Lesley M. Butler, Ph.D.
Assistant Professor

Phone: (970) 492-4055
Fax: (970) 491-2940
Email: Lesley.Butler@colostate.edu
Office: 141 A Environmental Health Building

Degrees

• Ph.D., Epidemiology, University of North Carolina, Chapel Hill
• M.S., Epidemiology, University of North Carolina, Chapel Hill
• B.S., Biological Sciences, University of California, Davis

Research Interests

The underlying goal of my research is to define relationships between dietary factors and cancer by using epidemiology methods in combination with tools from chemistry and genetics, such as dietary biomarkers and genetic polymorphisms that relate to the detoxification and activation of dietary compounds. My projects address research hypotheses that are informed by experimental evidence, and therefore produce results with the greatest potential for elucidating underlying diet-cancer mechanisms and impacting public health. Past projects include evaluating heterocyclic amine exposure from cooked meat and risk of colon cancer, and genetic susceptibility to these dietary compounds. My current projects include evaluating various diet and cancer hypotheses, specific to colorectal, breast and prostate cancer risk in a large prospective cohort of Singapore Chinese.

Selected Publications

Refereed Publications

Butler LM, Wang R, Wong AS, Koh WP, Yu MC. Cigarette smoking and risk of prostate cancer among Singapore Chinese. Cancer Causes Control 2009 (in press).

Butler LM, Wang R, Koh WP, Stern M, Yuan JM, Yu MC. Marine n-3 fatty acids in relation to risk of colorectal cancer in Singapore Chinese: a prospective study. Int J Cancer 2009;124:678-86.

Butler LM, Wang R, Koh WP, Yu MC. Prospective study of dietary patterns and colorectal cancer among Singapore Chinese. Br J Cancer 2008;99:1511-6.

Butler LM, Millikan RC, Sinha R, Keku TO, Winkel S, Harlan B, Eaton A, Gammon MD, Sandler RS. Modification by N-Acetyltransferase 1 genotype on the association between heterocyclic amines and colon cancer in a multiethnic study. Mutat Res 2008;638:162-174.

Girard H, Butler LM, Villeneuve L, Millikan RC, Sinha R, Sandler RS, Guillemette C. UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African Americans. Mutat Res 2008;644:56-63.

Butler LM, Sinha R, Millikan RC, Martin CF, Newman B, Gammon MD, Ammerman AS, Sandler RS. Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study. Am J Epidemiol. 2003;157(5):434-45.

Butler LM, Gold EB, Greendale GA, Crandall CJ, Modugno F, Oestreicher N, Quesenberry CP, Habel LA. Menstrual and reproductive factors in relation to mammographic density: the Study of Women’s Health Across the Nation (SWAN). Breast Cancer Res Treat 2008;112:165-174.

Oestreicher N, Habel LA, Bromberger J, Butler L, Capra A, Crandall CJ, Gold EB, Greendale GA, Modugno F, Sternfeld B. Physical activity and mammographic density in a cohort of midlife women. Med Sci Sports Exerc 2008;40:451-456.

Abstracts

Butler LM, Wang R, Koh WP, Wong A, Yuan JM, Yu MC. Calcium intake increases risk of prostate cancer among Singapore Chinese. American Association for Cancer Research, April 2009.

Conroy SM, Butler LM, Gold EB, Crandall CJ, Greendale GA, Oestreicher N, Quesenberry CP, Habel LA. Cigarette smoking and mammographic density: The Study of Women’s Health Across the Nation (SWAN). American Association for Cancer Research, April 2009.

Hugo Girard H, Butler LM, Villeneuve L, Millikan RC, Sinha R, Sandler RS, Guillemette C. UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African Americans. 12th International Glucuronidation Workshop, July 2008.

Conroy SM, Butler LM, Harvey D, Gold EB, Sternfeld B, Bromberger J, Oestreicher N, Habel LA. Physical activity and changes in mammographic density during menopause. Society of Epidemiology Research, June 2008.

Butler LM, Wang R, Koh WP, Yu MC. Dietary patterns and colorectal cancer risk: The Singapore Chinese Health Study. American Association for Cancer Research, April 2008.