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WHAT'S NEW IN ERHS

ERHS graduate students discuss a problem in graphing

Health Physics Course Receives Continuing Education Award

The nation's first online-delivered Certified Health Physics (CHP) course earned an honorable mention award (second place) from the University Continuing Education Association in a September conference of the UCEA Great Plains Region.

The course was taught by Dr. Tom Johnson, Assistant Professor at Colorado State University. The CSU student branch of the Health Physics Society supported the course and graduate students delivered many of the lectures and presentations in the online course. The CHP review course was recognized for its innovative method of delivery; the course was taught over 17 weeks, with a two hour lecture streamed via the Internet each week and an iPod download of each presentation. Online interaction was available both live during the class and throughout each week following the presentation. More than 50 distance participants, mostly industry professionals, were spread across the US and the world making this an international course.

CSU graduate students were responsible for preparing and teaching major portions of the class. Additionally, the CSU students served as mentors to distance students taking the class, tracking the progress of each person through the course. Participants took Part One quizzes on specific topics each week, answering a total of more than 500 questions, all of which were graded online. Participants were also able to also take subject specific Part Two exams and examine detailed answers for each question. The CSU graduate students found that the review class helped to reinforce health physics concepts and provided them a chance to use the skills they learned in their coursework. Reviews from participants were uniformly positive, with the course generating a waiting list for the next offering.

ACGIH® announces results of 2008 election for the Board of Directors.

ACGIH® members elected Stephen J. Reynolds, PhD, CIH, to the position of Vice Chair-Elect. He will begin his four-year term on January 1, 2008. Dr. Reynolds is Professor and Head of the Occupational and Environmental Health Section, Department of Environmental and Radiological Health Sciences, at Colorado State University. Dr. Reynolds joined ACGIH® in 1995.
ACGIH® is a member-based organization that advances occupational and environmental health. ACGIH® is one of the industry's leading publications resources, with approximately 400 titles relative to occupational and environmental health and safety, including the renowned TLVs® and BEIs®. For more information, visit the ACGIH® website at www.acgih.org.

Health Physics M.S. program accredited

Colorado State's Health Physics M.S. program has received full and unconditional accreditation from ABET/Applied Sciences Accreditation Commission. CSU's Health Physics graduate program is only the 5th in the U.S. to be accredited. Please congratulate our team: Dr. Tom Johnson and the rest of the Health Physics faculty, our External Advisory Board and our administrative coordinator, Ms. Julie Asmus, for this outstanding achievement, which will add significant value to the M.S. degrees awarded to our students.

Toxicology faculty members win a very competitive major grant from the EPA.

Colorado State University will receive $748,582 in grant funding from the U.S. Environmental Protection Agency to develop a software tool to interpret biomarkers of human exposure to pesticides/insecticides.
Participating CSU scientists are:
Brad Reisfeld, Principal Investigator, College of Engineering's Department of Chemical and Biological Engineering
Michael Lyons, College of Veterinary Medicine and Biomedical Sciences' Department of Environmental and Radiological Health Sciences
Arthur Mayeno, College of Veterinary Medicine and Biomedical Sciences' Department of Environmental and Radiological Health Sciences
Raymond Yang, College of Veterinary Medicine and Biomedical Sciences' Department of Environmental and Radiological Health Sciences

With this grant to CSU, EPA is helping solve the mystery of the connection between measured biomarkers and chemical exposures. A biomarker is a substance, structure, or process that can be measured in biological samples, such as blood or urine, to indicate exposure, susceptibility or health effects. Examples of biomarkers include lead levels in blood or pesticide metabolite levels in urine.
These types of biomarkers indicate exposure to specific compounds. In many cases, biomarkers can be measured analytically, but it is not always clear what the levels mean in terms of how much exposure occurred or what amount of the chemical reaches a place in the body where it could possibly cause a health effect (dose).
CSU will work with Mississippi State University on this research project. This grant is one of five that EPA is awarding in response to a request for applications called "Interpretation of Biomarkers Using Physiologically Based Pharmacokinetic Modeling." The EPA Science to Achieve Results (STAR) research grant will be used to develop a computer model that will be able to predict what biomarker levels mean in terms of human exposure and dose.
The researchers will use chlorpyrifos and diazinon, two organophosphate (OP) insecticides, as the initial test compounds. The research results will allow scientists and risk assessors to understand more about the meaning of biomarkers resulting from exposure to OP insecticides.

NIOSH Education & Research Center Comes to Colorado

The CDC/National Institute for Occupational Safety and Health (NIOSH) approved funding for the NIOSH Mountains and Plains Education and Research Center.

CSPHI shares the excitement as this new NIOSH Education and Research Center is one of the first concrete examples of inter-institutional collaboration that will become a part of the proposed school of public health.

Under the leadership of Center Director Dr. Lee Newman (UCDHSC) and Deputy Director Dr. Stephen Reynolds (CSU), the Center will expand existing training programs in Occupational Medicine, Industrial Hygiene, Ergonomics, and Health Physics.

It will also fund the launch of a new graduate program in Occupational Health Psychology. The Center will expand occupational health education in the region through continuing education offerings; community outreach; pilot research grants; and activities designed to improve the region's diversity of occupational health professionals.

Each of these new programs will be connected to the environmental and occupational health education and research of the proposed Colorado School of Public Health.

"It is a tremendously exciting moment for occupational health education and outreach in a region that faces significant new challenges in protecting the health of workers," stated Dr. Newman.

