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William S. Dernell
Associate Professor
Oncology
Degree(s): DVM, MS
Specialty Certification(s): Diplomate, American College
of Veterinary Surgeons
Clinical Interests: Surgical Oncology, Reconstructive
Surgery, Treatment of Infection
Research Interests: Drug Delivery, Breast Cancer, Sarcomas,
Animal Modeling, Osteogenesis, Treatment of Severe Infection
Selected Publications:
Dernell WS. 2006 Initial Wound Management. Vet Clin Small Anim 36:713-738.
Lascelles BDX, Dernell WS, Correa MT, Lafferty M, Devitt CM, Kuntz
CA, Straw RC, Withrow SJ. 2005. Improved survival associated with
postoperative wound infection in dogs treated with limb-salvage surgery
for osteosarcoma. Annals Surg Oncol 12:1-4.
Mehl ML, Seguin B, Dernell WS, Lafferty M, Kass PH, Withrow SJ. 2005.
Survival analysis of one versus two treatments of local delivery cisplatin
in a biodegradable polymer for canine osteosarcoma. J Vet Comp Oncol
3:81-86.
Hillers, KR, Dernell WS, Lafferty MH, Withrow SJ, Lana SE. 2005. The
incidence and significance of lymph node metastasis in canine osteosarcoma:
A retrospective study of 228 cases (1986-2003). J Am Vet Med Assoc.
2005;226:1364-1367.
Feng L, DeLille A, Jameson VJ, Smith L, Dernell WS, Manning MC , Improved
potency of cisplatin by hydrophobic ion pairing. Cancer Chemother
Pharmacol 54:441-448.
Mullins MN, Lana SE, Dernell WS, Ogilvie GK, Withrow SJ, Ehrhart EJ.
2004. Cyclooxygenase-2 expression in canine appendicular osteosarcomas
J Vet Int Med 18:859-865. Osteosarcoma: curative-intent treatment.
Comp Cont Ed Pract Vet, 26:186-196..
Lana SE, Dernell WS, Lafferty M, Withrow SJ, LaRue SM. 2004. Use of
radiation and a slow-release cisplatin formulation for the treatment
of canine nasal tumors. Vet Radiol Ultrasound 45:577-581. of urethral
and prostatic neoplasia in 6 dogs. Vet Surg 2004;33:505-516.
Liptak JM, Dernell WS, Lascelles BDX, LaRue SM, Jameson VJ, Powers
BE, Huber DJ, Withrow SJ. Intraoperative extracorporeal irradiation
for limb sparing in 13 dogs. Vet Surg 2004; 33:446-456
.
Withrow SJ, Liptak JM, Straw RC, Dernell WS, Jameson VJ, Powers BE,
Johnson JL, Mallinckrodt CH, Brekke JH, Douple EB. 2004. Biodegradable
cisplatin polymer in limb-sparing surgery for canine osteosarcoma.
Annals Surg Oncol, 2004;11:705-713.
Burdick JA, Frankel D, Dernell WS, Anseth.KS 2003. An initial investigation
of photocurable 3-dimensional lactic acid based scaffolds in a critical-sized
cranial defect. Biomaterials 24:1613-1620.
Dernell WS, Powers BE, Taatjes DJ, Cogan P, Gaudiano G, Koch TH. 2002.
Evaluation of epidoxorubicin-formaldehyde conjugate, epidoxoform in
a mouse mammary carcinoma model. Cancer Invest, 20(5&6):713-724.
Morello E, Dernell WS, Kuntz CA, LaRue, SM, Lafferty M, Nelson A,
Brekke JH, Mallinckrodt CH, Withrow SJ, Manning MC. 2002. Evaluation
of cisplatin in combination with a biologic response modifier in a
murine mammary carcinoma model. Cancer Invest , 204(4):480-489.
Dernell WS, Gentry-Weeks C, Manning MC, Powers BE, Park RD, Lafferty
M, Kuntz CA, Shively JE, Falk RF, Meyer JD, Randolph TW, Withrow SJ.
2001. In vivo evaluation of antibiotic impregnated beads in a rat
osteomyelitis model. J Bioact Compat Polymer, 16:235-250.
Dernell WS, Withrow SJ, Kuntz CA, Dewell R, Garry FB, Powers BE, Shively
JE, Falk RF, Meyer JD, Manning MC, Randolph TW. 2001. In vivo evaluation
of gentamicin impregnated polylactic acid beads implanted in sheep.
J Bioact Compat Polymer, 16:119-135.
Bregazzi VS, Dernell WS, Huber DJ, Schochet R, Lafferty M, Powers
BE, Ogilvie GK, Withrow SJ, Manning MC. 2000. Intracavitary slow release
paclitaxel polymer in a rodent model of mammary carcinoma. J Bioact
Compat Polymer; 15:85-88.
Ehrhart, N., Dernell, W.S., Ehrhart, E.J., Hutchison, J.M., Douple,
E.B., Brekke, J.H., Straw, R.C., Withrow, S.J. 1999. The Effects of
a Controlled-Release Cisplatin Delivery System after Marginal Resection
of Breast Carcinoma. Am J Vet Res; 60(11):1347-1351.
Dernell WS. 1999. Treatment of severe orthopedic infections. Vet Clin
North Am: Small Anim Pract; 29:1261-1274.
Meyer JD, Falk RF, Kelly M, Shively JE, Withrow SJ, Dernell WS, Kroll
DJ, Randolph TW, Manning MC. 1998. Preparation and in vitro characterization
of gentamicin-impregnated biodegradable beads suitable for treatment
of osteomyelitis. J Pharm Sci; 87:1149-1154.
Dernell WS, Withrow SJ, Straw RC, Powers BE, Brekke JH, Lafferty,
M. 1998. Intracavitary treatment of soft tissue sarcomas in dogs using
cisplatin in a biodegradable polymer. Anticancer Res; 17:4499-4506.
Dernell WS, Withrow SJ, Straw RC, Powers BE, Wember EW, Jameson VJ,
Wilkins RM, Allen RE. 1998. Clinical response to antibiotic impregnated
polymethyl methacrylate bead implantation of dogs with severe infections
after limb sparing with allograft replacement; 18 cases (1994-1996).
Vet Comp Orthop Traumatol; 11:94-99.
Dunn RL, Yewey GL, Fujita SM, Josephs KR, Whitman SL, Southard GL,
Dernell WS, Straw RC, Withrow SJ, Powers BE. 1996. Sustained Release
of Cisplatin in Dogs from an Injectable Implant Delivery System. J
Bioact Comp Polym; 11:286-300.
Phone: 970-297-0336.
Graduate Students/ Residents:
1. Susan Hudacheck, PhD candidate CMB program.
Other Interests: Hiking, Camping, Fishing, Golf, Home
Improvement
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