Melinda A. Frye, DVM, PhD, DACVIM Assistant Professor Department of Biomedical Sciences Colorado State University Fort Collins, CO 80523 Phone: 970-491-4280 Fax: 970-491-7569 Email: Melinda.Frye@colostate.edu Education PhD, Colorado State University MS, Colorado State University DVM, Colorado State University BSN, Linfield College Diplomate American College of Veterinary Internal Medicine

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Teaching Interests

Subjects:

• Physiology and pathophysiology, primarily cardiovascular and pulmonary
• Comparative anatomy and physiology
• Application of physiologic principles to human and animal medicine
• Large animal clinical cardiology and internal medicine

Methods:

• Incorporation of tissues, live demonstrations, and advanced audiovisual technology into the learning environment
• Web-based resources and learning
• Review of current literature
• Provision of learning opportunities requiring critical thinking and practical application of principles learned

Research Interests

1. Under conditions of dietary fatty acid manipulation in the rat:

• Development of lipidomic strategies to study changes in cardiomyocyte and coronary microvascualar endothelial cell eicosanoid synthesis and oxidation
• Measurement of associated functional changes in vivo using echocardiography

2. Optimization of the dietary obese rodent model to study the role of the visceral adipose in obesity cardiomyopathy

3. Investigation of lipid-mediated cardiac and endothelial dysfunction in veterinary patients

Representative Publications

Frye MA, Johnson JS, Traub-Dargatz J, Savage CJ, Fettman MJ, Gould DH. 2001. Putative uremic encephalopathy in horses: 5 cases (1978-1998). J Am Vet Med Assoc 218:560-566.

Frye MA, Selders CG, Mama KR, Wagner AE, Bright JM. 2002. Use of biphasic electrical cardioversion for treatment of idiopathic atrial fibrillation in two horses. J Am Vet Med Assoc 220:1039-1045.

Frye MA, Bright JM, Dargatz DA, Fettman MJ, Frisbie DD, Baker DC, Traub-Dargatz JL. 2003. A comparison of dobutamine infusion to exercise as a cardiac stress test in healthy horses. J Vet Internal Med 17:58-64.

Frye MA. 2006. Pathophysiology, diagnosis, and management of urinary tract infection in horses. Vet Clin Equine 22:497-517.

Lawler JB, Frye MA, Bera MM, Ehrhart EJ, Bright JM. 2008. Third-degree atrioventricular block in a horse secondary to rattlesnake envenomation. J Vet Intern Med 22:486-90.

Frye M, McMurtry I, Orton EC, Fagan K. 2009. Use of fat-fed rats to study the metabolic and vascular sequelae of obesity and beta-adrenergic antagonism. Comp Med 59:1-7.

Gentile C, Frye M, Pagliassotti M. 2010. Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease. Antioxid Redox Signal 15:505-521.

Gentile CL, Frye MA, Pagliassotti MJ. 2010. Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. Biofactors 37:8-16.

Jeckel KM, Miller KE, Chicco AJ, Chapman PL, Mulligan CM, Falcone PH, Miller ML, Pagliassotti MJ, Frye MA. 2011. The role of dietary fatty acids in predicting myocardial structure in fat-fed rats. Lipids Health Dis 10:92.

Frye MA, Cook V. Cardiovascular system. In: Equine Emergency Medicine and Critical Care, Southwood LL and Wilkins PA (eds). Manson Publishing, Middlesex. In press.