Raymond S. H. Yang, Ph.D.
Professor
Phone: (970) 491-5652
Fax: (970) 491-7569
Email:
Raymond.Yang@colostate.edu
Office: 137 A Physiology Building
Degrees
Ph.D., Toxicology, Entomology, North Carolina State University
M.S., Toxicology, Entomology, North Carolina State University
B.S., Biology, National Taiwan University
Current CV in PDF format
Research Interests
Dr. Yang's research interests are Physiologically Based Pharmacokinetic/Pharmacodynamic
(PBPK/PD) Modeling, Biologically Based Dose Response (BBDR) Modeling,
Reaction Network Modeling, Chemical Mixture Toxicology, Toxicologic Interactions,
Carcinogenesis/ Neuro-Developmental Toxicology, Risk Assessment.
Dr. Yang has had extensive experience in toxicology in industry (Mellon Institute/Union Carbide
Corporation), government (National Institute of Environmental Health
Sciences/National Toxicology Program), and academia (Cornell
University, Albany Medical College, CSU). He established and
developed the Quantitative and Computational Toxicology Group at CSU. Dr. Yang believes that the application of
computer to toxicology, just as computer applications in our life,
will become more and more prevalent. Thus, the development of
Virtual Cells, Virtual Organs, Virtual Animals, and Virtual
Humans is only the matter of time. In that sense, the CSU Quantitative and Computational Toxicology Group
is at the beginning of establishing a new form of "bioinformatics" in that they are building the pieces
of the puzzle on the complex biological processes involved in toxicology.
Selected Publications
Thomas, R. S., Conolly, R.B., Gustafson, D.L., Long, M.E., Benjamin, S.A., and
Yang, R. S. H. 2000. A physiologically-based pharmacodynamic analysis of hepatic
foci within a medium-term liver foci bioassay using pentachlorobenzene as a promotor and diethylnitrosamine
as an initiator. Toxicol. Appl. Pharmacol. 166:128-137.
Ou, Y.C., Connolly, R.B., Thomas, R.S., Xu, Y., Andersen, M.E., Chubb, L., Pitot, H.C.,
and Yang, R. S. H. 2001. A clonal growth model: Time-course simulations of liver foci
growth following penta or hexachlorobenzene treatment in a medium-term bioassay. Cancer Res. 61: 1879-89.
Liao, K.H., Gustafson, D.L., Fox, M.H., Chubb, L.S., Reardon, K.F., and Yang, R.S.H. 2001. A
biologically-based model of growth and senescence of Syrian Hamster Embryo (SHE) cells after exposure to
arsenic. Environ. Health Perspect. 109:1207-1213.
Lee, S. K., Ou, Y. C., and Yang, R. S. H. 2002. Comparison of Pharmacokinetic Interactions and
Physiologically-based Pharmacokinetic Modeling of PCB 153 and PCB 126 in Non-pregnant, Lactating Mice and
Suckling Pups Toxicol. Sci. 65:26-34.
Dobrev, I., Andersen, M. E., and Yang, R. S. H. 2002. In silico toxicology: Simulating interaction
thresholds for human exposure to mixtures of trichloroethylene, tetrachloroethylene,
and 1,1,1-trichloroethane. Environ. Health Perspect. 110:1031-1039.
Bae, D. S., Hanneman, W. H., Yang, R. S. H., and Campain, J. A. 2002.
Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in
human keratinocytes: Application of cDNA microarray technology. Environ. Health Perspect. 110 (Supplement 6):931-941.
Liao, K. H., Dobrev, I., Dennison, Jr., J. E., Andersen, M. E., Reisfeld, B., Reardon, K. F.,
Campain, J. A., Wei, W., Klein, M. T., Quann, R. J., Yang, R. S. H. 2002. Application
of biologically based computer modeling to simple or complex mixtures. Environ. Health Perspect.
110 (Supplement 6):957-963.
Klein, M. T., Hou, G., Quann, R., Wei, W., Liao, K. H., Yang, R. S. H., Campain, J. A., Mazurek, M.,
and Broadbelt, L, J. 2002. BioMOL: A computer-assisted biological modeling tool for complex chemical
mixtures and biological processes at the molecular level. Environ. Health Perspect. 110
(Supplement 6):1025-1029.
Andersen, M. E., Yang, R. S. H., French, C. T., Chubb, L. S., and Dennison, J. E. 2002. Molecular
circuits, biological switches and non-linear dose-response relationships. Environ. Health Perspect.
110 (Supplement 6):971-978.
Teuschler, L., Klaunig, J., Carney, E., Chambers, J., Connolly, R., Gennings, C., Giesy, J., Hertzberg,
R., Klaassen, C., Kodell, R., Paustenbach, D., Yang, R. 2002. Support of science-based decisions
concerning the evaluation of the toxicology of mixtures: A new beginning. Regulatory Toxicol. Pharmacol.
36:34-39.
Dennison, J. E., Andersen, M.E., and Yang, R.S.H. 2003. Characterization of the pharmacokinetics
of gasoline using PBPK modeling with a complex mixture chemical lumping approach. Inhalation Toxicol.
15:961-968.
Ou, Y.C., Connolly, R.B., Lapidot, S. A., Thomas, R.S., Gustafson, D. L., Long, M. E., Dobrev, I.,
Chubb, L., Xu, Y., Andersen, M.E., Pitot, H.C., and Yang, R.S.H. 2003. Stochastic
simulations of liver foci development in a medium-term bioassay for four chlorobenzene congeners.
Toxicol. Sci. 73:301-314.
