Joel S. Bedford
Phone: (970) 491-7492
Fax: (970) 491-0623
Office: 441 Molecular and Radiological Biosciences Building
- Ph.D., Radiobiology, Oxford University, Oxford, England
- M.S., Radiology, University of Colorado Medical School, Denver, CO
- B.S., Chemistry, University of Colorado, Boulder, CO
Dr. Bedford's interests: Chromosomal aberrations are principally involved in all of the important
biological effects of exposure to ionizing radiations. These include cell killing which underlies effects
in normal tissues and tumors after high level exposures administered for cancer treatment, as well as
heritable changes in cells which are not killed. Such mutational events can affect the offspring of
irradiated parents when they occur in germ cells, or in some cases, cancer if the wrong kind are produced
in somatic cells.
Research projects in Dr. Bedford's laboratory involve studies in radiation genetics
and cytogenetics, including mechanisms involved in the production of chromosomal
aberrations by ionizing radiations and other agents, factors influencing
this production, the development of new methodologies for measuring aberrations,
the genetic control of radiosensitivity, and radiation induced genomic
instability. Additional studies deal with cell cycle perturbations resulting
from radiation exposure.
- Dugan, L.C., Bedford J.S.. Are chromosomal instabilities induced by exposure
of cultured normal human cells to low- or high LET radiation? Radiat. Res. 159:000-000. (In press, 2003).
- Ulsh, B.A., L.C. Dugan, T.G. Hinton, F.W. Whicker, and Bedford J.S..
Environmental Biodosimetry: A genetically relevant tool for biomonitoring
and ecological risk assessment. J. Environ. Radioact. 47:57-70, 2003
- Peng, Y., Q. Zhang, H. Nagasawa, R. Okayasu, H.L. Liber, and Bedford J.S..
DNA-PKcs silencing by siRNA sensitizes human cells for radiation-induced chromosome damage, cell killing
and mutation. Cancer Research 62:6400-6404, 2002.
- Bedford J.S. and W.C. Dewey. Historical and current highlights in radiation
biology: Has anything important been learned by irradiating cells? Radiation Research 158:251-291, 2002.
- Jha, M.N., J.R. Bamburg, B. Bernstein and Bedford J.S.. Caffeine eliminates gamma-ray
induced G2 delay in human tumor but not in normal cell lines. Radiation Research 157:26-31, 2002.
- Ulsh, B.A., J.D. Congdon, , T.G. Hinton, F.W. Whicker, and J.S. Bedford.
Culture methods for turtle lymphocytes. Methods in Cell Science 22:285-295, 2001.
- Bedford J.S. The radiobiology of low dose-rate and fractionated irradiation.
In: Principles and Practice of Brachytherapy, (Joslin, Flynn, and Hall, eds) Edward Arnold (Publishers) Ltd., 2001, pp.161-179
- Muhlmann-Diaz, M.C., B.A. Ulsh, F.W. Whicker, T.G. Hinton, J.D. Congdon and Bedford J.S. Conservation of chromosome 1 in turtles over 66
million years. Cytogenet. Cell Genet. 92:139-143, 2001
- Ulsh, B.A., F.W. Whicker, T.G. Hinton, J.D. Congdon and Bedford J.S..
Chromosome Translocations in T. scripta : The dose-rate effect and in vivo lymphocyte
radiation response. Radiat. Res. 155: 63-73 (2001)
- Okayasu, R., K. Suetomi, Y. Yu, Bedford J.S., R. Cox and R.L. Ullrich.
A deficiency in DNA repair and DNA-Pkcs expression associates with susceptibility
to solid tumor development in BALB/c mice. Cancer Res. 60:4342-4345, 2000.
- Ulsh, B.A., M.C. Mühlmann-Diaz, F.W. Whicker, T.G. Hinton, J.D. Congdon, and
Bedford J.S.. Chromosome translocations in turtles: A biomarker in a sentinel
animal for ecological dosimetry. Radiat. Res. 153:752-759, 2000.
Environmental & Radiological Health Sciences
1618 Campus Delivery
Colorado State University
Fort Collins, CO 80523
Phone: (970) 491-5222
Fax: (970) 491-0623