Department of Clinical Sciences
Faculty

Degrees:
BVSc, PhD, FRCVS, DSc, Dr. med vet (hc), Diplomate ACVS

Research Interests:
Equine orthopaedic surgery and joint disease (arthritis) research

Selected Publications:
Kawcak CE, Norrdin RW, Frisbie DD, McIlwraith CW, Trotter GW. Effects of osteochondral fragmentation and intra-articular triamcinolone acetonide treatment on subchondral bone in the equine carpus. Equine Vet J 1997; 30:66-71.

Kawcak CE, Frisbie DD, McIlwraith CW, Trotter GW, Gillette SM, Powers BE, Walton RM. Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation. Am J Vet Res 1997; 58:1132-1140.

Frisbie DD, Kawcak CE, Baxter GM, Trotter GW, Powers BE, Lassen ED, McIlwraith CW. Effects of 6a-methylprednisolone acetate on an equine osteochondral fragment exercise model. Am J Vet Res 1998; 59:1619-1628.

Norrdin RW, Kawcak CE, Capwell BA, McIlwraith CW. Calcified cartilage morphometry and its relation to subchondral bone remodeling in equine arthrosis. Bone 1999; 24:109-114.

Billinghurst RC, O'Brien K, Poole RA, McIlwraith CW. Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor. Inhibition of matrix metalloproteinases. New York Acad Sci 1999; 878:594-597.

Frisbie DD, Ray CS, Ionescu M, Poole AR, Chapman DL, McIlwraith CW. Measurement of synovial fluid and serum concentrations of the 846 epitope of chondroitin sulfate and of carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses. Am J Vet Res 1999; 60:306-309.

Frisbie DD, McIlwraith CW. Evaluation of gene therapy as a treatment for equine traumatic arthritis. A species with clinical disease. Clin Orthop Rel Res 2000; S795:5273-5287.

Kawcak CE, McIlwraith CW, Norrdin RW, Park RD, James SP. The role of subchondral bone in joint disease: A review. Equine Vet J; 33:120-126.

Billinghurst RC, Buxton EM, Edwards MG, McGraw BS, McIlwraith CW. Use of an antineoepitope antibody for identification of type II collagen degradation in articular cartilage. Am J Vet Res 2000; 62:1031-1039.

Trumble TN, Trotter GW, Oxford JRT, McIlwraith CW, Cammarata S, Goodnight JL, Billinghurst RC, Frisbie DD. Matrix metalloproteinase and cytokine expression in synovial fluid gelatinase levels in naturally occurring joint disease in horses. Am J Vet Res 2001; 62:1467-1477.

Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, McIlwraith CW. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Therapy 2002; 9:12-20