Course Description: Pharmacologic principles, absorption, distribution, metabolism, excretion, side effects, and actions of drugs.
Course Objectives: This course will teach the general principles of pharmacology, so that the student will understand the theoretical considerations that are involved in selecting and administering any drug. To that end, the emphasis will be on developing a conceptual understanding of certain prototype drugs, which are taught because of their medical or societal importance, as well as heuristic value. Although some review will be provided, the student is expected to be able to integrate his/her prior knowledge of mathematics, chemistry, physiology and biology for the purpose of the course.
Prerequisites: BMS 300, BMS 310 or BZ 310
Format: 3 credits - 3 hours of lecture per week
Semesters Offered: Spring
Coordinator: D.N. Ishii
Text: Human Pharmacology, Molecular to Clinical, 3rd ed., (1998), Brody, Larner and Minneman
Course Outline:
| Week 1: | Introduction, bioavailability, routes of administration, absorption | |
| Week 2: | Oral absorption, ion trapping, distribution, elimination | |
| Week 3: | Pharmacokinetics I, pharmacodynamics I | |
| Week 4: | Pharmacodynamics II, insulin and oral hypoglycemic agents | |
| Week 5: | Insulin receptors and therapeutics, glucocorticoids, mineralocorticoids | |
| Week 6: | Contraceptives, morphine and strong analgesics | |
| Week 7: | Amphetamines and cocaine, neuromuscular blocking agents, tranquilizers and anti-seizure drugs | |
| Week 8: | Anti-histamines and nonsteroidal anti-inflammatory drugs, aspirin and weak analgesics | |
| Week 9: | Autonomic nervous system review, autonomic nervous system drugs, arterial blood pressure regulation | |
| Week 10: | Antihypertensive drugs, cardiac electrophysiology | |
| Week 11: | Modulation of cardiac contraction, vasodilators, diuretics | |
| Week 12: | Congestive heart failure, Rx, Anti-cancer agents I | |
| Week 13: | Anti-cancer agents II, bacterial cell wall inhibitors, bacterial protein synthesis inhibitors | |
| Week 14: | Bacterial folate antagonists, anti-fungal agents, anti-viral agents | |
| Week 15: | Antipsychotic agents, Anti-AIDS advances, biotechnology and new drugs |
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