Bae, D., Handa, R. J., Yang, R. S. H., and Campain, J. A. 2003. Gene expression
patterns as potential molecular biomarkers for malignant cellular transformation in human keratinocytes
treated with MNNG, arsenic, or metal mixture. Toxicol. Sci. 74:32-42.
Perez, D. S., Fox, M., Yang, R. S. H., and Campain, J. A. 2003. Arsenic and
benzo[a]pyrene differentially alter the capacity for differentiation and growth properties of primary
human epidermal keratinocytes. Toxicol. Sci. 76: 280-90.
Yang, R. S. H., Andersen, M. E., Dennison, J. E., Ou, Y.C., Liao, K. H.,
and Reisfeld, B. 2004. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling, in
"Mouse Models of Cancer," Ed. E. C. Holland, Wiley Inc., New York, NY, pp. 391-405.
Dennison, J. E., Andersen, M.E., Dobrev, I. D., Mumtaz, M. M., and Yang, R.S.H. 2004.
PBPK modeling of complex hydrocarbon mixtures: Gasoline. Environ. Toxicol. Pharmacol. 16:107-119.
Yang, R. S. H., El-Masri, H. A., Thomas, R. S., Dobrev, I., Dennison, Jr., J. E.,
Bae, D. S., Campain, J. A., Liao, K. H., Reisfeld, B., Andersen, M. E., Mumtaz, M. M. 2004. Chemical
mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology.
Environ. Toxicol. Pharmacol. 18:65-81.
Reisfeld, B., and Yang, R. S. H. 2004. A reaction network model for
CYP2E1-mediated metabolism of toxicant mixtures. Environ. Toxicol. Pharmacol. 18:173-179.
Dennison, J. E., Andersen, M. E., Clewell, H. J., and Yang, R. S. H. 2004.
Development of a PBPK model for volatile fractions of gasoline using chemical lumping analyses.
Environ. Sci. Tech. 38:5674-5681.
Dennison, J. E., Bigelow, P. L., Mumtaz, M. M., Andersen, M. E., Dobrev, I. D., and
Yang, R. S. H. 2005. Evaluation of potential toxicity from co-exposure to
three CNS depressants (toluene, ethylbenzene, and xylenes) under resting and working conditions
using PBPK modeling. J. Occup. Environ. Health 2:127-135.
Reddy, M., Yang, R. S. H., Clewell III, H. J., and Andersen, M. E. 2005.
Physiologically Based
Pharmacokinetics: Science and Applications, John Wiley & Sons, 420 pp.
Mayeno, A. N., Yang, R. S. H., and Reisfeld, B. 2005. Biochemical Reaction
Network Modeling: A New Tool for Predicting Metabolism of Chemical Mixtures.
Environ. Sci. Tech. 39:5363-5371.
Lu, Y., Lohitnavy, M., Reddy, M. B., Lohitnavy, O., and Yang, R. S. H. 2006.
An updated physiologically based pharmacokinetic modeling of hexachlorobenzene: Incorporation of
pathophysiological states following partial hepatectomy and hexachlorobenzene treatment.
Toxicol. Sci. 91:29-41.
Lee, S. K., Ou, Y. C., Andersen, M. E., and Yang, R. S. H. 2006. A
physiologically-based pharmacokinetic model for lactational transfer of PCB153 with or without
co-exposure of PCB 126 in mice. Arch. Toxicol. 2007.
Yang, R. S. H., and Lu, Y. 2007. The Application of Physiologically Based Pharmacokinetic
(PBPK) Modeling to Risk Assessment, in "Risk Assessment for Environmental Health," Eds. M. G.
Robson and W. A. Toscano, John Wiley & Sons, Hoboken, NJ., pp. 85-120.
Reisfeld, B., Mayeno, A. N., Lyons, M. A., and Yang, R. S. H. 2007. Physiologically-Based
Pharmacokinetic and Pharmacodynamic Modeling, in Computational Toxicology. Risk Assessment For
Pharmaceutical and Environmental Chemicals, Ed. S. Ekins, John Wiley & Sons, Hoboken, NJ.,
pp. 33-69.
Yang, R. S. H., Chang, L. W., Wu, J. P., Tsai, M. H., Wang, H. J., Kuo, Y. C., Yeh, T. K., Yang,
C. S., and Lin, P. P. 2007. Persistent tissue kinetics and redistribution of a nanoparticle,
Quantum Dot 705, in mice: ICP-MS quantitative assessment. Environ. Health Perspect.
[Online publication, 14 June 2007]
http://ehp.niehs.nih.gov/docs/2007/10290/abstract.html.
Belfiore, C. J., Yang, R. S. H., Chubb, L. S., Lohitnavy, M., Lohitnavy, O. S., and Andersen, M. E.
2007. Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic
modeling. Toxicology 234:59-72.
Yang, R. S. H., and Dennison, J. E., Jr. 2007. Initial analyses of the relationship between
"thresholds" of toxicity for individual chemicals and "interaction thresholds" for chemical
mixtures. Toxicol. Appl. Pharmacol. In press.
Lu, Y., Lohitnavy, M., Reddy, M., Lohitnavy, O., Eickman, E., Ashley, A., Gerjevic, L., Xu, Y.,
Conolly, R. B., and Yang, R. S. H. 2007. Quantitative analysis of liver GST-P foci promoted by a
chemical mixture of hexachlorobenzene and PCB 126: Implication of size-dependent cellular growth
kinetics. Arch. Toxicol. In press.
Mailing Address
Environmental & Radiological Health Sciences
1681Campus Delivery
Colorado State University
Fort Collins, CO 80523
Phone: (970) 491-7038
Fax: (970) 491-2940
Email:
ERHSDepartment
