D. N. Rao Veeramachaneni, BVSc, MScVet, PhDProfessor Office: W146 ARBL Building, Foothills Campus Member Education Link to a PubMed listing of Dr. Veeramachaneni's
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Teaching Activities
I teach in the areas of physiology, pathophysiology, and toxicology in several courses at undergraduate and graduate levels and coordinate two courses in the Undergraduate Major in Biomedical Sciences (BMS360-Fundamentals of Physiology and cap-stone BMS460-Essentials of Pathophysiology). I also provide hands-on instruction in the areas of histology, histopathology, and immunocytochemistry at light and electron microscopic levels.
Research Interests -- Andrology and Reproductive Toxicology
I have been studying the male reproductive system in a variety of animal species with the aim of broadly integrating functional aspects of different components of the system in health and disease. There has been a concern about declining seminal quality and reproductive health in men worldwide. In an attempt to understand if this problem is really idiopathic, as male infertility often is labeled, or a consequence of exposure to environmental pollutants, my current research is focused on investigating long-term sequelae of exposure in utero and/or during infancy to ubiquitous chemical contaminants. Of particular interest is pathogenesis of carcinoma in situ in the testis.
For additional information on current projects, consult the page on Reproductive Toxicology.
Service Activities
Applying this rather broad line of scientific pursuit, I also have been providing clinical and research support services. These services include evaluation of male reproductive tissues and semen for morphology and ultrastructural cytopathology enabling diagnosis of disease conditions and/or assessment of potential fertility. A wide spectrum of species including domesticated (cattle, horses, dogs, and cats) and wild animals (cheetah, deer and eland) have been referred from around the world. In some cases, knowledge acquired from laboratory research enabled association of possible etiological/environmental factors to the condition manifested.
For additional information on services offered for sperm morphology and use of semen as biopsy material, consult the page on Sperm Morphology Services.
Representative Publications
Veeramachaneni DNR. 2007. Impact of environmental pollutants on the male: Effects on germ cell differentiation. Anim Reprod Sci. In Press (Understanding and Exploiting Spermatozoa - A Festschrift for Rupert P. Amann).
Veeramachaneni DNR, Palmer JS, and Klinefelter GR. 2007. Chronic exposure to low levels of dibromoacetic acid, a water disinfection by-product, adversely affects reproductive function in male rabbits. J Androl 28:565-577.
Veeramachaneni DNR, Palmer JS, Amann RP, and Pau K-YF. 2007. Sequelae in male rabbits following developmental exposure to p,p'-DDT or a mixture of p,p'-DDT and vinclozolin: cryptorchidism, germ cell atypia, and sexual dysfunction. Reprod Toxicol 23:353-365.
Amann RP and Veeramachaneni DNR. 2007. Cryptorchidism in common eutherian mammals. Reproduction:133:541-561.
Meyer KJ, Reif JS, Veeramachaneni DNR, Luben TJ, Mosley BS, and Nuckols
JR. 2006. Agricultural pesticide use and hypospadias in Eastern Arkansas.
Environ Health Perspect 114:1589-1595.
Bisenius ES, Veeramachaneni DNR, Sammonds GE, Tobet S. 2006. Sex differences and the development of the rabbit brain: Effects of vinclozolin. Biol Reprod:75:469-476.
Veeramachaneni DNR, Palmer JS, Amann RP, Kane CM, Higuchi TT, Pau K-YF. 2006. Disruption of sexual function, FSH secretion, and spermiogenesis in rabbits following developmental exposure to vinclozolin, a fungicide. Reproduction 131:805-816.
Veeramachaneni DNR, Amann RP, Jacobson JP. 2006. Testis-antler dysgenesis in Sitka Black-tailed deer on Kodiak Island, Alaska: Sequela of environmental endocrine disruption? Environ Health Perspect 114 (Suppl 1):51-59.
Veeramachaneni DNR. 2006. Germ cell atypia in undescended testes hinges on the aetiology of cryptorchidism but not the abdominal location per se. Int J Androl 29:235-240.
Weber NM, Sawyer HR, Legare ME, Veeramachaneni DNR. 2006. Sub-chronic exposure to dibromoacetic acid, a water disinfection by-product, does not affect gametogenic potential in mice. Toxicol Sci 89:325-330.
Lee SK, Owens GA, Veeramachaneni DNR. 2005. Exposure to low concentrations of di-n-butyl phthalate during embryogenesis reduces the survivability and impairs development of Xenopus laevis frogs. J Toxicol Environ Health Part A 68:763-772.
Lee SK, Veeramachaneni DNR. 2005. Sub-chronic exposures to low concentrations of di-n-butyl phthalate disrupts spermatogenesis in Xenopus laevis frogs. Toxicol Sci 84:394-407.
Weber NM, Higuchi TT, Tessari JD, Veeramachaneni DNR. 2004. Evaluation of effects of water disinfection by-products, bromochloroacetic and dibromoacetic acids, on frog embryogenesis. J Toxicol Environ Health A 67:929-939.
Bodensteiner KJ, Sawyer HR, Moeller CL, Kane CM, Pau K-YF, Klinefelter GR, Veeramachaneni DNR. 2004. Chronic exposure to dibromoacetic acid, a water disinfection by-product, diminishes primordial follicle populations in the rabbit. Toxicol Sci 80:83-91.
Higuchi TT, Palmer JS, Gray LE Jr, Veeramachaneni DNR. 2003. Effects of dibutyl phthalate in male rabbits following in utero, adolescent, or post-pubertal exposure. Toxicol Sci 72:301-313.
Lange IG, Daxenberger A, Meyer HHD, Rajpert-De Meyts E, Skakkebaek NE, Veeramachaneni DNR. 2002. Quantitative assessment of fetal exposure to trenbolone acetate, zeranol, and melengestrol acetate following maternal dosing in rabbits. Xenobiotica 32:641-651.
Veeramachaneni DNR, Palmer JS, Amann RP. 2001. Long-term effects on male reproduction of early exposure to common chemical contaminants in drinking water. Human Reprod 16:979-987.
Gray LE Jr, Ostby J, Furr J, Wolf CJ, Lambright C, Parks L, Veeramachaneni DNR, Wilson V, Price M, Hotchkiss A, Orlando E, Guillette L. 2001. Effects of environmental antiandrogens in experimental animals. Human Reprod Update 7:248-264.
Roberts D, Veeramachaneni DNR, Schlaff WD, Awoniyi CA. 2000. Effects of chronic dietary exposure to genistein, a phytoestrogen, during various stages of development on reproductive hormones and spermatogenesis in rats. Endocrine 13:281-286.
Gray LE Jr, Ostby J, Furr J, Price M, Veeramachaneni DNR, Parks L. 2000. Perinatal exposure to the phthalates DEHP, BBP and DINP, but not DEP, DMP or DOTP alters sexual differentiation of the male rat. Tox Sci 58:350-365.
Veeramachaneni DNR. 2000. Deteriorating trends in male reproduction: Idiopathic or Environmental? Anim Reprod Sci 60-61:121-130. (Plenary lecture, XIV International Congress on Animal Reproduction, Stockholm)
