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Jennifer Peel

Yuanlin Peng, Ph.D.
Assistant Professor

Phone: (970) 491-0572
Fax: (970) 491-0623
Office: 439 A Molecular and Radiological Biosciences Building



Research Interests

Genetic Factors Affecting Susceptibility to Low Dose and Dose Rate Irradiation
This project addresses the identification of new (previously unknown) genes or polymorphic alleles of known genes affecting chromosomal radiosensitivity following low-dose and low dose-rate irradiation of human cells with gamma-rays. The emphasis is on genes and polymorphisms that can be directly demonstrated to affect ionizing radiation sensitivity in a way that is relevant for radiation carcinogenesis and risk assessment.

Selected Publications

•  Li, F., Huang, Q., Chen, J., Peng, Y., Roop, D., Bedford, JS., and Li, C-Y. Apoptotic Cells Activate the "Phoenix Rising" Pathway to Promote Tissue Regeneration. Science Signaling (in press).

•  Joel S. Bedford, Hatsumi Nagasawa, Takamitsu A Kato, Paul F. Wilson, Yuanlin Peng. Variations among Individuals in Cellular Radiasensitivity. Radiation Research (in press).

• Takamitsu A Kato, Paul F. Wilson, Hatsumi Nagasawa, Yuanlin Peng, and Joel S. Bedford. Variations in Radiosensitivity among Individuals: A Potential Impact on Risk Assessment? Health Physics 97(5):470-480, 2009.

• Bin Yan, Yuanlin Peng, and Chuan-Yuan Li. Molecular Analysis of Genetic Instability Caused by Chronic Inflammation. Methods in Molecular Biology 512: 484-493, 2009.

• Yu-Fen Lin, Hatsumi Nagasawa, Yuanlin Peng, Eric Y. Chuang, and Joel. S. Bedford. Comparison of Cellular Radiation Effects in Human MCF-10A Mammary Epithelial Cells Cultured as 2D Monolayers or 3D Acinar Structures in Matrigel: Cell killing, Chromosomal Aberration Production, and γ-H2AX Foci after Acute or Chronic Exposure to γ-Rays. Radiation Research 171 (6): 708-715, 2009.

• Yuanlin Peng, Thomas B. Borak, Simon D. Bouffler, Robert L. Ullrich, Michael M. Weil, and Joel S. Bedford. Radiation Leukemogenesis in Mice: Loss of PU.1 on Chromosome 2 in CBA/Ca and C57BL/6 Mice after Irradiation with 1 GeV/n 56Fe Ions or γ-Rays. Part II. Theoretical Considerations Based on Microdosimetry and the Initial Induction of Chromosome Aberrations. Radiation Research 171(4): 184-193, 2009.

• Yuanlin Peng, Natalie Brown, Rosemary Finnon, Christy L. Warner, Xianan Liu, Paula C. Genik, Matthew A. Callan, F. Andrew Ray, Thomas B. Borak, Christophe Badie, Simon D. Bouffler, Robert L. Ullrich, Joel S. Bedford, and Michael M. Weil. Radiation Leukemogenesis in Mice: Loss of PU.1 on Chromosome 2 in CBA/Ca and C57BL/6 Mice after Irradiation with 1 GeV/n 56Fe Ions, X- or γ-rays. Part I. Experimental Observations. Radiation Research 171(4): 174-183, 2009.

• Eric Y. Chuang, Xi Chen, Mong-Hsun Tsai, Hailing Yan, Chuan-Yuan Li, James B. Mitchell, Hatsumi Nagasawa, Paul F. Wilson, Yuanlin Peng, Markus M. Fitzek, Joel S. Bedford, John B. Little. Abnormal gene expression profiles in unaffected parents of patients with hereditary-type retinoblastoma. Cancer Research 66(7): 3428-3433, 2006.

• Bin Yan , Huili Wang , Yuanlin Peng, Ye Hu, He Wang, Xiuwu Zhang, Qi Chen, Joel S. Bedford, Mark W. Dewhirst, Chuan-Yuan Li. A unique role of the DNA fragmentation factor in maintaining genomic stability. Proceedings of National Academy of Sciences USA 103(5): 1504-1509, 2006.

• Qinming Zhang, Eli S. Williams, Kristin F. Askin, Yuanlin Peng, Joel S. Bedford, Howard L. Liber, Susan M. Bailey. Suppression of DNA-PK by RNAi Has Different Quantitative Effects on Telomere Dysfunction and Mutagenesis in Human Lymphoblasts Treated with γ–rays or HZE particles. Radiation Research 164: 497-504, 2005.

• Hatsumi Nagasawa, Yuanlin Peng, Paul F. Wilson, Yi-ching Lio, David J. Chen, Joel S. Bedford, John B. Little. Role of Homologous Recombination in the Alpha Particle Bystander Effect for Sister Chromatid Exchanges and Chromosomal Aberrations. Radiation Research 163, 164(2):141-147, 2005.

• Yuanlin Peng, Rick G. Woods, Heather Beamish, Ruiqiong Ye, Susan P. Lees-Miller, Martin F. Lavin, Joel S. Bedford. Deficiency in the Catalytic Subunit of DNA-Dependent Protein Kinase Causes Down-regulation of ATM. Cancer Research 65(5): 1670-1677, 2005.

• Yuanlin Peng, Qinming Zhang, Hatsumi Nagasawa, Ryuichi Okayasu, Howard L. Liber, Joel S. Bedford. DNA-PKcs Silencing by siRNA Sensitizes Human Cells for Radiation-Induced Chromosome Damage, Cell Killing and Mutation. Cancer Research 62(22): 6400-6404, 2002.

Mailing Address
Environmental & Radiological Health Sciences
1618 Campus Delivery
Colorado State University
Fort Collins, CO 80523
Phone: (970) 491-5222
Fax: (970) 491-0623
Email: ERHSDepartment