Joel S. Bedford
Professor

Phone: (970) 491-7492
Fax: (970) 491-0623
Email: Joel.Bedford@colostate.edu
Office: 441 Molecular and Radiological Biosciences Building

Degrees

• Ph.D., Radiobiology, Oxford University, Oxford, England
• M.S., Radiology, University of Colorado Medical School, Denver, CO
• B.S., Chemistry, University of Colorado, Boulder, CO

Research Interests

Dr. Bedford's interests: Chromosomal aberrations are principally involved in all of the important biological effects of exposure to ionizing radiations. These include cell killing which underlies effects in normal tissues and tumors after high level exposures administered for cancer treatment, as well as heritable changes in cells which are not killed. Such mutational events can affect the offspring of irradiated parents when they occur in germ cells, or in some cases, cancer if the wrong kind are produced in somatic cells.

Research projects in Dr. Bedford's laboratory involve studies in radiation genetics and cytogenetics, including mechanisms involved in the production of chromosomal aberrations by ionizing radiations and other agents, factors influencing this production, the development of new methodologies for measuring aberrations, the genetic control of radiosensitivity, and radiation induced genomic instability. Additional studies deal with cell cycle perturbations resulting from radiation exposure.

Selected Publications

• Dugan, L.C., Bedford J.S.. Are chromosomal instabilities induced by exposure of cultured normal human cells to low- or high LET radiation? Radiat. Res. 159:000-000. (In press, 2003).
• Ulsh, B.A., L.C. Dugan, T.G. Hinton, F.W. Whicker, and Bedford J.S.. Environmental Biodosimetry: A genetically relevant tool for biomonitoring and ecological risk assessment. J. Environ. Radioact. 47:57-70, 2003
• Peng, Y., Q. Zhang, H. Nagasawa, R. Okayasu, H.L. Liber, and Bedford J.S.. DNA-PKcs silencing by siRNA sensitizes human cells for radiation-induced chromosome damage, cell killing and mutation. Cancer Research 62:6400-6404, 2002.
• Bedford J.S. and W.C. Dewey. Historical and current highlights in radiation biology: Has anything important been learned by irradiating cells? Radiation Research 158:251-291, 2002.
• Jha, M.N., J.R. Bamburg, B. Bernstein and Bedford J.S.. Caffeine eliminates gamma-ray induced G2 delay in human tumor but not in normal cell lines. Radiation Research 157:26-31, 2002.
• Ulsh, B.A., J.D. Congdon, , T.G. Hinton, F.W. Whicker, and J.S. Bedford. Culture methods for turtle lymphocytes. Methods in Cell Science 22:285-295, 2001.
• Bedford J.S. The radiobiology of low dose-rate and fractionated irradiation. In: Principles and Practice of Brachytherapy, (Joslin, Flynn, and Hall, eds) Edward Arnold (Publishers) Ltd., 2001, pp.161-179
• Muhlmann-Diaz, M.C., B.A. Ulsh, F.W. Whicker, T.G. Hinton, J.D. Congdon and Bedford J.S. Conservation of chromosome 1 in turtles over 66 million years. Cytogenet. Cell Genet. 92:139-143, 2001
• Ulsh, B.A., F.W. Whicker, T.G. Hinton, J.D. Congdon and Bedford J.S.. Chromosome Translocations in T. scripta : The dose-rate effect and in vivo lymphocyte radiation response. Radiat. Res. 155: 63-73 (2001)
• Okayasu, R., K. Suetomi, Y. Yu, Bedford J.S., R. Cox and R.L. Ullrich. A deficiency in DNA repair and DNA-Pkcs expression associates with susceptibility to solid tumor development in BALB/c mice. Cancer Res. 60:4342-4345, 2000.
• Ulsh, B.A., M.C. Mühlmann-Diaz, F.W. Whicker, T.G. Hinton, J.D. Congdon, and Bedford J.S.. Chromosome translocations in turtles: A biomarker in a sentinel animal for ecological dosimetry. Radiat. Res. 153:752-759, 2000.