Marie Legare, DVM, Ph.D.
Associate Professor

Phone: (970) 491-7043
Fax: (970) 491-7569
Email: Marie.Legare@colostate.edu
Office: 133 Physiology

 

Degrees

• Ph.D., Veterinary Anatomy, Texas A & M University
• DVM, Texas A & M University
• M.S., Biomedical Science, Montana State University
• B.S., Zoology, Montana State University
  

Research Interests

Analysis of genes and gene expression.

Selected Publications

 • VonMaier MS, Hanneman WH, Thomas R, Liu W, Legare ME. Gene expression profiles foretell divergent effects on 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in liver and brain tissues. Neurotoxicol (Accepted 2006).
 • Weber NM, Sawyer HR, Legare ME, Veeramachaneni DNR. Sub-chronic exposure to dibromoacetic acid, a water disinfection by-product, does not affect gametogenic potential in mice. Toxicol Sci 89(1):325-330 2006
 • Flint AF, U'Ren L, Legare ME, Withrow SJ, Dernell W, Hanneman WH. Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. Vet Pathol 41(3): 291-296, 2004
 • Mazaferro EM, Eubig PA, Hackett TB, Legare ME, Miller C, Wingfield WE, Wise L. Acute renal failure associated with raisin or grape ingestion in 4 dogs. J Vet Emerg Crit Care 14(3):203-212, 2004
 • Chubb LS, Andersen ME, Broccardo CJ, Legare ME, Billings RE, Dean CE, Hanneman WH. Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. Toxicol Pathol 32:(4)467-473, 2004.
 • Legare ME, Hanneman WH. Genetic, biochemical and anatomic characterization of neurological mutant 3, a new mouse model for Parkinson's disease. Genetic Molecular Res 2(3):288-294, 2003
 • VonMaier MS, Legare ME, Hanneman WH. How does dioxin affect gene expression in nerve cells: identifying novel dioxin-inducible gene targets in neuronal cells. Proc Soc Tox, 2003
 • Hanneman WH, Andersen M, Legare ME, French T, McMUllin T, Broccardo C, Billings R. The exposure dose-response paradigm as it relates to toxicogenomics. In: In Vitro Neurotoxicology: Principles and Challenges. Mannfred Hollinger, (ed). Human Press Inc, 2003
 • Legare ME, Mason GL. Microcystin and hepatotoxicity. AFIP Conference 2003.
 • Nystuen A, Legare ME, Shultz LD, Frankel WN. A null mutation in inositol polyphosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron 32(2):203-12, 2001
 • Bryda E, Hung JK, Legare ME, Frankel W, Noben-Trauth K. High resolution genetic and physical mapping of Modifier-of-deafwaddler (mdfw) and waltzer (Cdh23v). Genomics 73:338-342, 2001
 • Legare ME, Hanneman WH, Barhoumi R, Burghardt RC, and Tiffany Castiglioni E. 2,3,7,8 tetrachlorodibenzo p dioxin alters hippocampal astroglia-neuronal gap junctional communication. Neurotoxicol 21(6):1109-16, 2000
 • Legare ME, Bartlett FS, Frankel WN. A major effect QTL determined by multiple genes in epileptic EL mice. Genome Res 10(1):42-8, 2000
 • Legare ME, Frankel WNF. Multiple seizure susceptibility genes on Chromosome 7 in SWXL-4 congenic mouse strains. Genomics 70(1):62-5, 2000
 • Lindahl, LS, Bird L, Legare ME, Mikeska G, Bratton GR, Tiffany-Castiglioni E. Differential ability of astroglia and neuronal cells to accumulate lead: dependence on cell type and degree of differentiation. Toxicol Sci 50(2):236-243, 1999
 • Tiffany-Castiglioni, E., Legare, M.E., Barhoumi, R., Burghardt, R.C., and Schneider, L. 1998. Comparison of Low-level Lead Effects on Astroglia Exposed in vivo or in vitro.  The Toxicologist.
 • Legare, M.E., Barhoumi, R., Hebert, E., Bratton, G.R.., Burghardt, R.C., and Tiffany-Castiglioni, E. 1998. Analyis of Pb²⁺ Entry into Cultured Astroglia. Toxicological Sciences 46(1):90-100.
 • Legare, M.E., Hanneman, W.H., Barhoumi, R., and Tiffany-Castiglioni, E.  1997.  The Effects of 2,3,7,8-tetrachlorodibenzo -p-dioxin Exposure in Primary Rat Astroglia: Identification of Biochemical and Cellular Targets.  Neurotoxicology 18(2):515-524.
 • Hanneman, W.H., Legare, M.E., Sweeney, S., and Schimenti, J.C.  1997.  Cisplatin Increases Meiotic Crossing-over in Mice.  Proceedings of the National Academy of Sciences 94:8681-8685.
 • Hanneman, W.H., Legare, M.E., Tiffany-Castiglioni, E., and Safe, S.H.  1996.  The Need for Cellular, Biochemical and Mechanistic Studies in PCB Neurotoxicity.  Neurotoxiology and Teratrology 18(3):247-250.
 • Hanneman, W.H., Legare, M.E., Barhoumi, R., Burghardt, R.C., Safe, S.H., and Tiffany-Castiglioni, E.  1996.  Stimulation of Calcium Uptake in Cultured Rat Hippocampal Neurons by 2,3,7,8-tetrachlorodibenzo-p-dioxin.  Toxicology 112:19-28.