J. Lucas Argueso, Ph.D.
Assistant Professor

Phone: (970) 491-3681
Fax: (970) 491-0623
Email: lucas.argueso@colostate.edu
Office: 493 Molecular and Radiological Biosciences Building

 

Degrees

• Ph.D., Genetics and Development, Cornell University, Ithaca, NY
• M.S., Genetics and Plant Breeding, University of Sao Paulo, Brazil
• B.S., Agronomic Engineering, University of Sao Paulo, Brazil

Research Interests

• Chromosomal rearrangements and phenotypic consequences of altered genome architecture
• Effects of environmental exposure on copy number variation (CNV) and chromosome structure
• Molecular mechanisms of DNA double-strand break repair
• Structural genome variation in natural yeast populations
• Genomics of industrial yeast strains and bioethanol fermentation

Selected Publications

• Nishant, K. T., Wei, W., Mancera, E., Argueso, J. L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C., Korbel, J. O., Gu, Z., Steinmetz, L. M., Alani, E.  2010  The baker’s yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genetics, 6: e1001109.

• Argueso, J. L., Pereira, G. A. G.  2010  Perspective: Indigenous sugar cane yeast strains as ideal platforms for the delivery of next generation biorefining technologies. International Sugar Journal 112: 86-89.

• Argueso, J. L., Carazzolle, M. F., Mieczkowski, P. A., Duarte, F. M., Netto, O. V. C., Missawa, S. K., Galzerani, F., Costa, G. G. L., Vidal, R. O., Noronha, M. F., Dominska, M., Andrietta, M. G. S., Andrietta, S. R., Cunha, A. F., Gomes, L. H., Tavares, F. C. A., Alcarde, A. R., Dietrich, F. S., McCusker, J. H., Petes, T. D., Pereira, G. A. G. 2009  Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production. Genome Research, 19: 2258-2270.
  *This article was featured in Genome Research's issue cover.
  *This article was featured in the Current Topics section of Microbe Magazine (Microbe, 5:45).

• Argueso, J. L., Westmoreland, J., Mieczkowski, P. A., Gawel, M., Petes, T. D., Resnick, M. A.  2008 Double strand breaks associated with repetitive DNA can reshape the genome.  Proceedings of National Academy of Sciences of the United States of America, 105: 11845-11850.
  *This article was featured in PNAS' issue cover and Commentaries section (PNAS, 105: 11593).
  *This article was featured in Science Magazine Editors' Choice section (Science, 321: 892).

• Heck, J. A., Argueso, J. L., Gemici, Z., Reeves, R. G., Bernard, A., Aquadro, C. F., Alani, E.  2006 Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair.  Proceedings of National Academy of Sciences of the United States of America 103: 3256-3261.

• Surtees, J. A., Argueso, J. L., Alani, E.  2004  Mismatch repair proteins: Key regulators of genetic recombination.  Cytogenetic and Genome Research 107: 146-159.

• Argueso, J. L., Wanat, J., Gemici, Z., Alani, E.  2004 Competing crossover pathways act during meiosis in Saccharomyces cerevisiae. Genetics 168: 1805-1816.

• Argueso, J. L., Kijas, A. W., Sarin, S., Heck, J., Waase, M., Alani, E.  2003  Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in crossing over and vegetative and meiotic mismatch repair. Molecular and Cellular Biology 23: 873-886.

• Argueso, J. L., Smith, D., Yi, J., Waase, M., Sarin, S., Alani, E. 2002  Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over. Genetics 160: 909-921.

• Xie, Y., Liu, Y., Argueso, J. L., Henricksen, L. A., Kao, H. I., Bambara, R. A, Alani, E.  2001 Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat-tract-instability, and flap cleavage. Molecular and Cellular Biology 21: 4889-4899.

• Gomes, L.H., Duarte, K. M. R., Argueso, J. L., Echeverrigaray, S., Tavares, F. C. A.  2000  Methods for yeast characterization from industrial products. Food Microbiology 17: 217-223.

 

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Department Contact Information:

Environmental and Radiological Health Sciences
1681 Campus Delivery
Fort Collins, CO 80523

Phone: (970) 491-7038
Fax: (970) 491-2940