-Vargas, E.A. Travanty, J.O. Carlson, B.J. Beaty, C.D. Blair, and K.E. Olson, 2002, RNA Silencing of Dengue Virus Type 2 Replication in Transformed C6/36 Mosquito Cells Transcribing an Inverted-Repeat RNA Derived from the Virus Genome. J. Virol. 2002 76: 12925-12933.

Allen, T. E., K. J. Sherrill, S.M. Crispell, M.R. Perrott, J.O. Carlson and J.C. DeMartini. 2002. The jaagsiekte retrovirus envelope gene induces transformation of the avian embryo fibroblast cell line DF-1 but does not require a conserved SH2 binding domain. J. Gen. Virol. 83: 2733-2742.

DeMartini, J.C., J.O. Carlson, C. Leroux, T. Spencer, and M. Palmarini, 2003, Endogenous retroviruses related to jaagsiekte sheep retrovirus. Current Topics in Microbiology and Immunology, Jaagsiekte Sheep Retrovirus and Lung Cancer. H. Fan (Ed.), Springer-Verlag, Germany, pp.117-137.

Carlson, J., M. Lyon, J. Bishop, A. Vaiman, E. Cribiu, J.-F. Mornex, S. Brown, D. Knudson, J. DeMartini and C. Leroux . 2003 Chromosomal Distribution of Endogenous Jaagsiekte Sheep Retrovirus Proviral Sequences in the Sheep Genome. Journal of Virology 77: 9662-9668.