Robert L. Ullrich, Ph.D.
Professor and Director, Research in Oncology, Animal Cancer Center
Phone: (970) 491-6674
Fax: (970) 491-0623
Email:
Robert.Ullrich@colostate.edu
Office: 433 Molecular and Radiological Biosciences Building
Degrees
- Ph.D., Radiation Biology, University of Rochester, New York
- M.S., Physiology, Creighton University
- B.S., Biology/Chemistry, Creighton University
Research Interests
Dr. Ullrich's research is focused on delineating mechanisms involved in mammary tumor development
after radiation exposure, the genetic control of susceptibility, and mapping the loci involved.
Studies using this approach have suggested a mechanistic link between radiation-induced genomic instability
and early events in radiation-induced mammary cancer. Because of this potential link, research has also
begun aimed at exploring mechanisms of radiation-induced genomic instability. The underlying hypothesis
of these studies is that tumor-associated genomic instability is preferentially expressed
in certain recombinogenic genomic domains and that these may be cell lineage-specific.
Dr. Ullrich is also responsible for oversight and coordination of activities for the 12 research
laboratories within the Animal Cancer Center. Research within these laboratories encompasses basic
cancer biology as well as the development of new approaches for cancer diagnosis and treatment.
Selected Publications
Siddiqui F, Li CY, LaRue S, Dewhirst MW, Ullrich R. Characterization of a recombinant adenovirus
vector encoding heat inducible feline interleukin-12 for use in hyperthermia-induced gene-therapy.
Int J. of Hyperthermia, 22(2): 117-134, 2006.
Darakhshan F, Badie C, Moody J, Coster M, Finnon R, Finnon P, Edwards AA, M. Szluinska M, C. J.
Skidmore CJ, Yoshida K, Ullrich R, Cox R and Bouffler SD. Evidence for complex multigenic inheritance of
radiation AML susceptibility in mice revealed using a surrogate phenotypic assay. Carcinogenesis,
27:311-318, 2006
Pati D, Haddad B, Thompson H, Kittrell FS, Shepard A, Montagna C, McCarthy M, Ullrich RL, Medina D.
Hormone-induced chromosomal instability in p53 null mammary epithelium. Cancer Res. 64: 5608-5616, 2004.
Ullrich RL. Etiology of Cancer: Physical Factors. In: Principals and Practice of Oncology.
7th edition. DeVita, Hellman, and Rosenberg (eds.), pp 195-207, 2004.
Bailey SM, Cornforth MN, Ullrich RL, Goodwin EH. Dysfunctional Mammalian Telomeres Join with DNA
Double-Strand Breaks. DNA Repair 3: 349-357, 2004.
Bailey SM, Brenneman MA, Halbrook J, Nickoloff JA, Ullrich RL, Goodwin EH. The Kinase Activity of
DNA-PK is Required to Protect Mammalian Telomeres. DNA Repair 3: 225-231, 2004.
D. Medina, F.S. Kittrel, A. Shepard, L.C. Stephens, C. Jiang, J. Lu, D.C. Allred,
M. McCarthy, and R.L. Ullrich. Biological and genetic properties of the preneoplastic
mammary epithelium of the p53 null mouse. The FASEB Journal, 16:881-883, 2002.
Daniel Medina, Robert Ullrich, Ray Meyn, Roger Wiseman, and Larry Donehower.
Environmental carcinogens and p53 tumor suppressor gene interactions for
mammary carcinogenesis in a transgenic mouse model. Environmental Mutagenesis
39, 178-183, 2002.
Michael M. Weil, Frances S. Kittrel, Yongjia Yu, Maureen McCarthy, Ryan
C. Zabrisky, and R.L. Ullrich. Radiation induces genomic instability
and mammary ductal dysplasia in Atm heterozygous mice. Oncogene 20:4409-4411,2001.
Y. Yu, R. Okayasu, M. Weil, A. Silver, M. McCarthy, R. Zabriskie, R. Cox, and
R.L. Ullrich. Elevated breast cancer risk in irradiated
BALB/c mice associates with unique functional polymorphism
of the Prkdc (DNA PKcs) gene. Cancer Research 61: 1820-1824, 2001
R.L. Ullrich. Etiology of Cancer: Physical Factors. In: Principals
and Practice of Oncology. 6th edition. DeVita, Hellman, and Rosenberg (eds.),
pp 195-207, 2001.
R. Okayasu, K. Suetomi, Y. Yu, A. Silver, J.S. Bedford, R. Cox and
R.L. Ullrich. A deficiency in DNA repair and DNA-PKcs expression in
the radiosensitive Balb/c mouse. Ca. Res. 60: 4342-4345, 2000.
T.M. Goepfert, M, McCarthy, F.S. Kittrell, C. Stephens, R.L. Ullrich, B.R.
Brinkley, and D. Medina. Progesterone facilitates chromosome instability
(aneuploidy) in p53 null normal mammary epithelial cells. The FASEB
Journal 14:2221-2229, 2000.
Mailing Address
Environmental & Radiological Health Sciences
1681Campus Delivery
Colorado State University
Fort Collins, CO 80523
Phone: (970) 491-7038
Fax: (970) 491-2940
Email:
ERHSDepartment