Project Directors are:

  • Lee Newman - Director (UCHSC)
  • Steve Reynolds - Deputy Director (CSU)
  • Bibi Gottsschall - Occupational Medicine (UCHSC)
  • Steve Reynolds - Industrial Hygiene (CSU)
  • Tom Borak - Health Physics (CSU)
  • John Rosecrance - Ergonomics (CSU)
  • Peter Chen - Occupational Health Psychology (CSU)
  • Cindy Becnel - Outreach (UCHSC)
  • Karen Mulloy - Continuing Education (Denver Health)
  • Cheryl Asmus - Psychology (CSU)


  • Faculty and staff from UCDHSC, CSU, National Jewish, Denver Health and the University of New Mexico Health Sciences Center all participated in bringing this award to the Rocky Mountain Region. The NIOSH Mountains and Plains Education and Research Center will be one of 17 centers throughout the country.

    Post Doctoral Fellow Awarded NIH Funding to Study Parkinsons Disease
    David Carbone, Ph.D., post doctoral fellow in the Toxicology section of Environmental and Radiological Health Sciences, recently received a grant award from NIH/HINDS. The title of his research proposal was MPTP and astrogliosis: molecular regulation of constitutive NOS by PPAR-gamma.
    While the etiology of Parkinsons disease (PD) remains elusive, perturbations in the activity of astrocytes, a type of supporting cell in the nervous system, as well as induction of the enzyme neuronal nitric oxide synthase (NOS1), have emerged as key components of both human PD and the chemical 1-methyl-4-phenyl-1,2,3,6-tetrahydropyradine (MPTP) model of the disease. Preliminary data generated by our laboratory have demonstrated selective induction of NOS1 in primary astrocytes exposed to a treatment paradigm consisting of MPTP and the inflammatory cytokines TNF-alpha and IFN-gamma, designed to simulate an early stage inflammatory event such as that which likely occurs in PD. Furthermore, our data have demonstrated suppression of this enzyme through modulation of the nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-gamma) using a novel high-affinity ligand. It is therefore the objective of this research to characterize the molecular mechanisms by which NOS1 is selectively induced in astrocytes, as well as the suppression of this enzyme through modulation of the nuclear receptor PPAR-gamma. Because PD is currently incurable, it is anticipated that this research will reveal novel targets for more effectively treating PD.

    FACULTY MEMBER SELECTED FOR FULBRIGHT SENIOR SPECIALISTS GRANT
    Dr. Stephen Reynolds has been selected by the J. William Fulbright Foreign Scholarship Board (the Board), the Bureau of Education and Cultural Affairs of the Department of State (the Department), and the Council for International Exchange of Scholars (CIES) for a Fulbright Senior Specialists Grant in Public/Global Health.
    The specialist program's main emphasis is on curriculum development, needs assessments, surveys, institutional or programmatic research, and teacher-training activities at the tertiary level. The purpose is to lecture in environmental health, health risk assessment and epidemiology to graduate/postgraduate students and young faculty as well as to conduct curriculum assessment and provide advice on improvement areas.

    Dr. Reynolds will travel to the Yerevan State Medical University, Armenia, for a 14 day visit with former University of Iowa post-doctoral associate Artashes Tatevosyan, M.D., now a faculty member of the Armenian university. Together they will address curriculum development and teaching on environmental and occupational medicine, plus research in agricultural health.

    THE AMERICAN PARKINSONS' DISEASE ASSOCIATION AWARDS GRANTS TO DR. MARIE LEGARE AND DR. RONALD TJALKENS

    Dr. Legare's Title and Abstract

    Effects of DJ-1 Mutation on Astroglial Cellular Function
    Recently discovered mutations in DJ-1 are associated with development of familial autosomal recessive early-onset PD. To study the physiological role of DJ-1 in astrocytes, a DJ-1 knockout mouse was developed and functional gene inactivation was confirmed. Our study aims to characterize basal astroglial homeostasis as well as response to environmentally-relevant chemical exposure in normal cells and those harboring mutated DJ-1. Our preliminary experiments reveal altered IP3-induced astrocytic intracellular calcium as well as morphometric differences, indicating normal astrocytic homeostasis is altered by the DJ-1 mutation. Our central hypothesis is that mutation of DJ-1 disrupts astroglial cellular function, increasing their susceptibility to toxic insults, underscoring a critical linkage between disruption of astrocytic cell function and neuronal death.

    Dr. Tjalkens' Title and Abstract

    Targeting glia in Parkinsons disease: modulation of astrocyte inflammatory phenotype by orphan nuclear receptors.
    Perturbed astrocyte function is recognized as a contributing factor to the neuronal death characteristic of Parkinson's disease (PD). Using a treatment paradigm mimicking the early stages of PD, our laboratory has recently discovered selective induction of neuronal nitric oxide synthase (NOS1) in astrocytes, rather than the inducible variant, NOS2. These data implicate induction of astrocyte NOS1 as a subtle yet critical event in the progression of PD, occurring prior to the onset of astrogliosis. This notion is strongly supported by literature reports describing postmortem findings in humans as well as by rodent NOS1 knockout studies. Our laboratory has also observed suppression of astrocyte NOS1 induction through ligand-mediated modulation of the orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-?) using a novel high-affinity diindolylmethane (DIM) analogue. The present studies are thus designed to examine the neuroprotective efficacy of this novel agonist, as well as identify a mechanism behind PPAR-?-mediated NOS1 suppression.

    Follow this link to previous issues of department newsletter, The Emitter
    Follow this link to recent issues of the CVMBS magazine, Insight.

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