Dr. Marie Legare

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Center for Environmental Medicine
1681 Campus Delivery
Colorado State University
Fort Collins, CO 80523
Phone: (970) 491-8635
Email: CEM@colostate.edu

Degrees

PhD, Veterinary Anatomy, Texas A&M
DVM, Texas A&M
M.S., Biomedical Science, Montana State Universiy
B.S., Zoology, Montana State University

Dr. Legare is a Faculty Affiliate with the Center for Environmental Medicine and an Assistant Professor in the Department of Environmental and Radiological Health Sciences.

Research Interests

Dr. Legare is interested in how lead, mercury, pesticide residues and other agents influence health and risk of disease. Her laboratory has several different projects on-going, including a March of Dimes grant to identify genes that are disregulated after exposure to alcohol. Another study is examining the exposure of embryonic stem cells to environmental chemicals and how genes are impacted.

Recent Publications

  • VonMaier MS, Hanneman WH, Thomas R, Liu W, Legare ME. Gene expression profiles foretell divergent effects on 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in liver and brain tissues. Neurotoxicol (Accepted 2006).
  • Weber NM, Sawyer HR, Legare ME, Veeramachaneni DNR. Sub-chronic exposure to dibromoacetic acid, a water disinfection by-product, does not affect gametogenic potential in mice. Toxicol Sci 89(1):325-330 2006
  • Flint AF, U'Ren L, Legare ME, Withrow SJ, Dernell W, Hanneman WH. Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors. Vet Pathol 41(3): 291-296, 2004
  • Mazaferro EM, Eubig PA, Hackett TB, Legare ME, Miller C, Wingfield WE, Wise L. Acute renal failure associated with raisin or grape ingestion in 4 dogs. J Vet Emerg Crit Care 14(3):203-212, 2004
  • Chubb LS, Andersen ME, Broccardo CJ, Legare ME, Billings RE, Dean CE, Hanneman WH. Regional induction of CYP1A1 in rat liver following treatment with mixtures of PCB 126 and PCB 153. Toxicol Pathol 32:(4)467-473, 2004.
  • Legare ME, Hanneman WH. Genetic, biochemical and anatomic characterization of neurological mutant 3, a new mouse model for Parkinson's disease. Genetic Molecular Res 2(3):288-294, 2003
  • VonMaier MS, Legare ME, Hanneman WH. How does dioxin affect gene expression in nerve cells: identifying novel dioxin-inducible gene targets in neuronal cells. Proc Soc Tox, 2003
  • Hanneman WH, Andersen M, Legare ME, French T, McMUllin T, Broccardo C, Billings R. The exposure dose-response paradigm as it relates to toxicogenomics. In: In Vitro Neurotoxicology: Principles and Challenges. Mannfred Hollinger, (ed). Human Press Inc, 2003
  • Legare ME, Mason GL. Microcystin and hepatotoxicity. AFIP Conference 2003.
  • Nystuen A, Legare ME, Shultz LD, Frankel WN. A null mutation in inositol polyphosphatase type I causes selective neuronal loss in weeble mutant mice. Neuron 32 (2):203-12, 2001.