Colorado State University link College of Veterinary Medicine and Biomedical Sciences link College of Veterinary Medicine and Biomedical Sciences logo
Department of Environmental and Radiological Health Sciences link
   CSU Home     Search CSU     CVMBS Home     Site Index     Students     RamCT  
Environmental Health Undergraduate | Graduate
Faculty | Staff | Graduate Assistants
Health & Safety Consultation | HICAHS |
University | Department |

 

Robert L. Ullrich

Robert L. Ullrich, Ph.D.
Professor and Director, Research in Oncology, Animal Cancer Center

Phone: (970) 491-6674
Fax: (970) 491-0623
Email: Robert.Ullrich@colostate.edu
Office: 433 Molecular and Radiological Biosciences Building

 

Degrees

Research Interests

Dr. Ullrich's research is focused on delineating mechanisms involved in mammary tumor development after radiation exposure, the genetic control of susceptibility, and mapping the loci involved. Studies using this approach have suggested a mechanistic link between radiation-induced genomic instability and early events in radiation-induced mammary cancer. Because of this potential link, research has also begun aimed at exploring mechanisms of radiation-induced genomic instability. The underlying hypothesis of these studies is that tumor-associated genomic instability is preferentially expressed in certain recombinogenic genomic domains and that these may be cell lineage-specific.

Dr. Ullrich is also responsible for oversight and coordination of activities for the 12 research laboratories within the Animal Cancer Center. Research within these laboratories encompasses basic cancer biology as well as the development of new approaches for cancer diagnosis and treatment.

Selected Publications

  • Siddiqui F, Li CY, LaRue S, Dewhirst MW, Ullrich R. Characterization of a recombinant adenovirus vector encoding heat inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy. Int J. of Hyperthermia, 22(2): 117-134, 2006.
  • Darakhshan F, Badie C, Moody J, Coster M, Finnon R, Finnon P, Edwards AA, M. Szluinska M, C. J. Skidmore CJ, Yoshida K, Ullrich R, Cox R and Bouffler SD. Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Carcinogenesis, 27:311-318, 2006
  • Pati D, Haddad B, Thompson H, Kittrell FS, Shepard A, Montagna C, McCarthy M, Ullrich RL, Medina D. Hormone-induced chromosomal instability in p53 null mammary epithelium. Cancer Res. 64: 5608-5616, 2004.
  • Ullrich RL. Etiology of Cancer: Physical Factors. In: Principals and Practice of Oncology. 7th edition. DeVita, Hellman, and Rosenberg (eds.), pp 195-207, 2004.
  • Bailey SM, Cornforth MN, Ullrich RL, Goodwin EH. Dysfunctional Mammalian Telomeres Join with DNA Double-Strand Breaks. DNA Repair 3: 349-357, 2004.
  • Bailey SM, Brenneman MA, Halbrook J, Nickoloff JA, Ullrich RL, Goodwin EH. The Kinase Activity of DNA-PK is Required to Protect Mammalian Telomeres. DNA Repair 3: 225-231, 2004.
  • D. Medina, F.S. Kittrel, A. Shepard, L.C. Stephens, C. Jiang, J. Lu, D.C. Allred, M. McCarthy, and R.L. Ullrich. Biological and genetic properties of the preneoplastic mammary epithelium of the p53 null mouse. The FASEB Journal, 16:881-883, 2002.
  • Daniel Medina, Robert Ullrich, Ray Meyn, Roger Wiseman, and Larry Donehower. Environmental carcinogens and p53 tumor suppressor gene interactions for mammary carcinogenesis in a transgenic mouse model. Environmental Mutagenesis 39, 178-183, 2002.
  • Michael M. Weil, Frances S. Kittrel, Yongjia Yu, Maureen McCarthy, Ryan C. Zabrisky, and R.L. Ullrich. Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice. Oncogene 20:4409-4411,2001.
  • Y. Yu, R. Okayasu, M. Weil, A. Silver, M. McCarthy, R. Zabriskie, R. Cox, and R.L. Ullrich. Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA PKcs) gene. Cancer Research 61: 1820-1824, 2001
  • R.L. Ullrich. Etiology of Cancer: Physical Factors. In: Principals and Practice of Oncology. 6th edition. DeVita, Hellman, and Rosenberg (eds.), pp 195-207, 2001.
  • R. Okayasu, K. Suetomi, Y. Yu, A. Silver, J.S. Bedford, R. Cox and R.L. Ullrich. A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive Balb/c mouse. Ca. Res. 60: 4342-4345, 2000.
  • T.M. Goepfert, M, McCarthy, F.S. Kittrell, C. Stephens, R.L. Ullrich, B.R. Brinkley, and D. Medina. Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells. The FASEB Journal 14:2221-2229, 2000.
  • Mailing Address

    Environmental & Radiological Health Sciences
    1681Campus Delivery
    Colorado State University
    Fort Collins, CO 80523
    Phone: (970) 491-7038
    Fax: (970) 491-2940
    Email: ERHSDepartment