Department of Clinical Sciences
Faculty

Doug Thamm
Assistant Professor
Oncology

Degrees:
VMD

Specialty Certification:
Diplomate, ACVIM (Oncology)

Clinical Interests:
Novel biological therapeutics for cancer

Research Interests
: Tyrosine kinase signaling in animal cancer cells, validation of biomarkers for novel therapeutics, targeted therapy to enhance chemosensitivity

Selected Publications:
Thamm DH, Dickerson EB, Akhtar N, Lewis R, Auerbach R, Helfand SC, MacEwen EG. Biological and molecular characterization of a canine hemangiosarcoma-derived cell line. Res Vet Sci 81(1): 76-86, 2006.

Thamm DH, Kurzman ID, King I, Li Z, Sznol M, Dubielzig RR, Vail DM, MacEwen EG. Systemic administration of an attenuated, tumor-targeting Salmonella typhimurium to dogs with spontaneous neoplasia: phase I evaluation. Clin Cancer Res 11(13): 4827-4834, 2005.

MacDonald VS, Thamm DH, Kurzman ID, Turek MM, Vail DM. Does L-asparaginase influence efficacy or toxicity when added to a standard CHOP protocol for dogs with lymphoma? J Vet Intern Med 19(5): 732-736, 2005.

Katayama R, Huelsmeyer MK, Kurzman ID, Thamm DH, MacEwen EG, Vail DM. Selective inhibition of platelet-derived growth factor receptor activity in feline vaccine-associated sarcoma. Cancer Chemother Pharmacol 54(1): 25-33, 2004.

MacEwen EG, Pastor J, Kutzke J, Tsan R, Kurzman ID, Thamm- DH, Wilson M, Radinsky R. IGF-1 receptor contributes to the malignant phenotype in human and canine osteosarcoma. J Cell Biochem 92(1): 77-91, 2004.

MacEwen EG, Kutzke J, Carew J, Pastor J, Schmidt JA, Tsan R, Thamm DH, Radinsky R. C-Met tyrosine kinase receptor expression and function in human and canine osteosarcoma cells. Clin Exp Metastasis 20(5): 421-430, 2003.

Poirier VJ, Huelsmeyer MK, Kurzman ID, Thamm DH, Vail DM. The bisphosphonates alendronate and zoledronate are inhibitors of canine and human osteosarcoma cell growth in vitro. Vet Compar Oncol 1(4): 207-215, 2004.

Thamm DH, Kurzman ID, MacEwen EG, Feinmehl R, Towell TL, Longhofer SL, Johnson CM, Geoly FJ, Stinchcomb DT. Lipid-complexed intralesional cytokine / superantigen immunogene therapy for spontaneous canine tumors. Cancer Immunol Immunother 52: 473-480, 2003.

Marr AK, Thamm DH, Kurzman ID, Vail DM, MacEwen EG. In vitro effects of 2-methoxyestradiol on canine tumor cells. Vet Compar Oncol 1(3): 159-167, 2003.

Thamm DH, MacEwen EG, Phillips BS, Hershey AE, Burgess KM, Pettit GR, Vail DM. Preclinical study of dolastatin-10 in dogs with spontaneously arising tumors. Cancer Chemother Pharmacol 49: 251-255, 2002.

Poirier VJ, Thamm DH, Kurzman ID, Jeglum KA, Chun R, Obradovich JE, O’Brien MG, Fred III RM, Phillips BS Vail DM. Liposome encapsulated doxorubicin (Doxil) and doxorubicin in the treatment of vaccine associated sarcoma in cats. J Vet Intern Med 16: 726-731, 2002.

Other Interests: Music, mountain biking, hiking